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Yeah, that didn't really make sense to me.

"...platform has the potential to significantly improve the safety and tolerability of chemotherapies, and other drugs, by targeting their release to the tumour.”

Maybe there is a case for targetting non-chemo drugs to the tumour, IDK.
Targetting other drugs to other targets that have upregulated FAP I can understand (arthritis for instance), but it doesn't seem to be saying that.

I agree MrR. Four cohorts with 'remarkably consistent' data should allow them to predict future data from increased doses, with the proviso that there is no tipping point/cliff edge that they know about or suspect or fear. They know their job; I'm sure they'll select an appropriate, if cautionary dose. Would be great though if we could move swiftly up the dosage levels.

...might be interesting to follow today. If up relative to sector movement with no significant PNT news announced then Avacta's news will have registered. If no change then Avacta is still currently below the radar over there or, more likely, link with Avacta isn't widely known. Of course, it'll probably go down!

What does our resident chartist say? The silence is deafening. Here. At the moment it is all about EVE.

Target 150 SZ? ;0)

Ronnycant, how would you reconcile your thought with "very significant reduction in the usual toxicities, plus the observed release of doxorubicin at significant levels in the tumour tissue, show that the pre|CISIONTM platform has the potential to significantly improve the safety and tolerability of chemotherapies, and other drugs, by targeting their release to the tumour."?

Have to agree with JRDC. Shares being transferred from greedy to sticky hands. For the real money, this is a longterm hold as we follow progress of chemo without side effects coming to patients in need..

I've just emailed the BBC World Service's World Business Report

world.business@bbc.co.uk

Let's bombard them with this news!

Avacta continue to use this 2016 market research report:
"Doxorubicin Market Size is Expected to Reach $1.38 Billion by 2024"
https://www.prnewswire.com/news-releases/doxorubicin-market-size-is-expected-to-reach-138-billion-by-2024-grand-view-research-inc-602613665.html

Howevber, this 2022 market research report:
"Doxorubicin Market Revenue to Cross $1,983.40 million by 2028 to Rise at a Stellar CAGR of 6.1% by 2028" says the market size was already $1.39 Billion in 2022
https://www.globenewswire.com/en/news-release/2022/07/12/2478328/0/en/Doxorubicin-Market-Revenue-to-Cross-1-983-40-million-by-2028-to-Rise-at-a-Stellar-CAGR-of-6-1-by-2028-Exclusive-Research-by-The-Insight-Partners.html

?

Opening price at least 150 SZ - your target for a quick profit. lol

I was kind of hoping there would be a further DE or few, but in parallel with Phase Ib starting, just to see how far this could be pushed and to provide greater flexibility in dosing. But to continue the DEs without starting Phase Ib means they want to obliterate tumours, and believe they can with muiltiples of th estandard doxorubicin dose.

Bl**dy F'in FANTASTIC!!!!!!!!!!!!

All will be revealed in the fullness of time...

I see a lot of scientific papers about the use of Affimer® technology in pharmacology but I don't see any agreements with major pharma companies, or any agreements other than the one with LG Chem (a small part of LG Chem, a major global chemicals company) and Daewoong Pharmaceuticals. Why is that?

Because they are employee share schemes... What I don't know is what level of employee each refer to...

Note the content of these three RNSes.

28 April 2022 - Block listing
EMI Scheme - 750,000 shares
LTIP Scheme - 1,250,000 shares

28 October 2022 - Block Listing Six Monthly Return
EMI scheme - 290,500 issued/allotted, 459,500 balance remaining
LTIP scheme - 790,813 issued/allotted, 459,187 balance remaining

16 January 2023 - Block listing
EMI Scheme - 800,000 shares
LTIP/ESOS Scheme - 2,200,000 shares

This to me very strongly suggests that the 459-thousand or so balances from October are very close to being taken up by Avacta employees and the LTIP, and now also ESOS schemes, need to be seriously topped up.

100% very positive news.

Can anyone say what these EMI and LTIP/ESOS schemes are wrt top management, middle management and grunts?

How on earth did a nine word bit of nonsense by a spike chaser who hasn't got a clue about what Avacta does get 18 recs????

Lucky those who can exploit this naive enthusiasm. The twitterampati for example.

"But i"... Don't leave us in the lurch Timski!

It hasn't really picked up upon, but pre|CISION™ prodrugs aren't limited to the off-patent anticancer standards that Avacta has announced that they have synthesised. Also included within a possible licenseing deal are any patent-protected best sellers if they have the amenable -NH2 in their chemical structure.

PLEASE LSE!!!!!!!!!!!!!!!! Give us the facility to filter threads started by those we've filtered..................

Toatie, please tell me the secret of starting a new thread with every post. And also why you do it.