Member Info for Fruitsnveg

"Most of us understand that the cost of this will be huge in terms of surrendered equity, however it happens."

Most of us should understand that there's no such thing as a free lunch. As long as any hypothetical dealis *mutually beneficial* (i.e. for Us it results in an approved drug that will meet clinical need and thus generate income, increase valuation, give us our well earned ROI, etc), then we should consider that a fair exchange. Quid pro quo. NO small biotech goes it alone. Sooner or later they all need scaffolding to get a drug(s) to market. I remain optimistic and openminded. The fat lady will soon sing.

"I have no faith in this board and will be selling if the opportunity arises."

I see you are expressing the same feelings today as the day that you first "invested" here.... which is interesting, MrI'm2busytrollingtogototheAGM...

Non-dilutive funding options exist, so in the absence of evidence to the contrary, they can't be ruled out;

BARDA funds companies that develop medical countermeasures that address public health and the consequences of pandemic flu and emerging diseases like SARS-CoV-2 and COVID-19.

There are also partnering opportunities; we know that the company have actively attended such sessions previously. Many partnering arrangements and collaborations are mutually beneficial.

Another funding source from BARDA, in collaboration with NIAID, is Project NextGen. This initiative coordinates with the government and private sectors to advance new vaccines and therapeutics through R&D, clinical trials, and then get FDA authorisation.

There's also public-private partnerships, government research and industry grant funding from numerous sources.

Non-dilutive funding can't be ruled out unless the company say it is.

"Best case scenario from here is a deal similar to one struck with AZ back in 2015". I wouldn't be so quick to mark your cards down. There's a lot we don't know. Worth remembering AZ and JJ are not the only BPs in Pandemic Prep Town. Hopefully the recent CFO will have been looking at non-dilutive routes to elongating our cash runway. He should have been doing that since Day 1 .

For the avoidance of any doubt, SSH is but one of 3 co-founder's.

" since they couldn't force a SPAC exit for themselves when Marsden et al spurned the best efforts of Morgan Stanley, Rick Bright, Ray Jordan etc."

What nonsense is this, pray tell? Morgan Stanley??? Do explain Spacemen because these claims seem very fantastical. Have you any actual evidence of this?

And there we have it; " further study for the optimal antiviral treatment in MERS is warranted." Which matches Synairgen's development path for SNG001.

The WHO has stated that mild cases of MERS-CoV "may be missed by existing surveillance systems" so continued (yet as yet unidentified) infections could be spreading and I guess if we are unlucky, spread far away from the site of initial infection by, for example, air travel. The horse has already bolted when 2 people caught it in a hospital from case zero with no camels present. But hopefully their efforts now will mean they won't find more cases.

However, that does not diminish future risk. For MERS no vaccine or specific treatment is currently available, although several MERS-CoV-specific vaccines and therapeutics are in development. I expect SNG001 may be a possible candidate drug, having show efficacy against MERS in the lab. Whether or not the Saudi infections are successfully quelled, the fact that H2H transmission is happening must underline the growing need for BP's and governments to crack on and ready their pandemic toolkits. It is clear from this and H5N1 spread in the US that those toolkits need further development, now, not when the next local outbreak occurs. These viruses are unpredictable and they can travel fast in our well connected world.

"Contact to index case" means Human-to-Human transmission. I'm sure you understand camels were not involved when one patient passed to 2 others in a healthcare facility. Whether camels were involved as a first step will pale into insignificance if more human-to-human cases are contact traced.

And no, it is not " reasonable to assume that if there was going to be a wider outbreak it would have happened by now" According to the NIH , the extent of asymptomatic MERS-CoV cases is about 10% from different studies.

Finally in case it slipped your mind, the company we are invested in, Synairgen, have already conducted pre-clinical research of SNG001 showing the inhibition of Middle East Respiratory Syndrome-Coronavirus in cell-based assays.

Https://www.telegraph.co.uk/global-health/science-and-disease/mers-outbreak-saudi-arabia-middle-east-respiratory-syndrome/

“The health analytic firm Airfinty, which monitors disease outbreaks globally, said there was a “high threat” for the city Riyadh.

“Mers-CoV [is] still around and still a threat,” Prof Peter Horby, director of the Pandemic Sciences Institute at the University of Oxford said on X. “[Saudi Arabia] has great experience of detecting and controlling health-care associated MERS transmission – other places are less aware and less prepared. ”

Https://twitter.com/RickABright/status/1788709392755372035

"and more importantly shows incredible data to back up its patient identification techniques".

work for AZ after all. Like Sakura.

I would lower expectations that the company will share commercially sensitive information like this with just anyone. You could work for a competitor after all.

"never materialised". I'd qualify that with a hefty "Yet".

My position has not moved DocDan. One outcome does not limit the other from being possible. I would assume that something is going on. And that they cannot update us yet.

My guess is it's less a case of "Synairgen have essentially decided to shut up shop in terms of any communication at all to shareholders", and more a case of the company being bound by NDA/s. The degree of silence is unprecedented and the hiring in November was silent, and coordinated. For good reason I hope.

Small observation but think you'll find the majority are actually trolls pretending to be "individuals expressing concern are frustrated investors caught up in the unfortunate Sprinter outcome". Not really the same thing.

Not sure if the article is visible to all (?) but the summary at end states that "“We’re not going to be ready,” Katrine Wallace, epidemiologist at the University of Illinois, said. “We’re not even dealing with what’s right in front of us.”

Posting IN THE CONTEXT of current H5N1 threat in the US. We know that "Pre-clinical research conducted by Synairgen of IFN-β (at concentrations readily achievable following inhaled delivery of SNG001) shows the inhibition of a broad range of viruses in cell-based assays including: viruses which cause seasonal cold (e.g., RSV, Rhinovirus) and flu infections highly pathogenic viruses such as H5N1 ‘bird flu’ and Middle East Respiratory Syndrome-Coronavirus (MERS-CoV)".

Https://www.bloomberg.com/news/articles/2024-05-08/us-bird-flu-risk-1-human-case-reported-more-likely-to-follow?srnd=homepage-americas&embedded-checkout=true

MrCosts2much.

Then again, he may be travelling in from his trading desk at Citadel, 120 London Wall London. ..

Fantasy Heights, 1 Joke Street, Liarsville H0H0 XXX.

Did I miss anything?

You're the joke.