Proteome Regulatory News (PRM)

21 Mar 2007 07:00

Proteome Sciences Plc ("the Company") Notifiable Interest

A form TR-1 containing the following information has been received by the Company.

TR-1 notification of major interests in shares

1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached:

Proteome Sciences Plc

2. Reason for the notification

An acquisition or disposal of voting rights

3. Full name of person(s) subject to the notification obligation:

Credit Agricole Cheuvreux International Ltd

4. Full name of shareholder(s) (if different from 3):

5. Date of the transaction (and date on which the threshold is crossed or reached if different):

15 March 2007

6. Date on which issuer notified:

19 March 2007 (by fax & post)

7. Threshold(s) that is/are crossed or reached:

7%

8. Notified details:

A: Voting rights attached to shares

Class/type Situation previous Resulting situation after the triggering of shares to Triggering transaction transaction if possible Notification required under DTR transitional using ISIN provision 7 CODE Number of Number of Number of Number of voting % of voting Shares Voting shares rights rights Rights Direct Direct Indirect Direct Indirect Ordinary 9,134,552 9,134,552 9,234,552 9,234,552 N/A 7.02% N/A shares GB0003104196 B: Financial InstrumentsResulting situation after the triggering transaction Type of Expiration Exercise/ Number of voting % of voting financial date Conversion rights that may rights instrument Period/ Date be acquired if the instrument is exercised/ converted NIL Total (A+B)Number of voting rights % of voting rights 9,234,552 7.02%

9. Chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held, if applicable:

SAS Rue La BoetieCredit Agricole SACalyon SA

Credit Agricole Cheuvreux SA 9,234,552 7,02%

10. Name of the Proxy holder:

N/A

11. Number of voting rights proxy holder will cease to hold:

N/A

12. Date on which proxy holder will cease to hold voting rights:

N/A13. Additional information:N/A14. Contact name:

Christopher Pearce or James Malthouse 01932 865065

Proteome Sciences PLCThilo Hoffmann 020 7426 9000Teather & Greenwood Limited15. Contact telephone number: