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N4 Pharma bears more good news on its Nuvec particles

Wed, 28th Nov 2018 11:30

(Sharecast News) - Specialist pharmaceutical company N4 Pharma updated on the latest key research findings for its 'Nuvec' delivery system on Wednesday.The AIM-traded firm had announced on 29 October that research undertaken to then indicated that Nuvec particles themselves had demonstrated a "clear adjuvant effect" to help deliver a level of immune response for both messenger RNA (mRNA) and plasmid DNA (pDNA) , encoded with the standard test antigen Ovalbumin (OVA).It said on Wednesday taht it had now undertaken further analysis of its pDNA OVA findings, and demonstrated that the immune response observed was sufficient to have produced strong levels of antibodies specific for OVA.A strong level of antibody production was essential for a vaccine to deliver immunity, N4 Pharma explained.It said the levels of antibodies produced were greater than those of in 'vivo-jetPEI', an industry standard used to deliver pDNA-OVA in pre clinical studies.Additionally, it said that assessing the detailed classes of antibodies produced showed that Nuvec delivered a "strong, robust level" of the specific antibodies needed for effective oncology and virology vaccines.The company had also now manufactured one new large batch of particles for its EUNCL and Adelaide research work, it explained, and would be shipping particles from that batch to the relevant parties shortly.N4 Pharma said the research for those programmed would now commence fully in January.EUNCL was expected to deliver results towards the end of the third quarter of 2019, with the first part of the Adelaide work to take four weeks and start in the new year, with results expected during the first quarter."These results are once again another positive step forward for our Nuvec delivery platform," said chief executive officer Nigel Theobald."The data now shows Nuvec® is capable of producing specific and relevant strong levels of antibodies required for the development of vaccines and cancer treatments."Theobald said the company would continue to provide updates as it added to its "already encouraging" data package to aid its commercial collaboration discussions."The production of a robust data package using the test antigen Ovalbumin provides compelling evidence of the potential for Nuvec to be an effective delivery system for a potential partner's specific DNA or RNA antigen."
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27 Mar 2023 15:50

UK earnings, trading statements calendar - next 7 days

Tuesday 28 March 
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Wednesday 29 March 
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Thursday 30 March 
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Friday 31 March 
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Monday 3 April 
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9 Mar 2023 14:32

EARNINGS SUMMARY: Franchise Brands blooms; Tlou Energy loss widens

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17 Jan 2023 16:23

TRADING UPDATES: hVIVO wins contract; Dev Clever cancels shares

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18 Nov 2022 11:16

AIM WINNERS & LOSERS: Parsley Box to exit AIM as shares wilt since IPO

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18 Nov 2022 11:02

N4 Pharma plummets on broker offer to raise up to GBP1 million

(Alliance News) - N4 Pharma PLC shares plummeted on Friday, after it raised GBP1.0 million through a placing of 50.0 million shares and announced a broker offer to raise up to GBP1.0 million.

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18 Nov 2022 08:11

N4 Pharma shares tumble following placing, broker offer announcement

(Sharecast News) - Shares in pharmaceutical company N4 Pharma tumbled on Friday after the group said it had raised £1.0m via the placing of 50.0m new ordinary shares of 0.4p each and detailed a broker offer aimed at raising as much as another £1.0m.

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1 Nov 2022 17:06

IN BRIEF: N4 Pharma expands patent application claims for Nuvec

N4 Pharma PLC - Derby, England-based pharmaceutical company focused on developing Nuvec, a delivery system for vaccines and cancer treatments - Provides a patent application update for Nuvec.

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4 Oct 2022 13:32

N4 Pharma reports success in recent 'Nuvec' testing

(Sharecast News) - Specialist pharmaceutical company N4 Pharma announced success in its in-vitro testing of its 'Nuvec' drug delivery system on Tuesday, loaded with two small interfering RNA (siRNA) probes.

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4 Oct 2022 11:19

AIM WINNERS & LOSERS: N4's Nuvec success; Watkin Jones tumbles

(Alliance News) - The following stocks are the leading risers and fallers on AIM in London on Tuesday.

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4 Oct 2022 10:38

N4 Pharma announces successful test in next stage of Nuvec development

(Alliance News) - N4 Pharma PLC on Tuesday announced successful in vitro testing of Nuvec when loaded with two small interfering siRNA probes.

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4 Oct 2022 08:46

LONDON MARKET OPEN: Stocks rise as market sentiment recovers

(Alliance News) - Stock prices in London opened sharply higher on Tuesday, lifted by more positive market sentiment following the UK government's tax U-turn, as well as some positive trading updates.

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29 Sep 2022 15:09

EARNINGS UPDATES: Crestchic raises outlook on record year-to-date

(Alliance News) - The following is a round-up of updates by London-listed companies, issued on Thursday and not separately reported by Alliance News:

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29 Sep 2022 12:11

N4 Pharma reduces losses as Nuvec development continues

(Sharecast News) - Specialist pharmaceutical company N4 Pharma reduced its operating loss in the first half, it reported on Thursday, to £0.75m from £0.97m a year earlier.

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14 Sep 2022 12:03

IN BRIEF: N4 completes testing on loading Nuvec drug with siRNA probes

N4 Pharma PLC - Derbyshire, England-based pharmaceutical company - Completes initial testing on loading its Nuvec treatment with two generic siRNA probes at the same time. siRNA can prevent cells from communicating, potentially preventing cancer cells from replicating. N4 are now undertaking experiments using siRNA sequences against known oncology targets. This includes in vitro using a lung cancer cell line and, after that, in vivo studies in mice. Chief Executive Officer Nigel Theobald said: "We have now identified a very strong commercial point of difference for Nuvec in that it can be successfully loaded with at least two siRNA genes".

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