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Pharmacokinetics (PK) represents “what the body does to the drug,” whereas pharmacodynamics (PD) can be defined as “what the drug does to the body,” or, more specifically, to target cell-types, tissues, or organs.

Read this: https://www.sciencedirect.com/topics/medicine-and-dentistry/pharmacokinetics

Was happy to invest November's OEIC dividends just now.

NURSE!!! He's turned CapLocks back on.

And this returns 2 results, two different trial drugs.

https://www.mskcc.org/search#q=ava6000&t=All&sort=relevancy

Richob, this

"(2) to go beyond Cohort 4 with a fifth dose escalation."

Everyone should know that if RAH gets pulled up for posting crap, which he does a lot, he filters/blocks you! Fragile ego!

This bodes well. Phase Ib, I think.

But 'fifth' dose escalation? lol

So ****_nibbler sprayed all that out without any mention of the patent FAMILY. The US has a very weird patent system with patents able to continue in part, claiming the priority of the earlier patent being continued. No doubt this all relates back to the 2015 patent which is now granted - i.e. is in force as long as the annual fees are paid.

Do you know whether there is patent protection specifically for the other pre|CISION drugs?

I don't know when FAP expression ceases during development (growth), but FAP abundance in tumours is always compared to healthy ADULT cells.

The Numskulls?

Is FAP overexpressed in brain tumours?

It's in for a December upgrade. Will come bouncing out with predictions everyone can believe in ...or not.

Well intuition is one thing, but he doesn't 'know'. Or if he does, then he has an insider knowledge And he has a trading account, as he has said himself.

"DE 5&6 will add 6 months. Worst still, provide no confidence they’ll be done, then. Over 2 years to complete a P1a?? Ridiculous without a plan/reason.

"I’ve been critical of AS’s communication in the past. DE5 with a ‘progressing well’ would be the first time I would consider this investment."

What happened to DE4? 'Christ on a bike' [eye roll].

"Myles’ tweet was as strong a hint as I’ve ever heard him state. Im expecting a positive update."

Why (and what?)? He's a private investor.

https://www.youtube.com/watch?v=YMNEozyzpZI&ab_channel=ABKCOVEVO

Like hanoihank, I suspect this is the process they are developing, not a description of where they currently are.

Nah, just a filter

LEAK!!!