Member Info for crumbs

And this is absolutely it....

'The recent rhetoric will not discourage us from continuing investing in science. But I am not sure if the same is true for the thousands of small biotech innovators that are totally dependent on accessing capital from investors who invest only on the premise that their intellectual property will be protected'

Biden has hurt the scancells of the world not the big pharmas... yet no innovative biotechs backed by investors will to take the risk/rewad.... no innovations!

Luckily this patent waiver is going nowhere but it puts us back to going nowhere too lol Come on scancell lets be having the trials and if not let a little Indian Factory that gets huge charity funding take them on so we can all at least have some trial to be excited about :) before all UK is vaccinated and our trial cohort will be newborns... though I notice there have even been trials in that cohort already!

Sends out a letter.....

'And I would like to make a final point. I worry that waiving of patent protection will disincentivize anyone else from taking a big risk. We deployed $2 billion before we knew whether we could successfully develop a vaccine because we understood what was at stake. Just recently, I authorized spending an additional $600 million on COVID-19 research and development that will bring our total spend for R&D in 2021 to more than $10 billion . The recent rhetoric will not discourage us from continuing investing in science. But I am not sure if the same is true for the thousands of small biotech innovators that are totally dependent on accessing capital from investors who invest only on the premise that their intellectual property will be protected.'
https://www.linkedin.com/pulse/today-i-sent-letter-have-candid-conversation-our-drivers-bourla
Indeed!

Yes I'm sure he will get lots of American criticism for this... he is just playing to a certain crowd here the ones that think pharma hold back cancer cures and even create desease for profit profit profit...
Pharma deserves criticism but this is the wrong sort as it goes after the innovators the Sahins the Lindys etc ... And us the ones that back the risk so the word gets the best tech.....

Mans an idiot I've decided lol..... BTW he probably needs some innovative medical treatments himself ...bet he would not go for the knock-off mad in Vietnam version of it though

'any ideas on when we might get news of a trial kick off?'

Within weeks :)

'However, this host cell entry was not blocked by the monoclonal antibody Bamlanivimab, which has received emergency use authorization (EUA) as a COVID-19 treatment.

Finally, B.1.617 also partially evaded neutralization by the antibodies induced through natural infection or immunization with the Pfizer-BioNTech BNT162b2 vaccine.

Markus Hoffmann and colleagues say that antibody evasion by B.1.617 may contribute to the rapid spread of this variant.'
https://www.news-medical.net/news/20210506/Indian-SARS-CoV-2-variant-shows-enhanced-host-cell-entry-and-immune-evasion.aspx

And The Indian Variant is here already..... Let us hope no more lockdowns but until we have more universal vaxs there is no guarantee... so let's support those working on such vaxs and not bash them by threatening their IPs.... not seen a cent of US gov money go into backing Covidity a potential answer to a still very urgent question.

Yeah just logic really but this is damaging no doubts about it because it is just political play of lets blame evil pharma...

oh yeah well pharma are big profit making machines but what lays under is a lot of hard lifetimes of scientific endeavour .... That often comes from tiny bios like our own that do not deserve this bashing.... we investors take the risks so the world gets the best possible vaxs ... its as simple as that ... no investment in protected IPs you get no mRNA vaxs no Checkpoint inhibitors.... nothing! And its funny how the whole world wants those vaxs

Impossible to call it kinda looks like a sell but SP finishing up probably means it was a buy as surely such a big sell would have put us in the red.... one to watch as that was a big trade!

Moderna shares up BioNTech shares up ... Scancell shares down yet we were least likely to be hurt by this Biden non starter... lol we haven't even got a Covid vax in trial yet! Nevermmind approved and commercial lol .....

'EU leaders are likely to hear advice from the bloc's executive, the European Commission, that a waiver would not help boost production, especially in poorer countries, as the manufacturing process requires advanced technologies and facilities, officials said.

The U.S. firm Moderna waived patent rights in October on its vaccine, which uses using the latest mRNA technology, but no other firm has yet announced that it will try to copy the shot.'

You can't simply get the ingredients that are hard to come by and then go off a patent recipe and make these vaxs...

For someone (Indian factory) to take Covidity on for instance would probably require more funds than scancell themselves have ever had ... they probably would have a trial by now though for us all to be excited about lol

WTP... most of them won't of thought it through before making initial noises but after further thought and listening to sensible advice I'm sure they realise it's just a bad idea I hope Boris chooses the right side

Of course, its political posturing because out there is the notion of Evil Pharma who need punishing.. oh really like the brilliance of Sahin and co needs punishing!!

This is brilliant from our fave science blogger and whole article worth reading:

'All That Money
I realize that this talk of IP waivers comes, as fate would have it, while some of the vaccine companies are reporting earnings on the vaccines themselves. Pfizer, for example, has said that they may well have $26 billion of sales of the vaccine that they developed with BioNTech. And while I don’t know what the actual profit will be, it’s going to still be a lot. Allow me to be offensive: good for them. 26 billion is a small fraction of the economic damage that’s been done during the year because of the pandemic, and these vaccines are really the only way out of it. Add to that the incalculable social and psychological damages, and it’s a damned cheap price for all of the vaccines put together. Remember, there was no guarantee that any of these things would work – several large and very competent drug companies (Merck, GSK, Sanofi) failed in their own vaccine efforts.

The vaccines that have worked have been the result of years of work by both academia and industry. Both of these groups have hoped to profit by their efforts. And as I never seem to get tired of pointing out, a lot of that work went into discovering things that didn’t work. RNA constructs that fell apart or didn’t produce much protein. Formulations that didn’t deliver, or were toxic. Viral vectors that weren’t worked-out enough, or couldn’t be produced in sufficient quantity. Genetic payloads that weren’t written in quite the right ways. So when something finally does work, I am all for being able to profit from it, and to cheer on the people who are hoping to profit from the discoveries that are working their way through the academic and industrial labs now.'
https://blogs.sciencemag.org/pipeline/archives/2021/05/06/waiving-ip

Macron not supportive of it either ....Looking more and more like a dead duck.

'Emmanuel Macron has echoed the German government’s concerns over Joe Biden’s proposed suspension of intellectual property rights for Covid-19 vaccines as he urged the US and the UK to instead start exporting doses around the world.

Arriving at an EU summit in Porto in Portugal, the French president expressed his reservations about the White House proposal to waive patents and criticised the lack of exports coming from “Anglo-Saxon” countries.

“What is the current issue?” he asked. “It is not really about intellectual property. Can you give intellectual property to laboratories that do not know how to produce and will not produce tomorrow? The main issue for solidarity is the distribution of doses.'

What US could do is invest zillions in vaxs both development and manufacture and then fairly distribute them... patent waiver a distraction and political' good guy gaming ' and seems to have won Biden plaudits ... will it actually save a life? doubt it ... chucking millions at a Covidity etc could though

CEPI/Covax is the way!

One thing is for sure from reading scancells patents I could never come up with a Covidity and doubt anyone else could though like I say probably some little factory in India could in 2 weeks :) it just would not be Lindys Covidity lol...

Storm in a Teacup and if its that that has caused sp drop ... a joke ...Cheers POTUS

Well, as far as we know they ought to have manufactured those plasmids now seeing as they say they can do it in 6 weeks....

What do you mean?

'President Biden’s support for the WTO's proposed temporary waiver of Covid-19 vaccine patents has certainly put the cat among the pigeons, hitting stocks of coronavirus vaccine manufacturers in early trade. But just how real a threat the waiver is to vaccine sales is debatable. On Moderna’s earnings call this morning chief executive Stéphane Bancel told investors that he was not losing sleep – and well might he slumber. In October the group said it would not enforce patents around its Covid jab; in the ensuing seven months no one has used the tech, Mr Bancel said. It is one thing to have the formulation for vaccines, but a very different one to produce them, especially mRNA shots. A shortage in manufacturing capacity and professionals with knowledge of mRNA production provide very effective barriers to entry, before considering the lengthy processes involved in building new facilities and winning regulatory approvals. Any potential sales would therefore be years away. Additionally, it is far from clear that future patents will be waived. Developers are already working on jabs for variants, and Moderna itself is studying multivalent vaccines. As such the share price reaction could well turn out to be a storm in a teacup.'

Even if it happens Modernas CEO is not losing sleep about it... its no simple thing to manufacture these vaxs

'"While this is a negative headline," said Morgan Stanley analysts in a research note, there is no mechanism "to force management to teach other manufacturers how to make their vaccine, suggesting no change to the status quo."

Moderna, which said in October it would not enforce patents on its vaccine during the pandemic, noted the lack of companies able to rapidly scale up complex manufacturing of a similar vaccine to meet surging global demand.

"They will have to go run a clinical trial, get the data, get the product approved and scale manufacturing. This does not happen in 6 or 12 or 18 months," Moderna Chief Executive Stephane Bancel said on a post-earnings conference call.'

Can't see this ever happening ... though reckon a little Indian factory would have had Covidity made and in trial by now :)

'In fact, based on our current lithium mining capacity outlook and the share of lithium demand that electric passenger vehicles will create, we estimate that the supply deficit is poised to delay the production of the equivalent of around 3.3 million electric vehicles with a battery of 75 kilowatt-hours (kWh) already in 2027. The impact will grow quickly, to around 9 million EVs in 2028 and some 20 million electric cars in 2030.

“A major disruption is brewing for electric vehicle manufacturers. Although there is plenty of lithium to mine in the ground, the existing and planned projects will not be enough to meet demand for the metal. If more mining projects are not added to the pipeline quickly, the energy transition of road transport may need to slow down,” says James Ley, Senior Vice President at Rystad Energy’s Energy Metals team.

In addition to electric passenger vehicles, the expected lithium mining capacity deficits will also disrupt the production lines of other vehicles that will be fully or partly electrified and need batteries, such as buses, trucks and hybrid cars. Demand from the shipping and aviation industries, as well as grid storage, will also feel the scarcity of lithium.

Although lithium-ion is not the only battery technology, it is far superior in EV applications and won't be substituted by anything else this decade. Even if other technologies evolve later, they too are likely to use lithium, although maybe in smaller volumes. Lithium is the lightest metal applicable to batteries and switching it with something else would reduce energy density, resulting in shorter ranges for EVs.'

https://www.rystadenergy.com/newsevents/news/press-releases/millions-of-electric-vehicles-may-face-production-delays-from-2027-as-lithium-mining-capacity-lags/

'The Seychelles, which has fully vaccinated over 60% of its population against Covid-19, is bringing back restrictions amid a rise in cases.

The archipelago of nearly 100,000 people recorded close to 500 new cases in the three days to 1 May and has about 1,000 active cases.

A third of the active cases involved people who had had two vaccine doses, the country's news agency said.

The rest had either had a single dose or were unvaccinated.'
https://www.bbc.co.uk/news/world-africa-56992121

What a worry......

City v Chelsea final.... ought to come to Wembley in a sensible world!