Sphere Medical Holding Regulatory News (SPHR)

For Immediate Release 11 August 2014

Sphere Medical Holding plc

("Sphere Medical" or the "Company")

Professor Jean-Louis Vincent joins Medical Advisory Board

~ Appointment of World Authority on Critical Care Medicine ~

Cambridge, UK, 11 August 2014: Sphere Medical Holding plc (AIM: SPHR.L), a leading developer of innovative monitoring and diagnostic products for the critical care setting, today announces the appointment of Professor Jean-Louis Vincent to its Medical Advisory Board (MAB).

Jean-Louis Vincent is Professor of Intensive Care at the Université Libre de Bruxelles and the Head of the Department of Intensive Care, Erasme University Hospital (University of Brussels). Professor Vincent is a world authority on intensive care medicines and is President of the World Federation of Societies of Intensive and Critical Care Medicine and a member of the editorial board of approximately 30 international journals on intensive and critical care.

Professor Vincent will work alongside other Sphere MAB members including Dr Tom Clutton-Brock, Head of Anaesthesia & Intensive Care at The University of Birmingham Medical School and Associate Medical Director at the University Hospital Birmingham NHS Foundation Trust.

Commenting on this appointment, Sphere Medical's Chief Executive Officer, Wolfgang Rencken, said: "Professor Vincent's appointment to the Medical Advisory Board is strong validation of the potential of Proxima, our patient-attached arterial blood gas analyser. His significant experience in the critical care setting makes him an invaluable addition to the team at this pivotal time as we plan for the launch of Proxima later this year."

Professor Vincent added: "Proxima has the potential to bring about a paradigm shift in the intensive and critical care setting. I look forward to working closely with the MAB and contributing to Proxima's future success following its commercial launch in the near future."

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Notes for Editors

Sphere Medical (AIM: SPHR.L), is a medical device company developing a range of innovative monitoring and diagnostic devices designed to significantly improve patient care.

Sphere Medical's products deliver real time analysis of blood gases, electrolytes and drug levels with laboratory accuracy, at the patient's bedside. Sphere Medical's products can be used in a wide range of medical applications, enabling faster clinical decision making and improved patient outcomes, whilst reducing costs for healthcare payers.

Sphere Medical entered into a collaboration agreement with Ortho-Clinical Diagnostics, Inc. for the development of Proxima and enhancement of Sphere's operational and production capabilities in 2013.

Sphere Medical has a number of partnerships with industry leading medical device companies and has received a strategic investment from Ortho Clinical Diagnostics (now part of Carlyle Group). Other significant investors include Life Sciences Partners (LSP Life Sciences Fund).

For further information, please visit www.spheremedical.com