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Interesting connections, brilliant sleuthing!

This would be great.
We are all frustrated by how long it is taking to get this out and save lives. For a tiny company it would be hopeless trying to meet world demand on their own. This would mean production/distribution and pricing to large populations can happen but be outsourced.
Hopefully still some profit for SNG included. I do think they would like to save the world, Stephen Holgate is a doctor, and reputed to be very committed. However, I also think RM knows the value of this and will not want to give it away.

Another old article. Looks as if providing voluntary licencing in this way with an agreement on profit sharing is being done by patent holders to preempt compulsory licences being issued by the Indian Government with no profits.

If there is truth in rumours of licence agreements with India, there may be little or no cash upfront, but looks like this is necessary to gain a share of profits for patent holders from this limited research. If this pans out, another blinder by RM.

https://www.livemint.com/Home-Page/f0R9060osU7bENFNwlnx5O/Compulsory-licences-may-spur-more-voluntary-licensing-deals.html

Ah, slightly more detail here. The licences are royalty free until WHO declares end of emergency, or a vaccine is given approval, whichever is earlier. So presumably royalties are imminent if/when a vaccine is approved.

https://www.gilead.com/purpose/advancing-global-health/covid-19/voluntary-licensing-agreements-for-remdesivir

Looks like Gilead did this - agreement with four Indian companies to produce and supply Remdesivir to 127 other countries at a price of their choosing. No mention of money, but the agreement is royalty free until the end of the pandemic. Would be very altruistic of Gilead if there was not payment involved. This was some months ago, but could be a model.

https://www.newindianexpress.com/business/2020/may/14/four-indian-firms-ink-licensing-pact-with-gilead-for-covid-19-drug-remdesivir-2143054.html

Sorry Poker I didn't mean to copy you!
This board moves so fast it is hard to keep up.
I rarely post because if I have something to say someone has already said it before I can type!
Which is all great.

But Mac, RM does not seem out of his depth at all.
The Phase III trial is already planned and funded.

It will be carried out in 20 countries by Paroxitel ? and is due to begin recruitment hopefully in November, so in the next week or two. In addition it has priority status in Uk where 20 hospital will be contributing to the total of 900 recruits targeted in the protocol. RM has suggested that recruitment will complete within 2 months and it may be faster.

They may be able to have an interim data readout so for patients recruited in less than two months with a view to an emergency use application.

It seems likely that Synairgen will need a bigger partner to help when demand vastly exceeds the 100,000 doses per month Synairgen have planned for 2021 on their own. But, RM and Synairgen are doing very very well going it alone so far. Possibly far faster than if they had 'help', and without giving away anything to BP.

No coverage from BBC or Guardian so far. Maybe they will have more depth coverage over the weekend with interviews etc.

While vaccines are great news for the world it has meant a less than sparkling week for us.

Thinking about this though. at the moment all priorities are going in to firefighting people who are dying or at death's door. It may be that only when vaccines have cleared the sheer load of cases that anyone will have space to worry about the less severe cases and get tests result to treat early/try to keep people out of hospital.

At the moment we are only able to plan for 100,000 treatments per month. This demand will be far exceeded even with a vaccine for people who didn't sero-convert (the 10% and probably increasing as the vaccine wears off) and the people who couldn't and didn't take it.

Perhaps it is only with a vaccine in action that thoughts will turn to the SNG niche.

Hope this warrants an interview, clarifying that P3 is imminent and we are close to finishing recruitment for the home trial.
Any other hints on progress towards approval also welcome!!

Pmjh - There had been a lot of public questions on the vaccine to Matt Han****. Then Merryn Somerset-Webb argued that we also need to keep going with therapeutics and understanding how we live with covid in the meantime. How we now know that we can go shopping etc and are getting better at this. She then mentioned continued need for therapeutics. Firstly mentioned dexamethasone and then a study of inhaled interferon. She did not mention us by name, but clear what she was talking about. She gave a long speech and the Synairgen bit was not taken up by Matt Han**** further.

She writes in Moneyweek and is very well informed, so would know exactly about Synairgen and what she was saying I am sure.

Writing this from memory after watching it last night, so sorry this is not verbatim.

https://www.thelancet.com/journals/lanres/home

yes, we are there

Interesting point Oxford.
One of the interviews with John Bell discussed this and he said 'we won't do this until there is a good treatment'.
Perhaps there will be soon...
I do think it is a bit like something they would have done in concentration camps though, so not sure about it myself.

Good point Formygirls.
My understanding is that a normal hospital bed is around £500 per day and ICU around £1500 per day.
So Synairgen could easily save on this in 3 normal bed days or one ICU.
Plus time of exhausted staff and pressure on beds could be saved.

If it is tonight, might be here in the online first section.

https://www.thelancet.com/journals/lanres/home

Ha Ha!
If it isn't there by 11.32 I will stamp my foot!

Crossed my mind that some of the government enthusiasm/talking up the vaccine this week could have been to distract from not getting a US trade deal if we breach the Good Friday agreement, which we are likely to do if we don't get EU trade deal by next Thursday. That on top of Bojo's aides being busy squabbling between themselves.

Interesting he said that about vaccine. It is the 'quality control' for drug study data, so that makes good sense.
Good luck to them trying to get 96 infections one year before the end date of the trial published.
Good on him for pointing out that evaluation will be on scientific merit not headline grabbing.

Yes, as someone pointed out, Mail article came out at 6.30 which is US embargo time. Uk is 11.30, so might be tonight.

The Lancet article on Ethnicity and Covid infection of today was in the Guardian today, so if tonight is the night we should be hitting more press tomorrow.

Whoop Whoop!

Oops, if Daily Mail has seen it as embargoed until published, sounds like may have jumped the gun in excitement at the scoop.
Well done him!!

No mention of it yet in Lancet online, but rings true with what we were told from Tom Wilkinson's talk, and seems to be far too much detail to be made up.
So exciting!! Maybe the government will start to talk about us now, and scientists can't be 'sceptical' anymore.

Can't wait to see it in print. Hopefully tomorrow.

Certainly seems to need much more data over a longer time period.
I am a bit concerned that UK have been told they will lose their doses if they don't pick them up.
I don't think the objective process of assessing data and considering whether to give approval should be put under that sort of pressure.

Maybe the people who got vaccine were so unwell with their painful arms that they stayed in and didn't get much chance to catch a virus!

A real concern would be that the 10% who were not protected are the same 10% with some kind of immune system dysfunction, or very elderly, who get severely ill/need ventilators and die. This excellent headline figure could still be limited in reducing load on health systems and deaths.

A second big issue is whether people are protected from infection, or just become asymptomatic carriers. I doesn't sound as if the protocol even asks this question.

A very bad situation would be failure to protect those most at risk while rendering everyone else asymptomatic carriers. That would mean high levels of virus circulating in the community with no clues as to who should isolate and track and trace becoming more useless than it currently is. I do think there should be answers to these questions before approval is given. I hope it is not just rushed through.