Member Info for RorkesDrift

If you ignore the 3-4 constant magic calculators on twitter then the community seem quite chilled despite an eratic SP.

My own thoughts are that FDA approval of a Regulatory study is a significant milestone. Between now and TO the SP will go up in steps, some small, some big. It wont go up in one big leap. FDA approval will be a big step, P1a data however good, less so. I say this because of the small number of patients, the variation in response and the fact that between now and commercialisation there are several hurdles to overcome. FDA approval endorses the precision concepr - not proven though

Free ride type strategy. Valid

To be fair without him this board would be very short of comedic value. I miss him and hope we see the day when we hear the distant sound of the pantomime horse and the swish of sausage again

He has been brilliant value and im looking forward to seing his entrance very soon.

clip, clop, september and chicken nuggers here we come.

These new drugs tend to bind to a specific receptor. These are found on tumour cells and partially hidden by stoma cells

If ava6000 is working then it should destroy stroma cells again favouring combination therapy.

Added to this some drugs are so toxic that systemic delivery is not possible. Precision could overcome that

No problem with a sceptical view especially since hard data is missing. Might need updating in a couple of months.

I think ive have had my 5-a-day of corn-y jokes

See what happens when you don't do QA

In other places the magic calculator is on max power today. When your volume of posting is regularly getting beaten by discord spam then the only answer is just make up facts and feed them into the magic calculator. Not sure why you would do it though - both RAh, Tom and Sean seem to hit daily posting target before i get up.

Oh hang on....

Thx for posting

Additionally you have to consider the therapeutic window. Some drugs can be taken at doses much higher than you see maximum efficacy. Some drugs eg dox have a sude effect profile where serious AEs are seen before max efficacy.

Im thinking drugs with longer half life dont take longer to start working. For example, a friend, took a double dose of Cialis instead of a single dose of triple dose of viagra. Cialis starts working faster than viagra but in local field trials the effects last a whole weekend. It has a faster onset and longer half life. Anyway thats what they told my friend at his latest visit to A&E.

You will be having a go at Mrs Nial next and believe me you don't want to do that.

If we get it effectively FDA saying there is enough evidence here to skip P1b and to enable REGULATORY trial.

I can see the new bus dev guy standing in front of BP and just grinning.

I think the pre-xmas warm up meeting did take place.

However, the telegram group posting it did take place is not proof even if it matches all the input requirements for the magic calculator. Its a self referencing approach that is null and avoid.

The reason i believe it happened is because the content is nothing new and presumably were published to have a positive impact on SP. Hasnt worked.

Good luck to that group and thanks for sharing.

Now to the important stuff. Xmas invites.

"Hands up for Haddock"

Ive heard a rumour. AS is going to invite a select group of LSE posters to a Xmas knees up at the Weatherby Whaler. Not only will there be unlimited amounts of chips but there might be powerpoint slides. Invitees will have to agree to wear Xmas shumpers and bang on about how many shares they have to ensure everyone feels like a "valid" shareholder. Elliot has suggested he utilises his deep and sonourous voice, normally reserved to make a serious answer to a stupid question, to lead the congregation in a rendition of "last christmas". Best of all but yet to be confirmed, Paul Hill and his girlfriend Carol Singers will be there to add some light weight giggling and ensure AS nods enthusiastically.

The organising committee were hoping to repeat the very successful covid pantomime but the chief villian exited stage left astride Spreadsheets the pantomime donkey. You cannot have everything but he sent a very nice postcard, written in crayons and hopes to be back next September

Does anyone know what type of biscuits they had. Im just asking because it influences Spreadsheets

Is it a full moon or has someone grabbed the magic calculator?

Thanks for posting - ill apply ockams razer and assume its accurate.

Not sure what AS is saying about funding. Mentions non-dilutive and then bangs on about US investors. Given he has adopted the word "optionality" then he has it - suggests neither option is close.

Narrowing the trial to a select group in order to increase options of success is standard e.g test fertility drugs in young women with tubular infertility. If a wider licence is granted Drs will assess and use or not. Risk to us is that there are 30+ patients in p1a - we should know where it worked and where it didnt this year.

Finally when his lordship was asked to leave was he directed stage left or stage right. Clip clop, clip clop....

My perception of the self help group has improved due to the meet and the change in members. I might even lend a hand...

Oh hang on

The problem with the continual rampathon is that it is based on made up information that any serious PI can check within minutes. However, it swamps everything else including all the really good stuff- at best it raises awareness but does little that is in-line with genuine LTH. There has to be a reason why the same 4 or so people each need to post several times per day. Im guessing they are either suffering from a strange form of OCD or they are on the make. If they stopped i think SP would go up.

Compare there efforts to a much wider group come publication of P1a. Im booking my twitter slots now.

RaH would be proud though. Excellent use of the magic calculator.

I'm torn - AS hasn't delivered to a stated date yet but also had knowledge of who was lined up for C7. Added to that the number of centres now involved should facilitate recruitment.

I'm thinking Xmas to start buying What Car magazine again

Indy I'm worried that one of your secret packages is leaking intimate a cavity....

What! Over? Did you say over?

Nothing is over until WE decide it is. Was it over when the germans bombed pearl harbour. Hell no