Member Info for Basser1

ndr50 - Covid 19 and respiratory?

The Heme malignancies which look like they are first in line for trials include the option for SRA 515 and SRA 737 to work in combination. Correct me if I am wrong.

Londonville - the brokers comments on the Sierra pipeline are in line with what is shown on the Sierra website under the Science section.ie

1. SRA 515 momotherapy. Heme malignancies
and/or ( Blood and Bone marrow Cancers). Finalising Design
SRA515/SRA737

2. SRA515 Momotherapy. Solid Tumors in. Finalising Design
and/or Combination with SOC
SRA515 and SRA737

3. SRA 737 Gemcitabane. Solid Tumors. Finalising Design

Opportunities currently under consideration include co-operative trials.

Think we will here more news on these in the next couple of months.

Sierra daily share volume is 400% above average and its only midday across the pond. Might augur well for an update on Monday that involves much more than just Momelotinib. Dilley is presenting at 7.00am Eastern time so that will be around midday here. Fingers crossed.

Aber - agree totally.

I have sent an imaginary message to Warren Buffet. He tells you all to STFU and sit and wait. That’s the only way you will have a happy new year! Heed the message or depart in despair.

DP it’s just another antiviral pill not a TYK2 immune system inhibitior like SDC1801. As we know anti virals can encourage variants in the longer term. The immune system has to be the target for longevity as suggested by Nature and the WHO.

https://www.investegate.co.uk/peel-hunt-limited/rns/placing-and-proposed-admission-to-trading-on-aim/202109240700068810M/

Peel Hunt only applied for Aim in late September2021. Some interesting snippets. Quote ‘it’s award winning research is provided to over 1,200 institutions. Let’s hope they are now working to get the Sareum story out ASAP.!

Workingpharma - maybe it was the HNWIs who pushed Peel Hunt to take Sareum on. If so they are very influential. Don’ t for any reason see why PH would take on Sareum without thorough research first .

Nice positive post Silverfoil. Beats being stressed out because the share has gone down o.2p. We are very lucky to be able to look forward to exciting times in 2022. Not many opportunities like this come along in a lifetime. Relax, sit back and watch it all unfold over the coming months. Exciting times indeed.

The market is ignorant of the developing science. Most investors do not bother to read the science. If they did they would come to realise this would probably be one of the bargains of the Century. TYK2 gene over-expression is the cause of autoimmune diseases, Cancers, Sepsis and virus vulnerability due to over-reaction of the immune system. And Sareum has two TYK2 inhibitors to address these conditions. Everyone clear?

Skyrider/ Thoth - thanks for the info. Clearly something we all need to be aware of.

Sky rider - what do you mean by a high percentage. What is the actual figure?

More evidence that combo of SRA737 and Adoversitib reduces tumour growth in ovarian and breast cancer solid tumours with a TP53 mutation. As John Reader said in RNS some time ago, TP53 gene mutation occurs in up to 50% of all solid tumours. The future is very bright indeed.

Thanks Montyboz - just checked what cyclin E Amplification means. It is an over expression of Cyclin E which is associated with poor survival rates.

Nice find Citizen. Well Written Paper easy for the layman to understand the science. If Krone is around might be worth posting on Sierra Stocktwits?

Be happy, It’s the Winter Solstice today and we go forward to a new Dawn and bright sunny uplands. 2022 is going to be a very special year for Sareum PLC and its shareholders.

Read an article in the I newspaper today re reluctance of professional footballers to have vaccinations. They are being warned that non vaccination shows a greater risk of heart inflammation when infected with Covid 19 and that can result in ongoing problems post covid. It’s inflammation that causes most post Covid problems resulting from the immune system being thrown out of kilter. Can see a major role for SDC1801 in front line And post covid treatments.

Some big companies with stock in pence eg Lloyds Bank currently 46p.

1 new share for 10 is the maximum for me. Anything higher and I will vote “no”.