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Pin to quick picksN4 Pharma Plc Share News (N4P)

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N4 Pharma reassures shareholders over future of 'Nuvec'

Mon, 15th Apr 2019 15:33

(Sharecast News) - Specialist pharmaceutical company N4 Pharma updated the market on the development of 'Nuvec' on Monday, following the disclosure of inconsistencies in the efficacy of Nuvec between various in vitro and in vivo studies.The AIM-traded firm said the update came in light of a subsequent data review to determine appropriate next experiments, the aims of which were to resolve the inconsistencies and demonstrate repeatable in vivo data.It said that, in reviewing the work done by collaborators and contract research organisations engaged by the company, it had become "clear" that not only were there a number of variables between the studies such as dosage, injection volume and source of antigen, but also the handling and preparation of Nuvec may have differed "materially" from the original protocols used by the University of Queensland (UQ) and developed by N4 Pharma.With Nuvec originating out of UQ and the original in vivo success having been achieved there, the directors said they had decided that - in order to maximise the chances of success for future or repeat studies - the original data transfer reflecting UQ's successes needed to be more clearly documented.That would assist collaborators and contract research organisations with their subsequent work.To that end, the company said it would commission UQ to repeat its original studies to demonstrate repeated strong antibody response with the standard test antigen 'Ovalbumin' and, in doing so, document "clearly" the preparation steps for Nuvec prior to injection.In addition, N4 Pharma said it would expand the study to include further variables to strengthen the depth of data to emerge from this work.The study at UQ was expected to then provide a validated testbed against which future enhancements could be benchmarked.It was expected that once that work commenced, it would take between three and four months to conclude and for the results to be documented.In the meantime, the directors said they were "actively reviewing" all other work streams to put on hold any other non-essential studies not already started."In reviewing our various data sets and talking to our partners, it has become clear that the most expeditious route to progressing Nuvec is to revert to source and the work of UQ," said chief executive officer Nigel Theobald."The team at UQ know Nuvec better than anyone and we feel confident that a positive repeat study, clearly documented with respect to methodology, will greatly aid other contract research organisations in their studies."Whist it is a disappointing decision to put other work on hold, doing so keeps the company well funded to do our future planned work once we have a better documented handling and preparation protocol from UQ."
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24 Mar 2020 15:49

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25 Feb 2020 11:42

N4 Pharma Annual Loss Narrows Amid Work To Improve Nuvec System

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25 Feb 2020 08:49

N4 Pharma narrows loss as it continues development work

(Sharecast News) - Specialist pharmaceutical company N4 Pharma reported a smaller operating loss for 2019 on Tuesday, at ?0.95m, compared to ?1.42m in the prior year.

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11 Feb 2020 14:19

N4 Pharma shares rise on partnership with Nanomerics

(Sharecast News) - Specialist pharmaceutical company N4 Pharma has signed a 14-month research collaboration with Nanomerics to produce and test two candidate formulations using its 'Nuvec' delivery system, it announced on Tuesday.

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11 Feb 2020 11:37

N4 Pharma Signs Research Collaboration Agreement With Nanomerics

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18 Sep 2019 12:04

N4 Pharma Interim Loss Widens After Non-Repeat Of Grant, Disposal Gain

(Alliance News) - N4 Pharma PLC on Wednesday said its loss widened slightly in the first half of the year, owing to grant income and a gain on an investment sale the year before which did not in a

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20 Aug 2019 11:49

N4 Pharma Repeats Study And Finds Nuvec Successful At "Certain Doses"

(Alliance News) - N4 Pharma PLC on Tuesday said it has repeated the in-vivo study of Nuvec and shown it does work "when using multiple injections at certain doses".Shares in N4 at

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19 Jun 2019 13:38

N4 Pharma To Start Experiments On Nuvec; Results Due In Two Months

(Alliance News) - N4 Pharma PLC on Wednesday said it will begin experiments on its Nuvec system on Friday this week with results due in around two months.Shares in N4 were up 20% at 4.30 in

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12 Jun 2019 16:04

UK Shareholder Meetings Calendar - Next 7 Days

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21 May 2019 13:25

N4 Pharma Appoints John Chiplin as Non-Executive Chairman

LONDON (Alliance News) - N4 Pharma PLC on Tuesday said it appointed John Chiplin as non-executive chair of the company with immediate effect.Furthermore, the pharmaceutical firm appointed a

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14 May 2019 12:09

N4 Pharma Loss Narrowed By Cost; Will Explore Assets Outside Nuvec

LONDON (Alliance News) - N4 Pharma PLC on Tuesday reported a narrowed loss for 2018 on lower costs and said it is exploring new opportunities while continuing work on core Nuvec drug delivery in -

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15 Apr 2019 15:20

N4 Pharma Finds Issues With In Vivo Nuvec Testing And Plans Repeat

LONDON (Alliance News) - N4 Pharma PLC on Monday said it has become aware of a number of issues with the in vivo studies of its Nuvec delivery system.On Tuesday last week, N4 announced of a

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9 Apr 2019 11:27

N4 Pharma Shares Sink As Nuvec Fails To Produce Response In-Vivo

LONDON (Alliance News) - N4 Pharma PLC on Tuesday said early in-vivo tests of its Nuvec delivery system did not match positive results from in-vitro tests, causing shares to slump.Shares in

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