Member Info for Lionel1

Https://x.com/angie_velinor/status/1838931978227249457

Genedrive recruited 5 ppl in last 2 months .

https://www.linkedin.com/posts/genedrive-plc_gdr-poct-pharmacogenetics-activity-7250540220289282048-CKkN?utm_source=share&utm_medium=member_ios

Pharmacogenomics will be implemented across NHS sooner or later.

https://pure-oai.bham.ac.uk/ws/files/201126436/bcp.15820.pdf

Look at the potential market just in UK

https://www.stroke.org.uk/stroke/statistics

Https://academic.oup.com/ehjcvp/article-abstract/10/6/481/7739585?redirectedFrom=PDF

CYP2C19

Cytochrome P450 2C19 (CYP2C19) is a hepatic enzyme responsible for the metabolism of mavacamten as well as many other commonly used medications.4 CYP2C19 is encoded by the CYP2C19 gene. Common loss of function variants in the CYP2C19 gene predict a decreased metabolism phenotype. Based on clinical trial evidence, the UK regulator, the Medicines and Healthcare products Regulatory Agency and the European Union regulator, The European Medicines Agency have advised that all patients should undergo CYP2C19 genotyping before commencing mavacamten therapy.3 This is because patients with a CYP2C19 poor metabolizer phenotype (which can be predicted from the presence of two CYP2C19 loss of function variants—one from each parent) have increased mavacamten exposure leading to increased risk of systolic dysfunction, a type A adverse drug reaction (otherwise known as too much of a good thing). Therefore, regulators have recommended both a lower a starting dose and a lower maximum dose of mavacamten for genetically predicted poor metabolizers.3 This testing is now available, and the first prescriptions have been issued in the UK and in the EU.

Anybody has full access to this document ?

GDR always surges days leading up to a Good RNS , I wonder what it is ? I think it is some thing to do with FDA ..

Https://www.linkedin.com/posts/nihr-research_genedrive-kit-for-babies-activity-7247976289989455873-X58K?utm_source=share&utm_medium=member_ios

@Jimi , The original contract date was 2021 , it was discontinued at that time but it was reinitiated and contract Awarded on 3rd Sep . But the only thing we are not sure about is the Unnamed contractor .

Https://bidstats.uk/tenders/2024/W36/829947990

For the believers.

https://youtu.be/WdVGXFCiFh8?si=UrN-ObWZa-m8Jype

STF Joe , you have no idea what you talking about, WGS is different from urgent care , WGS results takes nearly a month..

Genedrive POC

https://youtu.be/CmFtVHflLmc?si=TEdl5SrAOxUwPS9x

And also this .

https://www.nice.org.uk/guidance/hte6/resources/evidencegeneration-plan-for-genedrive-mtrnr1-id-kit-for-detecting-a-genetic-variant-to-guide-antibiotic-use-and-prevent-hearing-loss-in-babies-13127890285/chapter/3

Evidence generation period is 3 years after than NICE will take decision on NHS adaptation, until that it is individual trusts decision, this will be fully implemented across NHS by 2026 . Good night

@JH, Read the last paragraph.

https://www.nice.org.uk/guidance/hte6/resources/evidencegeneration-plan-for-genedrive-mtrnr1-id-kit-for-detecting-a-genetic-variant-to-guide-antibiotic-use-and-prevent-hearing-loss-in-babies-13127890285/chapter/1

Lol pump and dump crew just boarded the train :-)

All stars aligning for GDR ..

https://pathologyinpractice.com/story/45973/darzi-review-ibms-and-bivda-respond

More info .

https://ojeu.com/ojdblnk/view-notice.php?id=3897165

Genedrive ???

https://bidstats.uk/tenders/2024/W36/829947990

Good one Stephen.

Time for GinoDrive

Register yourself if you are interested.

https://us02web.zoom.us/webinar/register/WN_z6y8IK8fSTWzXnKuM4cz_Q#/registration