Astrazeneca Regulatory News (AZN)

Transaction by Persons Discharging Managerial Responsibilities

Disclosure Rule DTR 3.1.4

On 27 March 2015, the individuals listed below, who are all persons discharging managerial responsibilities, were granted awards over the Company's ordinary shares or American Depositary Shares (ADSs) under the terms of the AstraZeneca Deferred Bonus Plan (AZDBP), the AstraZeneca Performance Share Plan (AZPSP) and the AstraZeneca Investment Plan (AZIP). One ADS equals one ordinary share.

The AZDBP award represents the portion of each individual's annual bonus for 2014 that they are required to defer into shares. The shares are subject to a three-year holding period (27 March 2015 to 26 March 2018).

The AZPSP award is subject to a combination of performance measures focused on our scientific, commercial and financial performance assessed over a three-year performance period (1 January 2015 to 31 December 2017). The award will vest on the third anniversary of the date on which it was granted, except for awards to Executive Directors, which will be subject to a further two-year holding period before the award vests.

The AZIP award is subject to two performance hurdles relating to dividend and dividend cover; both must be achieved in each year of the four-year performance period (1 January 2015 to 31 December 2018) for the award to vest. The award is subject to a four-year holding period, commencing at the end of the performance period.

Details of the performance measures that relate to the AZPSP and AZIP awards are available on the Company's website at www.astrazeneca.com/Investors/Annual-reports.

On 30 March 2015, the interest of Dr Briggs Morrison, a person discharging managerial responsibilities, in the American Depositary Shares (ADSs) of AstraZeneca PLC changed as detailed below. One ADS equals one ordinary share.

The change in interest relates to the vesting of awards of shares made in March 2012 under the AstraZeneca Performance Share Plan and the AstraZeneca Restricted Share Plan as set out in the table below.

In respect of the award of shares under the AstraZeneca Performance Share Plan, following the application of performance measures specified at the time of grant, Dr Morrison has become beneficially entitled to 50% of the shares originally awarded. In accordance with the plan rules, any unvested part of the award has immediately and irrevocably lapsed.

In respect of the award of shares under the AstraZeneca Restricted Share Plan, in accordance with the terms of the award, Dr Morrison has become beneficially entitled to all of the shares originally awarded.

Sufficient vested shares have been withheld to cover certain tax obligations arising on the vesting and the net number of shares has been delivered into a personal brokerage account.

For tax purposes, the fair market value of the shares at vest was $70.07 per share being the closing price of AstraZeneca ADSs on the last trading day preceding the vesting day.

A C N Kemp

Company Secretary

30 March 2015