RE: Oxford Biomedica would be stupid not to take a leap of faith and contact this research team and offer to help them?29 Jan 2024 18:01
Have you actually given any consideration to the number of people who would need to be treated? In all likelihood you'd be long dead before your turn in the queue came around! Current CAR-T treatments are not only expensive but also use a lot of hospital resources; patients currently have a risk/recovery period of 2-3 months and it's not uncommon for them to have to be admitted to hospital throughout because the treatment can impair their immune systems (it may cure their cancer but in the "change over" period they can be susceptible to other diseases).
I'm not saying that the research is without merit but, unless they can come up with a pill or an injection, the pure logistics, let alone the economics, of the existing procedures make a mass roll-out unfeasible. Furthermore, OXB is about the delivery system rather than the treatment itself (if you like, OXB provides the inhaler not the drug) and unless the drug makers can come up with a means to swap out the T-cells without the need for a "transfusion" (the reason that they have to remove the old T-cells before replacing them with the new T-cells is because they can't "co-habit") and the consequential hospital stay then the type of delivery system becomes a fairly mute point.
The existing treatment just can't handle millions of patients each year, let alone tens of millions, hundreds of millions or even billions; it's not (necessarily) the cost of the treatment that is the ultimate stumbling block but the time (2-3 months per patient) and resources needed (individually tailoring the treatment for each patient, hospitals, beds etc.).
Finally, and it shouldn't be ignored, no drug company is going to pursue this because if it achieved all of its aims it might ultimately put them out of business! You only have to look at the treatment for stomach ulcers to see that this is true; for decades drug companies refused to accept evidence that stomach ulcers were caused by bacteria in the gut and that some, if not all, of them could (potentially) be cured by a simple, one-off dose of antibiotics because they were making £billions from ulcer drugs (such as Zantac) that tackled the symptoms rather than the cause.