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Fly, in case this helps.

The P2 had two arms.
The hospital arm finished and the positive result was published in the Lancet in November.
The second (at home) arm was very slow to fill after it missed the first wave. They finished recruiting almost a month ago, so the last recruits are finishing 28 day follow up around this weekend. We will expect unblinding and data analysis from now, so readout in ? weeks.

The P3 SPRINTER is a follow on for hospital treatment after the data published in November. It has taken a while to get going, but probably actually fast in terms of clinical trials. First recruit was announced around 12th January.

We have also been included in the US Activ-2 trial which is a p2/3 trial for at home treatment. This has been announced by Synairgen in RNS just over two weeks ago, but we await official US announcement of this any day now.

Jonathan Van Tam tonight said the government aim is not to eradicate covid, but to make it possible to manage in the community. Grateful for this information rather than constantly second guess what the government plan is (if any).

So,
1) There will probably be a lot of cases acceptable below hospital capacity threshold/deaths.
2) Many cases give the opportunity for many new mutations.
3) As you vaccinate and give immunity to the population there is selection for new mutations immune to current vaccines.
4) And massive potential for long covid cases.

This model will increase likelihood of our living with successive mutations probably indefinitely. There is always risk that one of these new mutations will have higher mortality. So far they seem to have been differences in spike protein, but if they get better at evading our immune systems that could go very wrong.

However, this model will make treatments a massive market for a long time to come.

This is terrible news for all the elderly and vulnerable who have been given a vaccine which will probably be useless in a few weeks.
I hope the message gets through to them that it does not give them 'freedom' before they take risks hugging their grandchildren.

Two great posts, thanks JoeyDiamond!

Hope UK data will start to show some vaccine effect soon. Horrendous to think it won't work!
Also horrendous that UK variant will be bubbling under to start a new surge around the world, probably followed by what could be worse SA and Brazil variant waves.

The only possible positive to extract from it all is that there will be massive ongoing market for SNG.

I so hope our government now aim to squash cases as far as possible then have a working track and trace system to keep cases low.

The benefit in the over 80s group in the Israeli data only began at around one month after the start of vaccine roll out.

Ours starter around Christmas and was initially probably slower than in Israel.
People I know (elderly and medical) who were in the early weeks all seem to have had Pfizer rather than AZ.

So hopefully we will be expecting effects to show from about now going forward.
Really do hope it is working, probably just too early to see any big effect yet.

Guardian article, sorry if posted. Interviews Peter Horby.
No mention of sng, what a surprise!

https://www.theguardian.com/world/2021/feb/02/even-with-vaccines-we-still-need-treatments-for-covid-so-what-works

In case of interest..
Was expecting to make tax bill payment by this deadline but logged on to HMRC website to check for any deadline extensions.
Found you can arrange a payment plan by logging in through the government portal and am now paying it in instalments over the next six months. There is 2.5% interest payable.
Would have been happy to pay, but might as well benefit from this offer.
Some people may find this very helpful.

Don't think I qualify as an expert..
But yes. At the moment people are getting positive tests for covid, but don't know which variant they have.
As there become more variants any specific antibody treatment will increasingly not cover all of them.
I think Anthony Fauci himself has said in the past few days that they will become obsolete.

Plus the practicalities of giving a (one hour) I/v infusion to an infected person are not great. They either need a lot of infected people to move around to treatment centres or people go to the homes of infected people and wait while they have the infusion and post infusion monitoring taking any required resuscitation equipment with them.

Just don't see this working out as a big advance in covid treatments particularly in the home setting.

Thank you so much for all your amazing sleuthing and generosity in sharing it with us PJMH. It must have been exhausting. We are all so grateful to you. Good luck. Hope we will hear from you again. Richlist

Inhalers and spacers are very good for asthma medication, but I don't think they need to get as deep into the lungs as the interferon used here.
Ventolin (salbutamol) is a bronchodilator and works by relaxing the muscles in the upper levels of the airway to open them when constricted by an asthma attack. Steroids used for asthma will work by reducing inflammation at this upper level in the lungs to prevent the muscles constricting during an attack.
I think the use of interferon needs to get right down to alveolar level and this needs the finer mist provided by the fine mesh nebuliser.

I think there is a big difference between these nebulisers and inhalers.
The fine mesh here makes for a finer spray with smaller droplets of the interferon.
This means it will be inhaled much deeper into the lungs to reach the treatment area.

Using inhalers may be possible, but if the interferon doesn't get to the right place they won't achieve the same treatment benefit. There is a reason Synairgen have taken 15 years to get to this point and this is all part of what is included in their patent.

Well done for making a complaint to the BBC.
I complained about some of the vaccine news reporting (was not factual) recently.
I got a very receptive and considered response very quickly.

I don't want to be Mrs. Angry, but had always thought of BBC news as good quality independent reporting. They have not been doing themselves any favours with some of their reports/interviewees recently.

So many thanks pjmh and Dafad for magnificent sleuthing!

The UK have science to be very proud of. We may get selective UK centric reporting, but our science has made a major contribution to the fight against Covid.

Good science requires rigour and integrity. This seemingly random decision without data in the public domain to even support it bypasses the standards expected of the science we should be proud of.

There may be logical arguments for why this could have benefits, but they are not the way good standards of science work. Shameful.

But scinv, if the vaccine had been tested over 10 years we might have data to show the optimal dosing regime from all these options.

Within the timecourse it is remarkable to have the data they have, but the protocol used is what they seem to have efficacy data for and therefore the treatment regime for recommended use. The point of drug trials is to show rigorous evidence of testing and proof of efficacy and safety. It is not a basis to then run your own experiment on your population (unless you are Russia or China). Particularly if this could increase risk of making the vaccine useless for the rest of the world.

Also shameful is that if they think there is data to support this decision it has not been put into the public domain for immediate evaluation.

Alarming that the vaccine the world has been desperate for could now be used in an untested protocol with possible increased risk of selecting for mutations. This could evade the immunity conferred by the vaccine and render it useless for the world.

Am wondering what the UK contract with Pfizer is. If I were Pfizer I might not be keen on giving doses of a precious drug (and very lucrative product) to a country who would use it in a reckless way and may render it useless. Pfizer will have no problem finding takers for all the doses they can produce.

When Russia and China use inadequately tested vaccines we are very shocked. UK are already the source of the new higher transmission virus. How do we look to the rest of the world? I feel so ashamed of the chaos and carnage at every turn this government seems to achieve.

Yes, shops don't really seem to be keeping to social distancing.

I went to buy Christmas food. Clue, it wasn't just food, it was *** food.
The security guard, responsible for distancing and crowd management, told me I could go in while standing firmly in front of me. I said it was 2m hoping he would stand back to give me distance to walk past him. He just laughed and said. 'You'll have trouble with that in here'.
Might laugh if it was funny.....

What a great RNS! Fantastic news!

Am wondering about the change of nebuliser. Was the old one with a mouthpiece and this one with a mask? If so, SNG001 should also reach the nasopharynx and olfactory mucosa in this trial where they did not in the last one. Seem to be suggestions that olfactory mucosa are an important site of infection, so just maybe this trial could give even better results.

Have been cross at the way BBC, even a GP expert, have been talking about this vaccine and 'herd immunity'. They are certainly not making clear that there is no evidence it prevents infection/transmission and would produce herd immunity. Would not normally do this but have written to BBC complaints about their own vaccine 'misinformation'. Chris Whitty seemed to spell it out the other day, but the limits of these vaccines are taking a long time to sink in.

From Guardian today:
The same deletion was spotted when samples of virus were collected from a Cambridge patient with a weakened immune system. The patient was treated with convalescent plasma – blood plasma containing antibodies from a recovered patient. The virus acquired the mutation during that treatment and may have become more resistant to the antibodies. The patient ultimately died from the infection.
https://www.theguardian.com/world/2020/dec/14/how-a-new-covid-strain-may-have-spread-virus-in-south-of-england

So, this mutation may have arisen in the context of selection in someone given antibody treatment.
Just have to hope it does not evade vaccines.

Still plenty of need for SNG down the line.

From Guardian today:
The same deletion was spotted when samples of virus were collected from a Cambridge patient with a weakened immune system. The patient was treated with convalescent plasma – blood plasma containing antibodies from a recovered patient. The virus acquired the mutation during that treatment and may have become more resistant to the antibodies. The patient ultimately died from the infection.
https://www.theguardian.com/world/2020/dec/14/how-a-new-covid-strain-may-have-spread-virus-in-south-of-england

So, this mutation may have arisen in the context of selection in someone given antibody treatment.
Just have to hope it does not evade vaccines.

Still plenty of need for SNG down the line.