Member Info for Cymru229

Our test at this stage is a blood draw sent to labs for testing. Remember BioTechne discussions last year, they have also partnered with Ciz and have a machine that can test at scale. That was a large missing link for us to commercialise. They needed a machine that could do the lab tests at scale and got one via BioTechne (who are multi billion pound organisation) have a read through previous RNS and Interviews. Manufacturing of a lateral flow type test is a future ambition.

Read the next bit of the RNS they are submitting Q2 and the last sentence of this section says the accreditation should be immediate unless any clarifications are raised. So glass half full, they could be selling the test as early as two or three weeks time or glass half empty just over 3 months time glass fully empty there are clarifications then who knows....but all sounds very positive based on that Omni link.

CLIA Accreditation

BIO's strategy is to achieve CLIA accreditation and market launch of the Company's CIZ1B biomarker test with its clinical diagnostics partner Omni in the shortest time possible, thus enabling a roll out campaign across North America. The CLIA accreditation process is necessarily detailed requiring rigorous validation following strict operating procedures. The results generated provide information on analytical accuracy and precision, that together with Omni's own quality assurance processes, provide the basis for submitting the accreditation application. Key personnel from the Company have been working alongside Omni's team in the laboratory in Texas, who expect to complete the testing programme shortly. On submission, accreditation is usually immediate unless any clarification is sought

I could be wrong though but I have enough in with CIZ UK so not looked at the US investment in detail

I was aware of that but that round of funding is closed I believe so no further access to buying in the US CIZ until they have another round of investment or list

Nope the US CIZ are a private company and not a listed business just CIZ UK who are main market listed.

After buying in the open market and with the CLN their holding is 13.84% which is a decent chunk of the business

Agree he should bring more experience to the board and he definitely needs the share price to be double current the price so he can get paid via his options. Otherwise he is working for free...so it will be very much in his interestes to drive the share price up with positive newsflow from Ciz.

Great news, deal finally concluded and the next few months strategy remains in place. Accreditation this year, launch of product in April and no further dilution for shareholders expected. Income to Ciz from the off and lots of other opportunities being chased in the USA.

This should be the start of the ‘Inflection point’ AS has been communicating with a positive step for our product both to make a positive impact on people with lung cancer and hopefully that upward climb in share price for us all

Seems to me that they have the original MOU details in place but need a little more time include some additional strategic investment which should be positive for us 'to enable BIO to complete on additional strategic investment that has been proposed. As Cizzle will be granted a 10% stake in BIO, for no cash consideration on closing, the Cizzle Directors believe that allowing for the extension will increase the value of the Company's stake in BIO and with access to greater funds BIO will be able to accelerate the deployment of its go to market strategy for the Company's CIZ1B biomarker test'

Disappointing that the legals have been extended but legals nearly always take longer than anticipated whether buying a house or selling your business or doing a deal. The positive is what is this additional strategic investment and what does that mean for us?

Another piece of the jigsaw falling into place. It definitley feels like there is excitement building as we head through the next few milestones to market.

We have the licencing agreement with Legals rubber stamped soon

We have the Bio Techne machines

We have the MAB's manufacturing agreement

We have the Cencer Centre Trials lined up

We have been given the expected timeline for FDA application and certification

and expected launch Q2 next year.

Exciting times for the public need for the test and for shareholders with tangible communication via the recent RNS's

As we continue to lead in lung cancer detection innovations.

A confident statement there must be excited and confident in the future of our test

Nice post TT gives balance yes there are still risks as with most companies in development, so not a done deal and things could still be challenging.

Don’t forget though we also own 10% of Bio in addition to the 10% royalties so that is beneficial to us too. We also hold the patents and science so more opportunities for other markets with equal or better deals for UK CIZ

This was never going to be a quick win but at least we have seen the first tangible roadmap to market

Well the share price is 20% higher than the 1.45 it was before the RNS so that is a little bit of interest? I am sure all investors are happier with that even though it is well below where we all want it to be.

When the MOU completes at the end of July (ish) then that should create further interest. There are three more milestone dates and an incoming anouncement that are now out in public beyond the MOU completion. Trials at the major Cancer Centre details will be announced when they can talk about it, Register with the FDA in Sept 24, gain certification in Nov 24 with insurer reimbursement code achievement and product launch next year. All these should generate more interest at each stage of the journey. The dates may slip a little depending on how they progress but provided we all get regularly updated along the way and each milestone gets chalked off then I am happy. This is, after all, what we asked for.

It is very positive in my opinion that this potentially game changing science is now finally in becoming a reality which will benefit shareholders, the Health Sector, initially over the pond, and ultimately all of us. If the share price does not react as we pass through each stage then that would be disapointing for shareholders and those who would benefit from the test therfore I remain optomistic. If things were not going to plan, why put out the timeline and why would there be a $2.4Million investment deal in legals currently?

I am nowhere near as reasearched as Neil on the share but until we are told that things have failed or not gone to plan then I remain positive about our future and I remain invested.

Yes, the concensus was that newsflow up until this point would have largely been regurgitating the science more so than about the actual product.

They noted it has been challenging and complex which has been frustrating but that some significant milestones have now been achieved, as communicated in the last RNS and within the interview.

This was one of the reasons for the the lack of communication, but now things are moving with partners aligned, the platform for the test sorted, the certification and product launch along with the Cancer Centre announcement.

This should now be the start of more regular and better news flow which will be more tangible for shareholders.

I shook hands and said hello with everyone who was there apart from the other shareholder who has been invested since the photonstar days. chatted to Justin, Dawn, Tim and Allan mostly.

Everyone voted for the resolutions in the room none angainst and after the formal meeting concluded I had some nice conversations.

Definitely seemed to be an air of positivity in the room following the recent ‘inflection point’ RNS and interview and thee securing of the $2.4million for a micro cap Biotech without a product in the market was unheard of.

So with the upcoming announcement of the Cancer Centre who selected CIZ when Allan is able to talk about it, the upcoming Trials and certification and product launch next year. All sounds good. I was asked about my interest in CIZ to which I gave my reasonings.

Glad I popped to the big smoke, happy to remain invested and looking forward to seeing what the next few months bring and meeting the CIZ board again.

Yes outside if CIZ board, Justin (Dawn’s Husband) and Allenby Capital there was also a couple of shareholders at the AGM.

The RNS gives a positive update on the MOU, with the minimum revenues that will bring regardless of any delay’s .

In addition we finally have some dates for FDA application and Certification they would not have provided them if they were not fairly confident of the product.

Patient study and target hospitals already identified.

Would we all like the product to be launched tomorrow, yes we would but having waited this long and having left the shire several years ago the journey is now at the foot of Mordor

Patience

That last sentence appears positive

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I have requested the corporate letter of representation from my broker and I plan on attending to vote in person. And if opportunity presents to discuss progress and ask questions I shall.

I just found a pound coin down the back of my sofa, think I better top up like everyone else is doing this morning before I miss out!