Member Info for Titania

Have these been corrected?

https://edition.cnn.com/2021/12/28/politics/covid-omicron-kids-hospitalizations-what-matters/index.html

https://www.dailymail.co.uk/health/article-10344237/Britains-doctors-hail-new-Covid-wonder-drugs-half-risk-death-virus.html

Professor Martin Landray from the University of Oxford, who leads the UK’s Recovery trial, says: ‘When you study a drug, the first thing you want to know is whether it works or not.'

‘We have had great results with dexamethasone, so it’s possible we may see even better outcomes if we push up the dose a bit.’

Trialling in Salisbury. Apparently those running the trial wanted to be able to visit the Cathedral.

https://www.biospace.com/article/additional-research-points-to-intranasal-defenses-against-covid-19/

Apologies if already posted.

https://www.docwirenews.com/condition-center/multiple-sclerosis-knowledge-hub/interferon-beta-1a-treatment-promotes-sars-cov-2-mrna-vaccine-response-in-multiple-sclerosis-subjects-3/

AZD7442 or Evusheld is a combination of two LAABs - tixagevimab (AZD8895) and cilgavimab (AZD1061). Initial research suggests not great performance for each and the combination. https://opendata.ncats.nih.gov/variant/activity

AZ's vaccine also not looking great at the moment. Deed a boost to their Covid portfolio. Did the historic SNG relationship part with friendship?

Intention to publish results 01/03/2022 in a high-impact peer-reviewed journal. Scroll down.

Last time the market rules meant they had to release the pre published results the moment the company received them. That was several months before. Not sure how much they stick to the dates.

SY2020

Its interesting that Polar Capital itself (the managment company not the fund) was tipped by HL as one of their top 5 shares for 2022. https://www.hl.co.uk/features/five-shares-for-2022

https://nypost.com/2021/12/20/biden-tests-negative-for-covid-19-after-being-in-close-contact-with-ill-aide/

https://www.dailymail.co.uk/news/article-10330245/Bidens-major-COVID-speech-Tuesday-NOT-locking-country-down.html

Several papers suggested Biden would be giving a speech today but nothing is scheduled on the Whitehouse live website today for a speech?

https://www.whitehouse.gov/live/

Lots of updated data but large red message saying Omnicron data should be interpreted with caution!

https://opendata.ncats.nih.gov/variant/activity

"Mobilizing an Additional 1,000 Troops to Deploy to COVID-Burdened Hospitals: The President is directing Defense Secretary Lloyd Austin to ready an additional 1,000 service members—military doctors, nurses, paramedics, and other medical personnel—to deploy to hospitals during January and February, as needed."

https://www.whitehouse.gov/briefing-room/statements-releases/2021/12/21/fact-sheet-president-biden-announces-new-actions-to-protect-americans-and-help-communities-and-hospitals-battle-omicron/

The number of unvaccinated is highest in London.

One more thought following up on the Omicron spike mutations are closer to the Beta strain.

Am I correct in remembering that SNG has been tested against Beta and shown to work?

I have been thinking about whether previous infection from beta could give better protection. I think the higher immunity from any infection (as opposed to vaccines), summer weather and younger population are important points. This is where my non-existing genomics is a gap.

But my observation is that Omicron might be genetically closer to Beta.

So its seems that the three mutations (Wikipedia) of particular interest in the spike region of the Beta genome:

· K417N
· E484K
· N501Y

It would seem that Delta does not have any of these mutations. But Omicron has them all. And a whole load more. So the South Africans who previously had beta Covid might be more protected than the Europeans who had alpha and delta covid.

For those of us with a Pfizer or Moderna shot, we have some protection against infection. Very few in the world have this. The variant is going to take off and we face high infections among the unvaccinated. Article:

A growing body of preliminary research suggests the Covid vaccines used in most of the world offer almost no defense against becoming infected by the highly contagious Omicron variant.

All vaccines still seem to provide a significant degree of protection against serious illness from Omicron, which is the most crucial goal. But only the Pfizer and Moderna shots, when reinforced by a booster, appear to have success at stopping infections, and these vaccines are unavailable in most of the world.

The other shots — including those from AstraZeneca, Johnson & Johnson and vaccines manufactured in China and Russia — do little to nothing to stop the spread of Omicron, early research shows. And because most countries have built their inoculation programs around these vaccines, the gap could have a profound impact on the course of the pandemic.

A global surge of infections in a world where billions of people remain unvaccinated not only threatens the health of vulnerable individuals but also increases the opportunity for the emergence of yet more variants. The disparity in the ability of countries to weather the pandemic will almost certainly deepen. And the news about limited vaccine efficacy against Omicron infection could depress demand for vaccination throughout the developing world, where many people are already hesitant or preoccupied with other health problems.
https://www.nytimes.com/2021/12/19/health/omicron-vaccines-efficacy.html?unlocked_article_code=AAAAAAAAAAAAAAAACEIPuonUktbfqohlSlUaCibVUNEjsh3Bgv3Oy6Y7gDrgJSOeSDBP1KEYDYaB8E7GdOxje943lXy9deN2DYUOFrZ03_MNeAtkURWpqZ-J35lcKStlpdq4G249g56IAO5lq3rjMWLibbt0ybbn50iIaDbqX7fNkiF0fHYTqptjcFGs2nUD1_2FRrYzgo8iqK9nUpNqRj4AZD2JvO3rA3h9OtaBZxLb7momSr0TGGGTzZPHteV2IEgFAknGTXh__W8_9NpcXdsWN6r1JBIkE9HsPbHbXZcFuJStvcmPndWkDw&smid=url-share

https://thehill.com/policy/healthcare/586368-supply-shortage-of-new-antiviral-drug-threatens-fight-against-omicron

https://science.thewire.in/health/pfizer-confirms-covid-pills-results-potency-versus-omicron/

Over a longer time period, "I would anticpate we will have poly-variant (valient?) vaccines and several anti-virals.... We already have 2 reasonable ones" BBC News at 1050.

He clearly expects more anti-virals. What other ones in the pipeline?