Reminder15 Dec 2021 00:00
The toolkit of therapies needed to manage Covid-19 infections is likely to contain a number of useful medications. Clinicians will have protocols as to when they should use them during the course of infection and where they have a material outcome of benefit to particular patients with ascribed symptoms. Synairgen is focusing on patients that are generally in need of hospitalisation or have arrived in the hospital setting and are breathless and requiring oxygen therapy support. So medications taken at earlier stages do not compete with the Synairgen cohort likely to be arriving at hospital. The hospitalisation cohort per day is currently around 1250 people in England which may have 40,000 known run rate of positive results. Adding the unknown tested per day to that 40,000 gives a population cohort size of a fraction of a percent, however it has an accumulative impact over time. The therapies tackling this cohort using passive therapy techniques such as Adagio monoclonal antibodies which again is injected into the blood stream (as opposed to Synairgen's immunomodulator that interactions with chemical receptors in surface lung tissue through a nebuliser), usually delivers worse outcomes for those patients requiring high flow oxygen therapy. A number of studies have shown the deficiencies of the different injected monoclonals that do not bind with receptors in the lung that impact on viral replication within that organ. Monoclonals antibody therapies have a place in the toolkit which is to aid the provision of immunity for those that are non-responders to vaccine therapies, waning immunity from previous vaccinations or may have been immunocompromised by other treatments for other diseases. Like Synairgen they will have their own best fitting cohort with their own therapy market value. It would be quite extraordinary for one single drug to replace all the others in the toolkit. Covid-19 is a complex mutating virus and hence the value of a variety of products with different intervention applications.