Member Info for crumbs

Shame they get banned.... a little rest is sometimes needed
keep punching C7 mate ... we still have email n that

Again:

'“We have identified some unique TCR
clones from CLTS(cancer longterm survivors)which recognise key
tumour targets. There are no previous
reports of T cells to these antigens, SO
THEY REPRESENT A SIGNIFICANT STEP
FORWARDS IN IMMUNOTHERAPY. They also
identify unique epitopes that can be
used for cancer vaccines.”

Lindy Durrant.....
hmmm....

'Our online symposium revealed groundbreaking results that are set to truly practice changing' March 27th

BTW.... what is Lindy doing with them?

'Research focus: Identification of novel
TCRs (T-cell receptors) and vaccine
epitopes for the treatment of cancer
patients from long term cancer survivors.
Lindy Durrant is Professor of Cancer
Immunotherapy at the University of
Nottingham. In 2019 she was awarded
the Waldenstrom prize for Cancer
Immunotherapy.
“We have identified some unique TCR
clones from CLTS which recognise key
tumour targets. There are no previous
reports of T cells to these antigens, so
they represent a significant step
forward in immunotherapy. They also
identify unique epitopes that can be
used for cancer vaccines.”

https://www.spectator.co.uk/article/are-we-ready-for-britain-s-looming-cancer-crisis-

'While daily updates on Covid case numbers and deaths give a picture of the grim toll of the pandemic, cancer just doesn’t work like that. A delayed diagnosis can turn a 80 per cent survival rate into 20 per cent and that is over a matter of months, not years. At Rutherford, my cancer centre network, we are now seeing far more patients than usual presenting with later-stage cancers. Lives have already been lost and the insidious, relentless nature of cancer will mean that will continue for some time.'

Come on SCIB1 combo and modi1 trials..... there are certainly going to be a large number of potential trial patients and a real need for such treatments.

Yeah, an 'we expect to have our seed potatoes in the ground by April the ......'

So I think we can say it is not the Notts vax that is coming as a booster in Autumn... we should be in trial then though!
We know this is a good place to be bringing a universal vax into trial... GOV.UK backing anything to stop more lockdowns... CEPI very much looking like a supporting fit....

It will, of course, all be down to data to how this all ends but the potential for this to go very well is very real.... so come on scancell no more timeline issues!

He'll be dicing with timing the last frosts for when to get his seedlings out :)

Yes it is also very novel however it is something Dr Dixon has spent many many years on and has patents to back it... again chance it and him could come in house as well as Putney to make scancell a notts bio pharma power house...

You have to think from doing the SKY and having a 'trial in weeks' the delivery is in order..... not sure it will be much of a challenge for cobra they seem well up to the task.... really we could do with being informed now though because the coming weeks are here now

In theory, we also have the delivery system (be good to get it fully confirmed)... it is to be fair my biggest concern however if Lindy green lights it then she has to be sure of it and it seems she is.... time for an RNS to let us know this trial is very much on its way

You always get inovio investors commenting on those CEPI tweets... not a chance fellas :) though they are already doing alright out of CEPI as it is!

Yes pretty much what I am saying
'Instead of making vaccines against each unique coronavirus or variant, what if we could provide protection through an all-in-one shot?'

BTW they retweet that quite a bit and it will no doubts to be due to this weeks expected big announcement of the proposals for universal vaxs

Still, a whack a mole tactic all be it three hammers at a time :)
Now if you did not have to worry too much about any of the variants as you had a vaxs that was more universal you could really open up

'Mr Zahawi also told the paper last week that ministers were expecting up to eight vaccines to be available by the autumn, and the Government was already talking to those three manufacturers about creating new versions of their jab that would be more effective against variants.

It includes one that could protect against three different Covid variants in a single jab.

Mr Zahawi said: "The Novavax technology allows us to have a bi-variant or tri-variant vaccine in the way you do with flu.

"So inside the actual vaccine itself, it can have more than one variant."

He added that Novavax would be available for the autumn vaccination drive.

Asked when the booster jabs would begin, Mr Zahawi said: "The most likely date will be September.

"Jonathan Van-Tam [the deputy chief medical officer] thinks that if we are going to see a requirement for a booster jab to protect the most vulnerable, [it] would be around September.”

The UK already has 60 million doses of the Novavax vaccine ordered.'

Aha the currant bun believes it could be the Novavax one
https://www.thesun.co.uk/news/14487077/matt-han****-brits-need-third-covid-jab-autumn-holiday/

The only reason I give it the slightest chance Coividity could be super fast-tracked is well... the absolute fear of having to go into a lockdown again just as this one is easing off.. a very real fear due to the 'variants' ... all very well re-engineering current vaxs for each appearing variant... but that is whack a mole.... we need something the blow up the burrow... again likelihood is Han**** is talking about an updated current vax a whack a mole one... but who knows!

Very speculative this... but CEPI and GOV.UK are on same page..and they want 100 day vaccines and are pushing a $1billion for R&D into next gen vaxs and are bringing forwards plans to develop vaccines to protect against variants...still Autumn seems rather soon but to cover 'variants' rather than a 'variant' would need something looking at more than just the spike

Still, all silence on the scancell front and RG has been locked in the potting shed without his tweeting smart phone:)

'Matt Han**** told ITV's This Morning that there could be a third vaccine used in the autumn in order to tackle coronavirus variants that become resistant against the current vaccines used in the UK. This Morning's co-host Phillip Schofield was left stunned by the admission.'
'Mr Han**** said: "We are also working on a new vaccine that we might have to roll out in the autumn to give people a third dose that will deal with this problem.'
'"We are working on that now."

Mr Schofield replied: "A third jab?"
The Health Secretary added: "There might be a third jab in the autumn, yes."
Mr Schofield responded: "So no international travel or holidays until the autumn?

"Those variants do exist out there as we know, we have been led to believe that the vaccines that we have are pretty effective against them.

"You say now that there are a couple that you are worried about, where are they?"

The Conservative MP said: "The two that we are most worried about started in South Africa and Brazil.
"They have spread a bit around the world."

The ITV host then asked: "What is the state of our vaccines against those two variants?"

Mr Han**** replied: "Well, we are not yet sure but we are doing the science and we are watching very closely'

So I dunno but would more think it would be a newer version of the Astra one? again I don't know and to protect against all variants you do really need a more 'universal vaccine' a Covidity.....

But once again shows us the UK is place to be making such a vax as it will get backed!

Yeah TF listed the 8 coming vaccines... however this is odd

'Mr Han**** said: "We are also working on a new vaccine that we might have to roll out in the autumn to give people a third dose that will deal with this problem.'

might have to roll out?.... some other term for fast track?... also the we are working on?.... again odd

That would happen on positive data and those variants threatening to bring us all back into or indeed into a lockdown -the Nottingham Vaccine that looks like it can beat the variants and help end the pandemic etc... We will get newsflow with potential CEPI/others action before that though and for sure a SKY report on first trial jabs :) ... hope we get to know the trial is going to indeed begin in the coming days!

We will hear news before a 'Boris announcement' I mean the trial needs to be got going and that will be news for one thing... and there could well be some CEPI action yet.... of course on super positive data I do think you would be hearing Boris and plenty more talking about the Nottingham Vaccine...