Time to make some big decisions.12 Dec 2025 07:34
1/2
Perhaps a fair chance of some operational updates following securing the second tranche bonds, although that could be mitigated depending on what form the advanced negotiations are currently taking, and if we consider offers worthy of the existing scope of the bexmarilimab proposition.
Contrary to my own and others wanting of a monster takeover now, I think we should be singing from the roof tops about all our upcoming exciting clinical programmes ie combination trials with PD-1’s / chemo such as the melanoma, NSCLC, BC & STS trials, in light of the recent data presented at ASH
In my view, we must be willing to take this forwards ourselves if we do not see a Forty Seven style valuation. Our data is now more efficacious, more broad, has much greater longitudinal strength, and with a sublime safety profile, across both Bexmab & Matins, whilst treating the underlying aspects of disease, resulting in MRD negativity, Stem cell transplants and transfusion independence- that’s a serious differentiator and the holy grail compared to anything coming before it.
Following the appointment of Dekkers, and securing the second tranche bond, we are now in a superb position to raise funding at a significant premium to the current stock price & perhaps make the CLN entirely redundant, if the CFO sees fit, or to accompany the second tranche loan.
Furthermore, if we factor in inflation, a Forty Seven style valuation then, is worth around $6.5bn today, and bear in mind it is now irrefutably safer & more efficacious than Magrolimab was then, and easily arguably, at a more advanced point in its development and of higher calibre than Forty Seven was viewed as, in 2020.
I think to secure that mega valuation we should be firm about our intentions to take this forwards ourselves given the strong hand we have following the praise and recognition received from Bex data at all relevant major healthcare conferences, particularly the recent ASH data which I think has been overlooked and was a seminal moment for the company and Bexmarilimab, highlighting what we have here and how it can be utilised in even the toughest indications previously untouchable via an immuno oncology therapeutic.
So I know one in the hand can be worth two in the bush, but the one in the hand has to be a spectacular offer for the whole company, or it should involve us retaining a large share of the monster upside across other myeloid malignancies and solid tumours alike, if we are to go down the partnering route.
My view is the likes of Gilead and Merck will now be all over this company, and want the whole cake; and thus will be making their moves accordingly, that is to ensure a full takeover offer is more in SH’s interests than a smaller deal, cornering Juho and the board into selling out entirely.