SCLP's Interim Results Presentation Q & A26 Feb 2025 11:19
I received this email from the Co. this morning in response to my written questions that I submitted. Impressive to reply in such detail. Happy to share with LSE B.B.. Hope you find something of interest. Bit more to follow as won't all fit on one post.
Good morning, John,
Please find below responses to your questions submitted during Scancell’s Interim Results Presentation.
What has happened to Modi-1 treating TNBC & Ovarian cancer?
Data from patients receiving the Modi-1 cancer vaccine as a monotherapy showed that it was safe and well tolerated and demonstrated encouraging early efficacy in high grade serous ovarian carcinoma and triple negative breast cancer. The number of patients who have experienced long periods of stable disease following monotherapy with Modi-1 is encouraging. Based on this, it has been decided to evaluate Modi-1 in combination with checkpoint inhibitors, as first line therapy in advanced cancer.
Is there any interest beyond GlyMab?
Yes – we continue to see commercial traction around both our Glymabs® and AvidiMab® antibodies and are also having early conversations around the vaccines.
I think you earlier indicated in 2024 that you had active discussions 5 C0'c re: anti bodies. Is that still the case?
While we are unable to comment on specifics, active discussion with pharmaceutical and biotech companies are ongoing.
Are the Trials big enough to generate the level of interest we all hope for? They seem very small numbers. Are they considered statistically robust at these numbers?
The number of patients recruited into both the first stage of the Phase 2 SCOPE study and Phase 2a dose expansion ModiFY study fell within the parameters intended for these trials. Based on the positive results from the first stage of the SCOPE study, for instance, there was a greater than 90% probability that the second phase would also be successful, and we are incredibly excited about the exceptional data that has been reported from the first cohort investigating SCIB1. 43 patients have now been recruited into this cohort, which is due to report 25-week data in mid-2025, and further cohorts investigating next-generation vaccines iSCIB1+ and intradermal delivery continue strong recruitment, for a total of 43] patients.
We remain confident in the statistical robustness of our results.