keeping on topic12 Sep 2022 14:06
I've sometimes wondered whether AVA6k is more 'torpedo', or 'sea mine', bobbing around, waiting to bump into some FAP and cleave ('go off') and kill everything around, or strike the FAP and penetrate, focussing on the cancer cells (torpedo). But since tumours grow their own veins, get a blood supply, and grow outwards taking the path of least resistance, the blood supply should deliver the dox straight to the interior of the tumour rather than the outside of it, so 'torpedo' or 'mine', it doesn't really matter. Inside the tumour, everything is a legitimate target.
And since cleaving is probably a slightly drawn out process rathe than instantaneous, what liberated Dox that does escape is probably diluted (more than Dox in regular chemo) as it leaves the site to be broken down.
I know that's absolutely the layperson's view but might it be what could happen?