Member Info for Wiggly

The unknown, unknown unknowns of course.

Its just my view though... you dont see many stocks rising like this with serious strength continuing. Typically this type of rise is driven by insiders.

Right now is a time where is should have already cooled off, the fact it hasn't is a wonderful sign of strength.

Agree with this. The strength is unbelievable. It confirms in my view that there is info that is not yet in the public domain. We have buyers accumulating who are uninterested in the technical status

Safety committee just concluded their Friday meeting?

DE approved?

Shorts closing?

License deal reached?????

Seems we have lift off!

Trading pot in...sorry out...in...out..in

Oh dear..

Ophidian,

It seems obvious to me that you sold your 'trading pot' on April 8th at 96 (a little early as you stated)..

Since then you've littered the Chat talking about waves and retraces. I suppose it makes a nice change from your usual rumours and timelines.

Strength of the bid! Gonna blow

Looks ready to blow!

DE + Trial progression (8 months and counting with no patient showing disease progression)) are sufficient for me to have strong belief that we have a working Precision platform but, for those that need more, simple refer to the post from Energy below....

Why present to AACR if it’s not working.
If it’s not working.

Why take biopsies if not needed in phase 1a
If it’s not working.

Why keep adding to the board of directors with world class oncology experts with 20 million left in the bank.
If it’s not working.

Why start recruiting in Glasgow with Sheffield and Newcastle also getting ready to recruit patients.
If it’s not working.

Why extend to two trial sites in USA.
If it’s not working.

Why DE and inform shareholders 2 x more DE by the end of 1b
If it’s not working.

Why is Point Bio with a licence to use precision very close to its ATH SP.
If it’s not working.

Why select precision’s next drug 3996.
If it’s not working.

Why move therapeutics laboratories just 60 miles from Cambridge to London
If it’s not working.

Why 8 months into trial with a safety committee meeting every two weeks and Avacta board members keep repeating Remarkably consistent data would the trial keep going.
If it’s not working.

Why spend 18 months developing a covid test and just as you receive Home Use Authorisation and have a second manufacturer complete TT with a world wide distribution partner in place ,then pull the test because it is not as sensitive on the latest variant. Which could damage the reputation of Avacta’s lead cancer trial AVA6000.
If it’s not working.

The trial has been running for 8 months and during this period multiple patients have been dosed on multiple occasions, some of which at dose levels greater than the standard of care.

We know based on the criteria for trial continuation that:

1. Ava6k has so far proved to be safer than Dox (see DE and continuation)
2. There has been no significant cancer progression (tumor increase / spread ) within the patient population.

Couple the 2 together and I believe that you now have proof of a working Precision platform.

It's only a matter of time before we see a major re-rate and I believe the recent rise in only just starting.

Timster,. We might be heading there. This is just the start.

The fact we did not have red day, even when the early morning dip encouraged it, really does suggest we have a real leak at play. Up 150% in one month and still we have a buyer driving the share price higher despite traders exiting. Exciting

I think we move at least 100% + between now and DE RNS.. (which is imminent )

150% up in 1 month and refusing to correct.... That tells me all I need to know about this rise

Strong start! Big pharma is buying imo.

If big pharma have some insight into the data to date (not yet released to the public) I think there is a real chance of a sustained rise to heights that will surprise many.

The amount that Takeda would be prepared to pay to cease the revenue decline will be huge.

How would they respond if another bidder were to appear?

Exciting few weeks ahead.

Block buyer very active today... Not long until tr1

Lilarch, I agree, there will be multiple interested buyers therefore If precision is proven the buy out price will be astronomical for the reasons you have stated.

Great Post.

Some additional 'whys'

Why are world class directors attracted to join Avacta 8 months into the trial?

If its not working.

Why did the the Chairman and CEO give the following statement 8 months into the trial 'We are VERY confident and excited about the immediate and long-term opportunities for the Group'

If its not working.

I think the last why (outlook guidance) is most telling. You cannot be VERY confident in something that is currently unknown or under question.

If there is no cancer, the concentration in the normal blood will not be high enough to activate 6000 (thankfully, that‘s the whole point!).

This poses an interesting question...which is.. could Ava6k be administered as a preventative medication (perhaps given at age xx in order to kill cancer cells at a very early stage)