Safe gamble Tyk2 trial in Covid15 Jul 2021 18:43
Just a refresh and for anyone whos very new:
Target genes
"Having highlighted the genes, the team were then able to predict the effect of drug treatments on patients, because some genetic variants respond in a similar way to particular drugs.
For example, they showed that a reduction in the activity of the TYK2 gene protects against Covid-19. A class of anti-inflammatory drugs called JAK inhibitors, which includes the drug baricitinib, produces this effect."
"This is a stunning realisation of the promise of human genetics to help understand critical illness. Just like in sepsis and influenza, in Covid-19, damage to the lungs is caused by our own immune system, rather than the virus itself. Our genetic results provide a roadmap through the complexity of immune signals, showing the route to key drug targets."
Dr Kenneth Baillie
Chief investigator and Academic Consultant in Critical Care Medicine and Senior Research Fellow at University of Edinburgh’s Roslin Institute
Our results immediately highlight which drugs should be at the top of the list for clinical testing. We can only test a few drugs at a time, so making the right choices will save thousands of lives. This work is only possible because of the generous contribution of the patients themselves and their families, research teams in NHS hospitals across the country, and the generous funding we’ve received from the public and organisations.
Worth noting the chief investigators involvement in the Recovery Trails program.
If he's highlighted that Tyk2 drugs should be top of the list, whos going to argue with him???
Apart from Trimme and his buddies!
https://www.ed.ac.uk/news/2020/genes-could-be-key-to-new-covid-19-treatments
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