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Seems like we need to strike up a partnership with AgentB Pharmaceuticals
Thought this was interesting;
https://www.express.co.uk/life-style/health/1320424/Coronavirus-cure-vaccine-breakthrough-latest-found
More detail here - https://www.news-medical.net/news/20200809/Cutting-edge-synthetic-peptides-block-SARS-CoV-2-(COVID-19).aspx
I’m no scientist but there does seem to be a lot of similarity between the way this synthetic tech neutralises the virus, and the way Affimers have been shown to do so. Happy to be told otherwise by those more in the know!
Notable that the Daily Express article suggests it could be delivered by nasal spray.
And mouthwash
https://www.dailymail.co.uk/news/article-8611685/Iodine-mouthwash-protect-against-Covid-19.html
Nasal admin of interferon discussed on the other board too.
Captain Stanley, I agree it isn't very clear the method of delivery,
Affimer® technology is a novel class of biotherapeutic based on a naturally occurring human protein called Stefin A.
Affimer® proteins are rapidly cleared from the body if not engaged with their target. The PK/PD of therapeutic Affimers can be tuned using Affimer® XT, a serum albumin binding Affimer half-life extension platform, or using Affimer-Fc fusions. Other Affimer® based half-life extension technologies, such as hyaluronic acid binding Affimer® proteins, are in development.
Peptides represent a billion-dollar market in the pharmaceutical industry, but they can generally only be taken as injections to avoid degradation by stomach enzymes. Scientists have now developed a method to generate peptides that resist enzymatic degradation and can be taken orally.
Sub cut injections, IV. Best guess tbh. There is nothing to say it can/cannot be administered through a nebulizer, but there is no need for it to be. Sng has the benefit of being directly administered to the site as sub cut or iv, there are more side effects. Tils also are doing direct to lungs but going through saftey and efficency trials. Please correct me if my understanding is wrong, I am not in the field tbh.
AgentB for a 100!
Thanks to all for a fascinating discussion. As someone whose peak scientific achievement is a biology ‘‘O’ level, I feel honoured that my idea was taken seriously and may indeed have some merit!
May I not maybe
AgentB maybe be the first to apologise
https://www.sciencemag.org/news/2020/07/can-boosting-interferons-body-s-frontline-virus-fighters-beat-covid-19
And in an early, unrandomized preventive trial in a hospital in China’s Hubei province, none of 2415 medical workers who took daily interferon nose drops got the virus,
Lots of people have mad ideas. They laughed when Louis Armstrong said he would fly to the moon.
Some investments wins in this list
https://laegemiddelstyrelsen.dk/da/nyheder/temaer/ny-coronavirus-covid-19/~/media/5B83D25935DF43A38FF823E24604AC36.ashx&ved=2ahUKEwjGvOy7mIvrAhUpRhUIHZqPCggQFjAKegQIBBAB&usg=AOvVaw0wUmws_hnUNtvB1IVpc4np
Let's just stick to what avct have in the current pipeline, we know these majic affirmers do their stuff well without confusing matters. Should be a good few weeks ahead.
The most successful treatment so far is Synairgen's IFN-ß for the treatment of COVID-19
Interferon beta (IFN-beta) is inhaled so perhaps it's not such a crazy suggestion after all....
OK I've run with this idea and my new timeline (version 28) now includes nasal administration - just trying to optimise it and will update investors at some time in the future. We decided against nebulization as you can see
https://cdn.instructables.com/ORIG/FTT/C00C/F6B7Q2KD/FTTC00CF6B7Q2KD.jpg?auto=webp&frame=1&width=320&md=1189442381
Aur y byd na'l berlau man
Nid wy'n gofyn bywyd moethus,
Insert big yellow thinky head
People kick off at fluoride in their drinking water, never mind affirmers in our air con.
Tecach yw na'r lili dlos:
yn llawn daioni,
You will be singing Calon Lan next
Just love the tag mate
All those Zulus coming down on the small defenseless er Fort - Bastion etc
Wader you want from me
RD,
Great to see that your post of the day was not your swansong on here.
Good weekend all
LOL.