Polymers reading27 Jul 2024 16:39
Polymers are being used extensively in drug delivery due to their surface and bulk properties. They are being used in drug formulations and in drug delivery devices. These drug delivery devices may be in the form of implants for controlled drug delivery. Polymers used in colloidal drug carrier systems, consisting of small particles, show great advantage in drug delivery systems because of optimized drug loading and releasing property.
Polymeric nano particulate systems are available in wide variety and have established chemistry. Non toxic, biodegradable and biocompatible polymers are available. Some nano particulate polymeric systems possess ability to cross blood brain barrier. They offer protection against chemical degradation. Smart polymers are responsive to atmospheric stimulus like change in temperature; pressure, pH etc. thus are extremely beneficial for targeted drug delivery. Some polymeric systems conjugated with antibodies/specific biomarkers help in detecting molecular targets specifically in cancers.
https://www.scirp.org/journal/paperinformation?paperid=62762
A large amount of effort has been focused on extending the release of small-molecule-based drugs by entrapping them in dissolution-based formulations consisting of cellulose derivatives and cross-linked poly(acrylic acid) polymers.
These approaches have enabled the long-term delivery of small-molecule therapeutics over a period from several days to weeks or months, thereby reducing the dosing frequency and improving patient adherence and compliance. Such long-acting delivery systems have revolutionized the treatment and management of multiple conditions, including psychotic disorders, pain, and advanced prostate cancer.
https://pubs.acs.org/doi/10.1021/acs.chemmater.2c03003#
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