Response from 4D about Mrx 0518 query17 Feb 2021 16:39
You are correct that the primary goal of Part A was to establish safety of the combination of MRx0518 and pembrolizumab, however it is not a dose escalation study and we do not anticipate using higher doses in Part B. Because of the expected safety profile of Live Biotherapeutics, we are able to commence studies with an initial high dose while maintaining a patient-friendly, clinically and commercially viable dosing regimen, removing the time and cost of traditional dose-escalation phases required for drugs with potentially less favourable safety profiles.