Member Info for crumbs

pharma not wanting to cure cancer is nonsense..... we are all at risk at dying of cancer including pharma CEO's their families workers scientists etc!.... not to name world leaders and mega-wealthy... Steve Jobs just for one...
Cancer is a multi-headed monster unique to each individual sufferer and you can think you have it beat only for it to grow a new head which is why it still has not been cured but the immune system is the way and getting it to be a chronic disease which means many cancer patients will need treatments for life etc and some high-risk people may get preventative vaccines etc so it's not quite it will ever be cured but it will get to a point where no one should ever suffer its worst effects .... and that is why immunotherapy is a revolution and still in its infancy and of course scancell still in with a great chance of playing a significant role...

Well a new Nigerian variant of concern seems to have arrived
https://www.kentlive.news/news/kent-news/new-nigerian-covid-strain-thats-5283063

That maybe RG could retweet seeing as this weather means he can't be putting out those seedlings yet!
Beijing has yet to approve any foreign vaccines for use in China, where the coronavirus emerged in late 2019.

https://twitter.com/wellcometrust/status/1380821103786958848

How do variants happen?

Cross mark And how can we prevent them?

https://abcnews.go.com/Health/wireStory/official-chinese-vaccines-effectiveness-low-77002863

Again this pandemic is not over due to 'herd immunity' its just settling in!

https://www.timesofisrael.com/real-world-israeli-data-shows-south-african-variant-better-at-bypassing-vaccine/

What happened was the thread vanished but then it came back as a covid variant could! Aghhh..

C7 I think most of us would agree on those points though on Covidity some think post ph1 ...me I think soon as!... Anyways so long as no more timeline slips and like I said before we are Q2 now so it is time to initiate those planned trials or once again we slip...and sp with it!

indeedy just by following up to date liks from your link we get
'CDC is closely monitoring these variants of concern (VOC). These variants have mutations in the virus genome that alter the characteristics and cause the virus to act differently in ways that are significant to public health (e.g., causes more severe disease, spreads more easily between humans, requires different treatments, changes the effectiveness of current vaccines).'
https://www.cdc.gov/coronavirus/2019-ncov/transmission/variant-cases.html

Yeah I prefer this SKY article :)

'Professor Lindy Durrant, an immunologist at the university and head of the spin-off company ScanCell, said the next generation of vaccines needs to be better prepared to tackle the virus as it "learns" to evade the immune system.

"What has happened was predictable," she exclusively told Sky News.

"We have the advantage of learning from the inadequacies of the first generation of vaccines to make the second generation better."

The three vaccines currently in use are all based on the genetic sequence of the spike protein, which the virus uses to latch onto human cells.

But mutations in the spike protein have emerged that have allowed new variants to spread rapidly in the UK, South Africa and Brazil. They may make existing vaccines less effective.

The Nottingham vaccine includes the spike protein, but also part of the "nucleocapsid" protein, a sheath that envelopes and protects the virus's genetic material. It mutates at a much slower rate.

"It doubles the chances you win over the virus," Prof Durrant said.

"The chances both will mutate at the same time is unlikely."
https://news.sky.com/story/covid-19-new-vaccine-in-development-has-insurance-against-virus-mutations-12217119

I don't think the Gov is taking for granted this pandemic is close to over.... insurance needed

Really!
' In the summer of 2020, this nursing home reported 25 positive cases of Covid-19. Several months later, from October to December, the same facility reported over 100 cases, with five testing positive for the second time. While only three of the five experienced moderate to severe symptoms of the first infection, all five did the second time around. One reinfected resident was hospitalized and succumbed to their illness.'

I don't think we can suppose what variants will emerge just because we want the best ones.... So we need insurance .... as for partners I agree infact on whole pipeline sooner or later and hopefully sooner scancell need to get with partners with the ability to advance products all the way..... it has been a failing here for since forever!

What would be the best insurance against having to go back into lockdown if a or many variants emerged that could reinfect previously infected and elude current vaccines... a more 'universal vaccine' Like I say to me pandemic is not over and Gov's are looking for insurance as the last thing any one wants is back into lockdown!

Covidity has legs.

That is great however that does not factor in emerging variants that can reinfect... a real thing

Like I say I hope it is the beginning of the end of the pandemic however I would not be too confident and as it says in that article
Han**** told LBC: "I was told by some scientists that we were going to have herd immunity in May and then in June and then after that.

"What I prefer to do is watch the data. We have set out the roadmap. The roadmap is really clear. It is our route back to normal."

He added: "I think we have taken the right course in plotting our way to freedom and doing it carefully because we want it to be irreversible."

'Covid-19 Reinfections Are Real And Serious—All The More Reason To Be Vaccinated'
https://www.forbes.com/sites/williamhaseltine/2021/03/10/covid-19-reinfections-are-real-and-serious-all-the-more-reason-to-be-vaccinated/?sh=49cca60c12e2

'While rare as of yet, reinfection cases seem to have more intense symptoms on average. A recent report from the Centers for Disease Control and Prevention (CDC) details reinfection in a Kentucky elderly facility. In the summer of 2020, this nursing home reported 25 positive cases of Covid-19. Several months later, from October to December, the same facility reported over 100 cases, with five testing positive for the second time. While only three of the five experienced moderate to severe symptoms of the first infection, all five did the second time around. One reinfected resident was hospitalized and succumbed to their illness.'

The pandemic ain't over the need for more effective vaccines is not over either... I agree to disagree... really hope you are right TBH and obviously one day there would be a natural herd immunity to CV19 but that could take generations....So Covidity still has its potential role to play

'OSLO, 10 March 2021 – Governments and global health bodies have expressed support for the Coalition for Epidemic Preparedness Innovations’ (CEPI) US$3.5 billion plan to dramatically reduce or even eliminate the future risk of pandemics and epidemics, potentially averting millions of deaths and trillions of dollars in economic damage.

At a launch event earlier today, CEPI set out an ambitious strategy to build a world that is better equipped to deal with pandemics and epidemics. CEPI is now calling on governments, global health organisations and strategic partners to back this critical investment in global health security over the next five years.

Supporters of the plan include the governments of Germany, Norway and Ethiopia; major philanthropies Wellcome and the Bill and Melinda Gates Foundation; the World Economic Forum; global health institutions such as WHO, Gavi and UNICEF; and industry partners.'

“
Reducing the risk of future pandemics and epidemics is a critical global issue that will benefit every single human on earth. The backing from governments and global health bodies for CEPI’s plan is testament to the importance of this issue, and the unique role that CEPI plays in this global effort. Our five-year plan is ambitious, yet achievable, and we look forward to working with everyone who has backed us so far to protect the world from the devastating impacts of pandemics and epidemics,
Dr. Richard Hatchett
Chief Executive Officer, CEPI'
https://cepi.net/news_cepi/global-leaders-support-cepi-plan-to-tackle-risk-of-future-pandemics/

Absolutely moon I guess if there is a sweet spot of being a deadly virus this one has found it ... highly transmissible and does not kill enough of its hosts fast enough to drive itself to extinction... it can afford to become more deadly than it already is and that seems to be happening in some variants how long it takes for our immunity to be able to handle it and it becomes less deadly who knows.... could be decades which of course is where vaccines come in and so far the vaccines are probably doing better than ever expected but the war has only just begun

Some variants indeed will be getting less deadly in probably in the long term those variants will dominate.. however that is not the case right now indeed more deadly variants are appearing...

'Results The mortality hazard ratio associated with infection with VOC-202012/1 compared with infection with previously circulating variants was 1.64 (95% confidence interval 1.32 to 2.04) in patients who tested positive for covid-19 in the community. In this comparatively low risk group, this represents an increase in deaths from 2.5 to 4.1 per 1000 detected cases.'
https://www.bmj.com/content/372/bmj.n579

There is going to be a C19 need to vaccinated against variants for the foreseeable and boosters against emerging variants Covidity still has a vital place and has full-on game-changer potential for scancell as a successful Covidity validates not just ImmunoBody but Avidimab and a whole new DNA vaccine delivery which in itself opens up and adds huge value ...

All living in the real pandemic world that.

Yeah, there are issues again ... I'll give it a bit more time H1 expectations and all... and we'll see
Scancell have taken on a huge amount we are now into TCR CAR T novel MaBs ADC bispecifics novel tech to improve all MaBs DNA vaccines a potential absolute game-changer in moditope with a whole new genre of its own siPTIMs ... and goodness knows what else.is coming! (anti-CAF based therapies).. all we need is one product to be successful but that there is where the block and its stumble fall

It does look at least on paper that the UK is a place to be ... So come on scancell let's change the world and me empty wallet too :)
https://www.gov.uk/government/publications/the-future-of-uk-clinical-research-delivery/saving-and-improving-lives-the-future-of-uk-clinical-research-delivery

C7 can you not begin a trial as in getting the clinics lined up CRO etc already despite COVID restrictions? surely if the product is being manufactured it is going to be ready so those things need to be in place...
Same with Covidity I guess ... things need to be in place before the first patient (on SKY TV)) gets dosed... it is this newsflow that is needed as is the opening up of the extra clinics for SCIB1 combo patients .... the time is surely now as H1 will be H2 before we knows it

I think from these articles about mRNA... it could well have never happened at all!.... no multi multi billion $ mRNA market at all... not because it doesn't work as now it does but because it took it getting backed supported and trialled .... a 50 year journey!... We know the hurdles Allison had to get over for his Checkpoint inhibitors to get to where they are now... multi multi billion $ CI market only set to expand x rate a year... redmile I like to think ain't stupid they will see the potential in scancell and what has gone wrong so far and are here to change that but if we start getting those all too familiar timeline slips I wonder what they will do, hopefully, something!...still a little time yet but yes modi 1 trial news needs to be coming in now SCIB1 combo finding a patient in one of the trial clinics and of course Covidity is go!... 100 day vaccines are us lol if only :)