RE: T Minus 10 Days & Counting15 Dec 2022 11:46
DTW & crypto,
Given that Avacta have RNSed all previous DEs, there are two possible reasons for the lack of news about the trial:
1. The dosing of cohort 4 is still continuing at 200mg/m² and there has obviously been delay that, as previously, we don't need to be informed about.
2. The dosing of cohort 4 has completed and any remaining biospies are being assayed; the complete data set is being cleaned, analysed and put into presentation form; and the RP2D decided (and hospitals lined up).
There may or may not be a further DE but that would come after cohort 4 completes.
Cancer doesn't stop for Christmas so news, particularly relating to a further DE, could drop at any time.
I do think AS needs to make some sort of announcement about why, having flagged it up since June, there was no Science Day in November. Whether that is part of an RNS, news on the website, a mention in an interview or by the medium of interpretive dance doesn't matter. AS's credibility and, by extension, his integrity does.