RE: Was hoping for a more comprehensive RNS today11 Sep 2023 13:27
There has been no RNS. Last week a very late REACH was released to cover that the CBR patent had been unsealed, it was the discovery of the patent details that triggered the 30% rise. No Reach/RNS was required as the patent unsealing was a known and anticipated event that is outside control of Hemognenyx.
You can find details here:
https://patentscope.wipo.int/search/en/detail.jsf;jsessionid=217A34C3B21FD7466B4FC114D3D34894.wapp1nB?docId=WO2023168292&_gid=202336
Read it for yourself and make up your own mind... I will share with you a short extract:
6.3
Example 3: Analysis of CBR-induced phagocytosis of SARS-CoV-2 variants. [00334] The experiment described in Example 2 was repeated to test the ability of CBR- transduced cells to recognize and phagocytose spike proteins from two different SARS-CoV-2 variants (UK alpha variant B.1.1.7 & Delta variant B.1.617.2). Specifically, Thp1 cells were transduced with lentivirus carrying F4-AC construct under EF1a promoter, the cells were stained with biotinylated SARS-CoV-2 Spike protein from either the UK alpha variant, B.1.1.7 (ACROBiosystems, Delaware Technology Park, DE) or the Delta variant, B.1.617.2 (SinoBiological, Wayne, PA), followed by PE-streptavidin (BioLegend, San Diego, CA), and positive cells were sorted using Melody sorter (BD, Franklin Lakes, NJ). Streptavidin-coated 5.06 um beads (Spherotech, Lake Forest, IL) were sterilized using 70% isopropanol and labeled with 10uM pHrodo red dye (Thermo Fisher, Waltham, MA) according to manufacturer instructions. Washed beads were then incubated with biotinylated Spike protein at a ratio of 0.025 nmole biotinylated Spike protein per 0.5mg beads. Beads were incubated overnight with cells at a ratio of 1:5 (cells: beads).
[00335] As shown in FIG. 4A-4B, both wild-type Spike-coated beads and B1.1.7 Spike-coated beads were phagocytosed and only by Thp1 that were transduced with the mannose receptor-based CBR construct containing ACE2 bait on the surface. Non-coated beads were not phagocytosed and untransduced (UTD) cells did not phagocytose any beads.
[00336] Similarly, both wild-type Spike-coated beads and B.1.617.2 Spike-coated beads were phagocytosed and only by Thp1 that were transduced with the mannose receptor-based CBR construct containing ACE2 bait on the surface (FIG. 5A-5B). Non-coated beads were not phagocytosed and untransduced (UTD) cells did not phagocytose any beads.
[00337]
The results of this test demonstrate that CBRs can bind to viral proteins from multiple variant strains and induce phagocytosis in a binding-specific manner.
I think you will agree the level of detail is worthy of the 30% rise and much more besides. Hard for people to argue CBR is fake when Vlad is providing the full cook book with ingredients for others to go and try themselves.
Sign In
Follow the stocks
