Member Info for crumbs

To my mind 3 possibles:

1. CEPI... we know they know but we do not know if scancell have gone for it... I suspect they have
2. Pharma ... we know BioNTech know we know Pfizer have shown themselves to be a wolf of a partner to them we know other pharma will be interested.
3. Go it alone... we know we have enough to run a ph1 we know the situation is VOCs are threatening the end of lockdowns .... most high risk option but on success........

I think though others shoot you down it's ok to speculate about where we are at and what is happening ......
So this is my speculation:
Scancell are in a lot of talks and most probably one if not the one is with CEPI... they just seem to be the best fit they do not take your IP away but they back your science all the way and they are becoming a global powerhouse in every aspect of Vaccine development, manufacture,trial and delivery.... yes it may well mean you having to give in this case covid vaxs away at cost but you get your otherwise overlooked even ignored techs proven for free -IP intact... in scancells case proving up 3 techs would be totally huge ... the potential Avidimab market .. wow... immunobody used all around the world wow... and the delivery... well if it came inhouse it is also huge with many potential applications... So I like to think we are high in the mix of applicants for the CEPI Call and being UK based is a plus and having such a team and resources as team Notts has is a plus...

and the silence is... well loud.... from Monday I think the chance of hearing more becomes much much more likely... but scancell would have so much to gain from their tech/s being backed by a CEPI... again IP intact and in scancells case 3 pieces of game-changer IP panted techs... proven for free all the way to full use at a rapid pace....Would I think in current climate of we need insurance vaxs climate be rather sp exciting, well the zone gets entered just about now Lindy estimated the trial to start in Spring and the CEPI is closing.

'How Speeding up Science Aided the Fight Against COVID-19'

'Coming Soon'

lol

There looks to be a lot of good reading there nom cheers :)

The SK Cepi deal is not part of the $200 million CEPI call...
Sk are an interesting one this funding news seems to have hardly affected their sp ... I think they are slightly up they are valued in Korean money so in currency converting to quids I think they are valued at about £7 billion mcap? anyways it certainly seems the covid vax plays are of more sp worth to smaller players who get backed....

Spring ends June 21st I believe

I got a print copy of this in the post today... must be due to me giving a crumb sized donation :)
Anyways page 20 you want to look at.
https://www.nottingham.ac.uk/impactcampaign/documents/ambition-issue-2-2021.pdf

'The CfP is divided into two parts with varying timelines. The broadly protective vaccine against SARS-CoV-2 variants
(BPCoV2) should have a minimal Target Product Profile (TPP) that aims to prevent disease1 caused by circulating SARSCOV-2 variants of concern and emergent variants of interest (in aggregate referred to as ‘variants’ herein). The BPCoV2
application will require one step, the submission of an Expression of Interest (EOI). As these vaccines have the potential to
help tackle the ongoing pandemic, as well as avoid costly and time-consuming strain adaptation, a more aggressive
timeline for their development will be sought. Established and proven vaccine platforms are desired that facilitate rapid
development and offer significant manufacturing scale up potential and access to vulnerable populations with potential
Lower and Middle Income Country (LMIC) manufacturing. The BPCoV2 call is open from April 1st to May 31st
, 2021. '

Monday it is... Of course that does not mean the vaxs chosen if any are announced then though I'd expect with the words 'more aggressive timeline for their development' we may hear soon .... Again no idea if scancell have applied but seems probable and no idea if we meet CEPIs criteria... but if not then who! lol ... anyways we will find out .... but gosh how we need more aggressive timelines for development here!...actually that could be what puts scancell off applying lol....

49 hospitalised in Bolton with Indian VOC 5 of whom were double jabbed with current vaxs...
Some think a slow couple of million begrudgingly tossed at the Notts team was the Gov showing good foresight well not me!
Time to fully back insurance vaccines.... CEPI call ends in 3 days...
I did not think that 400k was a Diggle wiggle and am glad it was not... like to think it would have been too close to news.

To end the pandemic... it comes with a $50 billion pricetag but considering the cost of not ending the pandemic....

Anyways the part where scancell fit in is in 'insurance'

'https://blogs.imf.org/2021/05/21/a-proposal-to-end-the-covid-19-pandemic/
'4. Make at-risk investments to diversify and increase vaccine production capacity by 1 billion doses in early 2022 to handle downside risks in 91 low- and middle-income countries, including from new variants that may require booster shots. [$8 billion]

5. Scale up genomic surveillance and systemic supply chain surveillance with concrete contingency plans in place to handle possible mutations or shocks to the supply chain. These plans should be prepared with the participation of multilateral agencies, vaccine developers and manufacturers, and key national governments. [$3 billion]'

I don't think it is Diggle.... we will see

Yeah, you are also inanaco in disguise :) ... take that as a compliment too :p

https://www.nature.com/articles/d41586-021-01372-6
'NEWS 21 MAY 2021
Scientists zero in on long-sought marker of COVID-vaccine efficacy
Data from seven vaccination trials help to identify a blood marker for protection against the disease.'

;But if vaccines can’t be assessed through placebo-controlled trials in future, how can we know if they are effective?

“CEPI set up its centralised lab network back in October to address this very challenge”, explains Valentina Bernasconi, Preclinical and Immunology Scientist in CEPI’s Vaccine R&D Team and Project Leader of the Centralised Laboratory Network. “Our network of labs—which is open to all COVID-19 developers—will help to harmonise evaluation of the immune responses generated by multiple COVID-19 vaccine candidates. This will help researchers establish reliable markers of immunity, like how high antibody levels need to be to neutralise Sars-CoV-2, which will help regulators assess the efficacy of various vaccine candidates in the absence of data from placebo-controlled trials.”

Establishing these blood markers, in particular, could help researchers collect the data needed for regulatory review of next-wave vaccine candidates or existing vaccines that might be tweaked in response to the emergence of new virus variants.

CEPI is working with regulators, researchers, and manufacturers around the world to determine what immunological data will be necessary for regulatory review of future COVID-19 vaccine candidates.'

3. Loss of vaccine effectiveness will result in further economic and social costs.
4. A solution is to update vaccines to keep pace with virus evolution, and the newer, more
flexible vaccine platforms are particularly suitable for this approach.
5. Additional potential solutions are to invest in developing new vaccination strategies that
could induce stronger T cell responses since T cell epitopes might vary less over time.
6. Another strategy would be to search for more broadly protective vaccines, including
universal vaccine candidates, multivalent vaccines, and heterologous prime-boost
strategies
https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/988226/S1226_Setting_up_medium-_and_long-term_vaccine_strain_selection_and_immunity_management_for_SARS-CoV-2__1_.pdf

Thats the thinking of some in or close to GOV...
Well that was available last April...as it screams COVIDITY!

Anyways no need to panic the planets are aligned and obviously some want sub 20p :)

A little more patience of course I agree comms could be better but also know they must be super busy and have not got anything RNSable since last update so...
BTW in Vox Cliff only said ASAP no set timeline

Simple, more funds would have = more staff more time to be spent on Covidity the project progressed faster scancell has many techs to progress all on a shoestring budget this has been a major issue and why redmile saw the opportunity to turn the tide... yes indeed funds they have are enough to 'initiate' a ph1 and that is where we are at I also expect we have applied for more funds from any sources available CEPI being prime...

My gripe is more look at the situation now... VOC's rampant... it only takes one to fully elude current vaccines and back into full cost the economy a fortune lockdown... yet you think £2 million quid was fair thinking insurance lol... no it was not!
They are spending loads- tens of millions- on this porton down project...hmm

Anyways onwards the newsflows should be close now and I reckon once the ball is rolling it could roll rapidly in scancells direction.

I suggest the best timelines to go off are here in the Turner pope presentation page 9
https://www.turnerpope.com/wp-content/uploads/2020/12/Scancell_Holdings_plc_19_11_2020_FINAL_BGv3.pdf
These are the timelines that will have been given to redmile.... you can see we are not quite there yet for the modi1 and Covidity trial newsflow ... though close.
SCIB1 combo though we know through our own looking is making some progress as far as trying to get that trial recruiting it has so far failed to meet the expected timeline... I would expect modi 1 to have an easier time in recruiting... what happens with Covidity will be interesting as probably even un conceived UK babies will be vaccinated by time it is ready to go! :)

Again it is my personal opinion that UK gov failed to fully back and push Covidity.... Proff Ball said as much in a tweet answer... Covidity is behind due to waiting on funding ...

'Proper Democrat
@ProperDemocrat
·
13 May
One of the main differences seems to be that their candidate vaccine has been through phase 1 trials and yours has not. Why is that, given that the work started last March?
Jonathan Ball
@JonathanKBall
Replying to
@ProperDemocrat

@InovioPharma
and 3 others
Funding wasn't released until October....'

AvidiMab might be better at binding his wallpaper to the walls of no 10 than whatever he used last time too :)

'We can safely say that our government know exactly the global worth and prestige of a successful Covidity Platform. Boris and Co would be jumping up and down at the news of the first workable Universal Vaccine hailing from the UK.'

I'm not so sure of that Chester.... £2million lol ... that was not the GOV being serious about the obvious need and potential of what the Notts team are working on with a frayed shoestring of funding... they need to back it more seriously and that could well happen next combined with potential CEPI backing too... this recent document definitely sings our song as it were...

Got to be getting close to the newsflow I reckon your timelines are right and if we tie in Diggles latest wiggle. (he owed us that one).. the close of the CEPI call by May 31st etc...

Really would have liked modi 1 trial news by now that ought to be very due now ... anyways the potential does not diminish :)

I'm certainly heartened by the fact BioNTech are fast on their way to becoming a big pharma themselves with $billions to do deals with from their Covid vax race winner -so far- winnings ... As of there is one pharma that 'gets' scancell it is them and we know they know :)