Member Info for CHELSEA7

Opening 7/7.50.........MMs will take 200k shares at 7.20

So MMs want shares, normally increases as the day goes on, lets see some buys roll in!!

"""Just MO but I don't think it possible to read anything into the early AGM and last week's news was not good - the SCIB 1 Combo trial seems to have been downgraded"""

Where does the Combo Trial seem to be downgraded. To get the trial started the U.S. arm IND will have to be re-applied for. Sounds simple to me. The SCIB1 mono trial which caught the eye of Keith Flaherty and that was U.K. based, so why was last weeks news not good.?

.* Hadn"t seen this before, a good read)......................guess what I meant to say was it is a good listen, and just a few minutes long.

There are a few well written pieces on twitter generated from last weeks news. I suppose I just missed it.

Anyone remember when the last lot of options were granted to the BOD?? I seem to remember the price being 22p, can"t recall the expiry date though. Just another target I would love to see reached, c"mon CH lets get the inflection points out there!!

Morning Guys, another interview found on Scancell twitter between Cliff Holloway and Andrew Scott, discussing in some detail the IND situation and welcoming Scancell back into trials. Hadn"t seen this before, a good read......................

SCANCELL Retweeted

Andrew Scott
?

@AndrewScottTV
Aug 19
More
*VIDEO*
#SCLP @scancellpharma

#Scancell back in the clinic with a phase II trial of its flagship skin cancer treatment

Welcome back everyone, to a nice clear blue day!!!

Yep rats, it is an enticing thought, London buses in action, and that is just trials,

I know many of us are just arriving home from the weekend, but I am reakky interested to hear your thoughts as to where we are now as we arrpoach the AGM. Does anyone still feel the SP doesn"t have a chance of a fast morning rise taking us very north, or whether it is other news that will secure that.

I did feel last week we got plenty of news as to where we stand now and am grateful for that, it seems to me we have a great launch pad for further good news, unhindered by a few booby traos that always seem to rear their ugly heads, and it has been sone time we could say that.

I also find it astonishing we can have two trials running in 2020 with just a M/Cap of £34m. Even more remarkable ids the prospect with SCIB2 of having three trials running together all in 2020 and that is not all as we have the glycans/Mabs and Biontech situations which could bring us very good news too. Only asking as we are pretty quiet tonight, no doubt getting us orgnised for the week head, but is there anyone who feels we are not getting close enough yet to moving away from single figures?? So will good for many others to share their thoughts, , tomorrow.

Would surprise me none to see Mms just taking 50k odd shares in the morning, was 200k Friday, and a steady increase during the day, that has been played out most days in the last few weeks, but hoping above all we have our buyer around building on vastly improved holdings.

Catch yer tomorrow guys , will try and gt bck to my internal 7.00 alarm clock, I can feel, and smell news at the monent. Goodnight

Thanks langtro, I thought it was the TECA BB, so good to know the right place!!

Well done all you guys for keeping the TECA BB going so well, Wassatt would have wanted that, andthe sadness is replaced by knowing he is out of pain now, and keeping an eye on Troajan, lol. Take care buddy.

cont:) he will be sadly missed by many. Nomlungu i have seen you posting there in recent months as a few of us often did.

His most poignant post after being hospitalised the last four weeks of his life was his final post on the 5th August.........................Wassatt

Posted in: 0QLN

Posts: 82,791

Price: 251.55

No Opinion

""Sorry Tecass05 Aug 2019 08:56
I've got the shakes so won't post much at the mo"" We all knew that was the end and indeed it was.

So after a truly wonderful Bank Holiday Weekend, i hope it was for you guys too, the market opens in the morning again, the MMs were struggling to get many shares last week, a feel feelings our buyer is back, especially with the 5ook buy on Monday on a day we opened down 6/7p but still manged 3 v1 buys. We clawed that back by Friday, where do we go from here, well over and above 8p by the AGM is just MO, lets see how we go.

Goodnight guys.

Also posted in Scancell Twitter on the day the Financial Report was released 20th August............................

Scancell Holdings PLC (LON:SCLP) described the 12 months to the end of April as a “busy and productive year” – one in which the building blocks for the clinical development of its two lead drugs were laid.

Alongside its prelims, the company confirmed manufacturing of its Modi-1 vaccine for solid tumours, developed from the Moditope platform, is progressing well. As a result, it expects to be able to begin clinical trials in the first half of next year.

Its lead drug, SCIB-1, developed from its ImmunoBody technology, has recently entered a phase II clinical trial here in the UK.

The study will initially assess the safety and efficacy of the treatment in 25 people with a metastatic form of skin cancer, melanoma. SCIB-1 will be used in harness with Merck’s checkpoint inhibitor Keytruda.

Scancell remains in discussions with regulators over the minutiae of a parallel clinical assessment in the US.

A £3.9mln injection from the life sciences fund Vulpes will effectively bankroll the latest R&D.

As is common with drug developers at this formative stage of their development, the group was loss-making. The deficit for the year was £5.6mln as development expenditure grew to £4.15mln.

So there we have it in black and white............"".Its lead drug, SCIB-1, developed from its ImmunoBody technology, has recently entered a phase II clinical trial here in the UK""................Will Scancell announce first patients dosed or all patients dosed?? Well IMHO I think from a PR perspective we indeed will, and if that is achieved before the AGM then all the better for all involved. I personally feel that will have a tremendous "mood tune" effect on shareholders, the industry and future investors who have been following us for many years waiting to see us re enter clinical trials.

So as we know an exciting chapter is beginning, news of the MOD1 trial will come anytime and there is a strong possibility we can have three trials running in 2020, the third being the CRUK sponsored SCIB2 combo trial, and all that for a company with a M/Cap of just £34m!!! Can anybody think of another tiny AIM Bio with three trials running on just a M/Cap of £34m?? I can"t!!

Two weeks ago LSE lost a fabulous poster and a tremendously nice guy Wassatt, often found on the TECA BB and just about always leading the top recommended charts for many years. He managed to amass 87k posts during his membership, and for the last few years of his life he found great solace in posting to his pals on a very interesting BB. We shared a number of posts on the Premiun share chat facility, two in particular still make me smile when i Overtook him twice,. We rarely discussed our cancers his was pancreatic but we knew we could relate to one another totally. So anyone fancy leaving him a message tomorrow is his day, a gentleman, a class act, knowledgable and he wil

Showing on Scancell twitter August 21st. Some useful information.........................

https://www.trinitydelta.org/companies/scancell/

Morning Hanoi, yes I think it is an area where we can improve, the last thing we want to see is receiving RNSs and debating whether the information is correct. Well that is how I felT about the trial being linked with the FDA granting the IND.

Just very occasionally getting out this year, this summer has been very humid here in London, so breathing is the issue, just happy to be wherever I am and comfortable.

Well I only watched day four, didn"t have a clue we got bowled out for 67. I guess I prefer to watch the limited over game, and with 70 odd runs needed for the last wicket partnership that is indeed what we saw. Immense performance from Stokes and Leach, Stokes had that look of being zoned in to another place, delighted.

I often say the Oncology market has gone through monumental changes in the last three years, that is true, but in this article dated back in 2015 RG shares his thoughts, that was four years ago now, and it has taken that time to get where we are now, as the Combo Trial is about to be launched, finally. A really interesting interview............................

https://www.futuremedicine.com/doi/pdf/10.2217/imt.15.67

Evening Ipad, well that is the one sport I am not really into. We never played it at school, but I never did fancy at least a 1.000 lbs of human flesh clawing all over me!!

Just a one page Scientific Paper on the forthcoming SCIB1 trial. Haven"t seen it before, but very understable and easy to read............

https://www.scancell.co.uk/file-manager/scientific-papers/pivac-scib1-plus-checkpoint-inhibition.pdf

Well done Ruck. it was only due to your post yesterday that I tuned into the Test Match this morning. What an amazing game, certainly one for the memory banks. Feeling rather old being reminded it was forty odd years ago that Botham won that special Test Match. Where have the years gone??

Pretty excellent weekend too, 3 points at Norwich, glorious win against the Aussies, a few hours of fabulous sunshine, great company and spent nothing!!, lol. Got nothing much to say about Scancell that hasn"t been said this week, so back to enjoying a lovely weekend. Take care guys, and thanks again Ruck.

Chester, interesting nobody added to our posts this morning and I rather thought it encaptured the thoughts of many.

I keep reminding mysely that I don"t thimk we have ever been in such a position for a series of good news, and now the details are out re the IND I can"t think of any more points that make me feel any different.

So a goodnight all, a good day for me today, thoroughly enjoyed seeing my team win their first game of the season, heres to plenty more.

Thanks Martc, I saw that post this morning, didn"t have the heart to correct it, and forsight thanks for the advice, but in all honesty after six years I don"t think I have the heart to undergo any more treatments. I know from experience there are many who have had far harsher treatment regimes, and still not made it, it is such a random disease and they are still learning how similar cancers mutate into a life of there on. That is the hardest part you never know which way it is going, and mentally it can tear you into two. That is an aspect of cancer we don"t hear too much about, it is a life changing experience.

I noticed someone mentioned UCLH, not sure in what context but G-d forbid you or anybody close to you is diagnosed it is important to get into UCLH, Guys, Barts, all the hospitals in the London Trust, simply because they have all options of treatment in house, UCLH for example is opening a huge hospital near by for Proton Treatment which opens in 2020, particularly for cancer in bloods, and an Immunotherapy centre which is at last being recognised as a proven treatment. It is true too many are still not making it, but true also more people are enjoying an extension to life, every year they are gaining more knowledge, one day they will make a huge discovery a bit on par with the work of James Allison who won the Nobe l Prize two years ago for his work on T.Cells and their importance in fighting cancer. I have no doubt the enormity of improvement in treatments has been so much the last few years it is harder for companies like us to even stay in the race, especially on the budgets afforded.

Yes there is a need for compounds like 401 if they can show they can stop the cancer spreading enough to work in Combo with checkpoint inhibitors. That is the way the market is heading, even Keytruda the biggest selling drug is in many combination trials, with Keytruda working on the T.Cells. I don"t think the market has even valued that in, tell me are their any positive signs of future funding, it is as dependant as that. As I say good luck, even treatments that tick a few boxes are valuable to Big Pharma and the current M/Cap is tiny. One for the brave!!

Yeah, pleased with that win.

I agree, that is what I always thought, no obvious reason to think differently. I have a feeling someone will be asking that question at the AGM!!

""none of us thought that the permission to start was linked to the FDA / IND""

As loathed as I am to go backwards, that still niggles me and makes me question what the purpose of news is . Was it really necessary not to have made that known to us? After all it has taken over three years to get this far. Surely if we are told the patients will be chosen in the coming few weeks, it should say ""subject to the IND being approved, and if there is any further delay in it being granted we will start the U.K. arm in that timeline"" I cannot see that would have caused any panic and it certainly wouldn"t have if were told that two years ago. After all it has been a cloud hanging over us for a very long time, simply ""Why is the trial taking so long to start"?? Maybe we will find out in the months to come, maybe we won"t but doing this way does pose the question "why"?

But as you say chester.." Just shows that we only know a fraction of what's potentially coming next."" I think that is always the way, especially when you spend so long in clinical development. I guess that is why I am looking forward to the AGM so much, not so much for any spectacular news but for clarification of timelines from where we are and further news of progress from our existing pipelines.

Yeah super confident we will get news that trial has began by the AGM, especially as it seems it is discretionary whether Scancell announce it or how many patients dosed, so I think that will give us all a buzz to hear that,

Hi Troj, how are you doing mate, sending my best.