Member Info for crumbs

It's not waiting it is - tick tock :)

Ray, it means Cobra is working with the Karolinska on their DNA vax

Brilliant to be in the mRNA game now :)

https://www.thetimes.co.uk/article/thousands-of-skin-cancer-patients-not-being-treated-vhgqwzvcj

'More than 100,000 people have missed out on being referred to hospital with possible skin cancer over the past year, according to figures that doctors and patient groups have described as “truly alarming”.

They said the result could be a rapid rise in people being diagnosed with more advanced disease, with some too late to treat.'

If we are indeed about to enter trial and COVs are causing the slowing down of easing lockdown it puts the Notts vax into focus.... especially if we get that all-important SKY first patient dosed with UK variants beating vaccine that could mean no more lockdowns ever! prime time news footage... You would think the Gov would perk up to it then!

It certainly was not an amount that meant it could be fast-tracked as 'insurance' insurance that we may now well be in need of and I'm sure the Gov was given an amount required and I doubt it would have been crippling probably around 10 mil or so to hire more staff etc to speed progress... anyways....

It is why though I'm happy BioNTech are winning because they are also a Uni spin out with science at its core...I'm sure they will spend their new riches wisely...

So now the lockdown release is at risk due to surprise surprise VOC's could never of seen that coming!.... You would think a variant proof vax would have been heavily backed from the beginning the gov has given the Notts team a paltry amount ...what for being the wrong university or something.

That Sally is not on SCIB1 anymore is telling that she is busy elsewhere.... good that we now have such a strong team where duties can be spread I'm sure Covidity trial is for scancell a huge task and we should always remember even with redmile/vulpes funds scancell compared to most others is on a shoestring to have 3 trials up and running is going to be a massive achievement .... BTW I've had to give the Astazeneca jab a yellow card... phew 6 hours after having it my blood turned to Nandos hottest sauce and I got into a ring with Mike Tyson in his prime and called him a clown!... Yeah rough pnly just getting over it and I'm far from the only one really made me appreciate 'tolerability' and not knocking its effectiveness or wish to put anyone off because clearly, it is a potent vax but the idea of having to go through that via boosters every so often... phew.... now if there were a jab that offered on one dose 3 years maybe 5 better broader protection.... yes acceptable.. It'll be another reason BioNTechs is winning the race with far fewer yellow cards... I'd hope Covidity falls in with those mRNA ones for yellow cards.... seem to remember SCIB1 trial had maybe 90% of patients reporting side effects none of those adverse and pretty much all and quite understandable Ichor related... another reason despite their tweet army Inovio are out of the race already.

Don't worry Lindy no doubts will be tuning in to listen to this and take note at the CIMT event ...

'As part of a dedicated COVID-19 - immuno-oncology cross-talk session, Ugur Sahin of BioNTech will deliver the keynote on the scientific journey of developing an mRNA coronavirus vaccine in 10 months.'

Thanks boom.... scancell do seem to like this event....

'2021 Scientific Planning Committee
Özlem Türeci
BioNtech, Mainz/Germany

Johanna Olweus
Oslo University Hospital, Oslo/Norway

Sine Reker Hadrup
Denmark Technical University, Copenhagen/Denmark

Marij Welters
Leiden University Medical Center, Leiden/The Netherlands

Sebastian Kreiter
TRON-Translational Oncology, Mainz/Germany; Head of CIMT Management Board

Mustafa Diken
TRON-Translational Oncology, Mainz/Germany; CIMT Scientific Secretary

Harpreet Singh
Immatics, Tübingen/Germany'

Hopefully, we will hear more about what these new research insights mean, scancell team science never sleeps.

A full update well well well overdue I'd say!
Obviously, we are in that period of just before so much newsflow could pile in at once but... certainly comms are down ATM

estimated 25 patients

Well done WTP no idea what your holding plan there is but for a longtime I wondered how can their mcap be so big not now I don't and reckon they could double it.... what a great potential scancell partner they could come to be ... certainly they are the winners for now out of the vax race.

Variants vid for kids and err me! :)
https://www.youtube.com/watch?v=ug0kHOmThWU&t=262s

Got all AstraZenca'd up this morning so far so good.... And a big shout out to all this great nations volunteers what a slick operation they have helped pull off.... We should cherish our NHS

Going from my speculating Sunday.... the Notts delivery could offer a potential another route for mRNA vax delivery too... delivery there currently using lipids which have issues around manufacture and patents plus not too sure if they will with repeated use cause adverse effects... that is an ongoing experiment that will play out as people have more and more shots... there is a possibility the body can build up a resistance produce an immune response against the lipids

So the Notts vax is super novel in so many ways that could have an influence beyond scancell

The truth is it was the other way round mRNA vaxs originally cancer vaxs just like ours ... another tick for the CEPI box I would say seeing as how those cancer vax platforms have turned out to be the best for beating covid too...

https://cepi.net/research_dev/our-portfolio/

you will find your answer there ... they have 2 preclincal vaxs already of course they must do there due diligence before committing funds for scancell that ImmunoBody has been through a trial must be a plus...of course that is fi we are in negotiations with them and my feeling is we are and they started about the time TGs CEPI Twitter storm ended which was pre their $200 million call... so it could well be like VBI ph1/2 initiated and CEPI funding news all at once....... though like others have said its no guarantee and till we know we don't certainly their $200 mill call ends the end of this month but I don't think that means that's when they decide they can do that any time they like before and after.... I'd like to think if it is the route chosen scancell are in with a good shout.

When the potential size of your asset keeps growing at the same time as demand increases.

' Demand for lithium, for example, is expected to grow 70 times over the next couple decades. But the supply from existing lithium mines and projects under construction can only meet about half the projected demand this decade.

“This mismatch is something that worries us,” Fatih Birol, the executive director of the IEA, said at a press conference today. “Our numbers show that the critical minerals are not a sideshow in our journey to reach climate goals. It’s a part of the main event.”

Batteries for electric vehicles (EVs) and renewable energy storage are the biggest factor driving the potential mineral shortage. An EV requires six times more mineral resources than a car that runs on fossil fuels. Cobalt, nickel, graphite, and manganese are essential for batteries, too.'

'the IEA expects a shortfall unless new mineral deposits are tapped. Production of new critical minerals isn’t ramping up fast enough because investors aren’t convinced that world leaders are fully committed to their climate goals, according to Birol.

“If they get from the governments unmistakable signals that clean energy technologies are the technologies of tomorrow, then I believe this investment will flow,” he says. Until then, limited supplies of critical minerals will loom large over any global action on climate change.'
https://www.theverge.com/2021/5/5/22421081/critical-minerals-climate-change-goals-clean-energy

So VBI story seems to be they got $56 million CAN in August last year from the Canadian Gov to progress their covid variants of concern vax then they announced March 9th this year initiation of ph1/2 trial ... and then the next day March 10th CEPI announcement of $33 million funding and collaboration ....not sure if anyone has actually been dosed yet though.

Actually their funding came March this year and didn't seem to do much to sp there