RE: FIT Bio7 Jun 2019 12:45
Noise -
Viral load can be expressed as absolute copy number or as log10 expression of absolute copy number. So, if you have 100,000 copies that is 5 log, 10,000 copies is 4 log, 1,000 is 3 log, 100 copies is 2 log and 10 copies is 1 log. Now, if you went from 100,000 to 10,000 copies that would be a 1 log reduction (5 - 4 log). If you went from 100,000 to 32,000 that would be a 0.5 log reduction (5 - 4.5 log) and so on.
So when you are dealing with viruses, and the rate that they replicate, this is clearly not a successful trial.