Member Info for euclid55

3.2. Aptamers Used in Biosensors
The ease of which different aptamer structures can be generated together with their ability to bind specific targets by forming stable tertiary structures has led to widespread applications of aptamers in biosensors

Aptamers used in biosensors. Aptamer-based biosensors are used to detect disease biomarkers, monitor environmental contaminants, or to ensure food safety.

Aptamers can be further enhanced by different nanomaterials or biomaterials. The signal of detection in the most of the recently developed aptamer-based biosensors is based on electric or optic/fluorescent signal.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429292/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429292/figure/molecules-24-00941-f003/

Something CEO negotiated on an off market transaction

Coldspy, T|B shouldn't be giving you or any s/holder any form of indication his intentions what he plans to do with his shares. Be it buy/sell.

Anyway, good news today on him buying up the bal o/s of A Norris's shares

RNs out - TB has just bought A Norris's 3.1% holding or 972k shs.....a very good move imo

https://www.investegate.co.uk/braveheart-inv-group--brh-/rns/director-pdmr-shareholding/202006051244371451P/

Coldspy, do you really believe he said that to a small s/holder??

He is going to say that anyway - he isn't exactly going to say my intention is to sell another 1 or 2 m shares, is he

Hi LB28

Just sent you pm

Discovery of Aptamers Targeting Receptor-Binding Domain of the SARS-CoV-2 Spike Glycoprotein

Due to the chemical nature ofnucleic acid, aptamers can be chemically synthesized, precisely modified, high thermallystable, and possess little batch-to-batch variation.

These traits make for convenient transportation,storage, and standardization. Additionally,aptamers can be combined with othertechnologies to expand their performance and applications

https://chemrxiv.org/articles/Discovery_of_Aptamers_Targeting_Receptor-Binding_Domain_of_the_SARS-CoV-2_Spike_Glycoprotein/12053535/1?file=22151205
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The required affinity macromolecule (an aptamer which binds to the Spike glycoprotein on the surface of the virus) is now being synthesised for Paraytec by a UK university-based laboratory and will be supplied imminently.

https://www.investegate.co.uk/braveheart-inv-group--brh-/rns/further-re-paraytec-limited/202006010700085021O/

replied back

drop us a pm please

Brh will receive all of the funds on conversion of the warrants at 40p - assuming all s/holders covert their warrants

Bladermann, they don't sell the wrts at 40p - they have the right to the warrants & pay 40p for them - so they have to sell them above 40p to profit from them - if they elect to convert they get to buy the wrts at 40p then sell them onfor as many shares as they are entitled to from the warrants

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A stock warrant is a financial contract between a company and investors that gives the investor the option to purchase the company's stock at a specific price and by a specific date. A stock warrant allows the holder to receive newly issued stock from the same company that provided the warrant. While the warrant expires after a certain date, the investor is still allowed to make the stock warrant purchase (via common stocks) at a later date if he or she chooses.

Structurally, stock warrants are used to attract buyers to a company's stock, potentially enabling the recipient to buy the stock down the road at the warrant's "strike price" (the agreed-upon price) at a price lower than the stock may be trading.

https://www.thestreet.com/investing/what-are-stock-warrants-15020045

Bladerman, that will be more concerning if those 2 large s/holders are reducing their holding - why would they in light of the direction the co is going in?

AG Simpson and W Rehman?

Yes, they can appoint another aptamer producing organisation - their UVI Imaging system is the main unique tool in all this work.

TorreG,

They will still have to test the device once they have installed all the details they require

can someone please add my below note onto twitter - so it educates people on the technical side of things

Many investors think that not carrying forward with the Aptamer Group is really negative - but it isn't

Technically with Paraytec's unque Uvi imaging system, it can source, isolate and bind the correct aptamers to the spike protein of the covid19

Don't forget that Paraytec Ltd, do not have to be a partner with The Aptamer Group Because they can simply buy Aptamers products only from another aptamer producing company.

So not partnering with The Aptamer Group, isn't muchof a loss to them - plus Paraytec Ltd own the IP rights to the device being developed.

He started that scooter company in April 2019 - over 1 year ago

https://www.somersetlive.co.uk/news/business/glastonbury-man-hopes-change-law-2773522

Former Hargreaves Lansdown director, Adam Norris has ploughed £10million of his own money into a new electric scooter venture

Bladderman,
Adam Norris has already invested £10m into his new electric scooter company so doubt very much he needed to raise another £1m odd on the sale of his 16% holding in BRH

what's the name of his new start up company please?

Professor Carl Smyth

Brief career history

2002 – present: Professor of Cell Biology, Department of Biomedical Science, University of Sheffield
2004 – 2006: Head of Department, Department of Biomedical Science, University of Sheffield
1992 – 2002: Principal Investigator at MRC Protein Phosphorylation Unit, University of Dundee
1989 – 1992: American Cancer Society Senior Research Fellow, University of California, San Diego
1985 – 1989: British Diabetic Association postdoctoral research assistant at MRC Protein Phosphorylation Group at University of Dundee
1981 – 1985: PhD Department of Biochemistry, Trinity College, University of Dublin

https://www.sheffield.ac.uk/bms/research/csmythe#tab00