est sensitivity is secondary to frequency and turnaround time for COVID-19 screening25 Apr 2021 23:40
Apologies if discussed before (linked paper is from January) but this is an interesting analysis. It discusses the limitations of PCR testing and outlines how frequency and turnaround time may be more important than sensitivity. In a nutshell, frequent testing with quick results is most effective in managing a pandemic.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7775777/"The COVID-19 pandemic has created a public health crisis. Because SARS-CoV-2 can spread from individuals with presymptomatic, symptomatic, and asymptomatic infections, the reopening of societies and the control of virus spread will be facilitated by robust population screening, for which virus testing will often be central. After infection, individuals undergo a period of incubation during which viral titers are too low to detect, followed by exponential viral growth, leading to peak viral load and infectiousness and ending with declining titers and clearance. Given the pattern of viral load kinetics, we model the effectiveness of repeated population screening considering test sensitivities, frequency, and sample-to-answer reporting time. These results demonstrate that effective screening depends largely on frequency of testing and speed of reporting and is only marginally improved by high test sensitivity. We therefore conclude that screening should prioritize accessibility, frequency, and sample-to-answer time; analytical limits of detection should be secondary."