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I'd take a coordinated buy out at $1.72tn. Would make me a billionaire...

One thing that is instructive, as illustrated by that trial, is in the summary but there is more detail on slide 13 here: http://ir.crisprtx.com/static-files/bfba41c6-5c28-4681-9002-bdfcef21c3f7

The Dose Levels are Cell dose (CAR+ T cells)
N is te number of patients in each cohort

DL1, 30x10(sup6), N=3, Overall response: Inactive. A big zero.
DL2, 100x10(sup6), N=3, Overall response: 1 (of the 3), (33%)
DL3, 300x10(sup6), N=6,Overall response : 3 (50%)
DL3.5, 450x10(sup6), N=6, Overall response: 4 (67%)
DL4, 600x10(sup6), N=8, Overall response: 6 (75%)

The same trend for Complete response.

The increases were 3.3x, 3x, 0.5x and 0.33x, i.e. big increases until an effect was found and then decreasing percentage (but constant level) increases.

Contrast that with the AVA6000 dose levels:

Initial: 80mg/m²
DE1: 120mg/m² (0.5x increase)
DE2: 160mg/m² (0.33x increase)
DE3: 200mg/m² (0.25x increase)

These are decreasing percentage but constant level increases, which indicate that it was working even from the initial dose level. As also supported by promoting AVA3993 to preclinical and all the other indications of success we have witnessed since.

It'll just be news of DE4. Ra! Ra! Ra!

Never seen one of these before and don't know whether this is typical. It does seem comprehenive though!

http://ir.crisprtx.com/static-files/c1419057-b161-4335-a003-41ff46a44bdb

7am Wednesday 11th

No need to thank me

That has been in the protocol since the beginning.

Tasers primed and set to Stun...

For that reason, if Alan and Fiona and Neil are going to San Francisco for Monday, 9th then I should think the RNS will come out Wednesday or Thursday next week. Thursday, with embargoes should catch the weekend news schedules.

Not a bad return for a company making widgets.

An objective ($40bn) should always include a deadline otherwise it is just talking crap.

$40bn in twenty years time perhaps? If not taken out before then...

NCYT and ABDX spikes were ridulous. If there's any money for UK firms in this tailend of the pandemic it'll be in other areas of virus detection.

They were practising their interpretative dance for Science Day, the Death Spiral.

Too many coffees?

It's visible on my Android phone but is absent on my Windows laptop. Odd. Still it IS a beta website.

Muck, perhaps th eexisting text was another part of the same thing:

"Qualified researchers may request access to individual patient-level data through clincialtrials@avacta.com" would satisfy clinicians' need to have an understanding of safety and efficacy. Such requests would be a bit of a resource overhead for Avcacta though I should think timewise and would depend on how much drug is available.

A very interesting and highly significant find indeed Muck. The content quoted in my earlier post is also there in the beta website (I'm more awake now!) so this IS new. I don't know why it's not on the active website - maybe it hasn't been updated yet or it doesn't have the facility to carry this information. The latter I suspect.

Highly unusual for expanded access to be offered before a first-in-human Phase 1a trial has officially completed I should think - much more likely to be offered in a drug's later efficacy-studying phases. This is all on Avacta's responsibility - not approved or recommended by any regulatory body - in collaboration with the patients' clinicians:

https://www.fda.gov/news-events/public-health-focus/expanded-access

To offer expanded access shouts that AVA6000 is not only safe and tolerable, but that it also works as a treatment - i.e. it is EFFICACIOUS.

Only a matter of days now until the news is announced to an unsuspecting world!

The old/current (non-beta) website has this:

"Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD:
No
Plan Description:
Qualified researchers may request access to individual patient-level data through clincialtrials@avacta.com"

Could be the same thing?

Why? - Unresolved insecurities

Yes, it was a multilevel comment...

Good news indeed! So pleased for you both