Member Info for Toukankahmoon

Yorkshire

OK then why has P1a gone on for so much longer than we were originally told it would? If as some say it was because Al wasn’t allowed to increase the dose in bigger steps then it can’t really be seen as Al’s fault.

What else is he guilty of? Even though it is a safety trial he obviously thought that the data was good enough to attract funding and I presume he was let down at the last minute and had to secure funding at a rock bottom price to continue a much longer clinical trial. Again I don’t see this as his fault. In terms of the ambiguous communications, it’s his job to paint as good a picture as possible. It will be disastrous if he is forced out.

The post below gave me a ChatGPT analysis score of GENUINE 3

For once I agree with you - we don’t want change at the moment. I know Al hasn’t got total control over the clinical trials but I think he was far too slow in moving to a two week cycle when it was obvious that the target trial population was too broad. I think he believed that AVA6000 would perform well on lower FAP tumours and was caught off guard. Continuing to 7 rounds didn’t give him the results he needed to impress BP and he was forced into a fire sale fund raise.

All along he has been the king of ambiguous communications knowing that enough of us would read these in the most positive light.

If arm2 doesn’t yield the impressive results we need then Avacta might not get the opportunity to roll out what would’ve been a fantastic pipeline of life saving treatments.

Genstar

What have I said that runs contrary to the facts?

Bella

Have you owned shares before and been involved in voting?

You seem very naive

Ice

For once I agree with you - we don’t want change at the moment. I know Al hasn’t got total control over the clinical trials but I think he was far too slow in moving to a two week cycle when it was obvious that the target trial population was too broad. I think he believed that AVA6000 would perform well on lower FAP tumours and was caught off guard. Continuing to 7 rounds didn’t give him the results he needed to impress BP and he was forced into a fire sale fund raise.

All along he has been the king of ambiguous communications knowing that enough of us would read these in the most positive light.

If arm2 doesn’t yield the impressive results we need then Avacta might not get the opportunity to roll out what would’ve been a fantastic pipeline of life saving treatments.

Wynd

I’ve inherited a Hofner Club 60 though it was used by a friend in clubs around Merseyside in the 60s. It’s been retrofitted with Seymour Duncan pickups. Any idea what its worth?

Ice

I’m not after a row but you could have said the same thing anytime over the last few weeks and what has happened? It’s gone down. If you mean that by mid year it will be up again then I agree😄

Ice ffs stop the unfounded ramping. There is no new information to support a rise at this point other than how low the SP is at the moment

Jeez the management is so good they can’t even get a simple RNS right🤣

Watching

. . . and your considered opinion is what exactly?

Bella

Why do you persist in abusing anyone who doesn’t follow your Pom Pom waving delusion?

It isn’t a lie, it’s a fact. They have increased their short to 0.6 %.

It’s about time that the Pom Pom girls on here opened there eyes to facts rather than just ignoring them and posting wishful thinking based on f*ck all.

Timster posted;

“1. AVA6000 exhibited rapid distribution, with a half-life of 45 minutes backing up my assertion that dilution in the bloodstream is too rapid.

Comedy gold 😂😂😂😂😂”

Tim all you have shown here is that you haven’t bothered to read the article that started this thread off.

Watching

What is inaccurate about the fact I have quoted?

Ice

Yes of course I understand that and I wouldn’t be surprised if they move to a weekly dosing regime to keep the levels of AVA6000 as high as possible in order for as much as possible to be in bloodstream around TME. And of course it’s the precision of AVA6000 that enables this and why we are all here invested.

CTSFO

Yes if the rapid reduction in free AVA6000 is mainly due to it being cleaved in the TME then that is brilliant, but as I say based on the overall results including biopsies and what has happened to clinical trial design, then IMHO, it isn’t, it’s being excreted too quickly. Perhaps our metabolism and kidney function is far better in this respect than mice?

Dilution in terms of parts per million of AVA6000 versus blood. As uncleaved AVA6000 is excreted (or whatever the correct term is) from the body, the amount in the blood decreases. That’s what I mean by dilution. Therefore less available in TME to be cleaved.

Lovable

You are quoting dox half life. That is meaningless in my argument (other than ensuring that any cleaved dox that escapes from the TME is excreted quickly before it can do much harm to other organs). I was referring to the AVA6000 half life stated in the original article.

Oxygen

Right on and that’s why Al won’t do any deal that means he would lose control of his baby. Primarily he is in this because it’s his life’s work.

Tim

Thank god you’re still here. I was beginning to worry about you 😄

For me this is the clearest analysis of trial results. An excellent article but my takeaways are:

1. AVA6000 exhibited rapid distribution, with a half-life of 45 minutes backing up my assertion that dilution in the bloodstream is too rapid.

2. Tumor biopsy data demonstrated a mean concentration of doxorubicin in the TME of 860 ng/gm (range 76-2310 ng/gm, n=9). Which leads me to believe that there needs to be a lot of work done on targeting patients and dosing regime.

3. In contrast, blood samples collected at the biopsy showed a circulating free doxorubicin concentration of 8.3 ng/ml (range 2.4-15.9), indicating a higher concentration of doxorubicin in the tumor relative to plasma. Obviously supporting the conclusion that the platform works.

So we await the results analysis of arm2 to find out whether I’m selling my house to upsize or downsize 🤣🤣🤣. That’s a joke BTW.

Bella

Agree with all your points but we will only know when arm2 results are analysed