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https://www.thelancet.com/journals/lanres/home
yes, we are there
Interesting point Oxford.
One of the interviews with John Bell discussed this and he said 'we won't do this until there is a good treatment'.
Perhaps there will be soon...
I do think it is a bit like something they would have done in concentration camps though, so not sure about it myself.
Good point Formygirls.
My understanding is that a normal hospital bed is around £500 per day and ICU around £1500 per day.
So Synairgen could easily save on this in 3 normal bed days or one ICU.
Plus time of exhausted staff and pressure on beds could be saved.
If it is tonight, might be here in the online first section.
https://www.thelancet.com/journals/lanres/home
Crossed my mind that some of the government enthusiasm/talking up the vaccine this week could have been to distract from not getting a US trade deal if we breach the Good Friday agreement, which we are likely to do if we don't get EU trade deal by next Thursday. That on top of Bojo's aides being busy squabbling between themselves.
Interesting he said that about vaccine. It is the 'quality control' for drug study data, so that makes good sense.
Good luck to them trying to get 96 infections one year before the end date of the trial published.
Good on him for pointing out that evaluation will be on scientific merit not headline grabbing.
Yes, as someone pointed out, Mail article came out at 6.30 which is US embargo time. Uk is 11.30, so might be tonight.
The Lancet article on Ethnicity and Covid infection of today was in the Guardian today, so if tonight is the night we should be hitting more press tomorrow.
Whoop Whoop!
No mention of it yet in Lancet online, but rings true with what we were told from Tom Wilkinson's talk, and seems to be far too much detail to be made up.
So exciting!! Maybe the government will start to talk about us now, and scientists can't be 'sceptical' anymore.
Can't wait to see it in print. Hopefully tomorrow.
Certainly seems to need much more data over a longer time period.
I am a bit concerned that UK have been told they will lose their doses if they don't pick them up.
I don't think the objective process of assessing data and considering whether to give approval should be put under that sort of pressure.
Maybe the people who got vaccine were so unwell with their painful arms that they stayed in and didn't get much chance to catch a virus!
A real concern would be that the 10% who were not protected are the same 10% with some kind of immune system dysfunction, or very elderly, who get severely ill/need ventilators and die. This excellent headline figure could still be limited in reducing load on health systems and deaths.
A second big issue is whether people are protected from infection, or just become asymptomatic carriers. I doesn't sound as if the protocol even asks this question.
A very bad situation would be failure to protect those most at risk while rendering everyone else asymptomatic carriers. That would mean high levels of virus circulating in the community with no clues as to who should isolate and track and trace becoming more useless than it currently is. I do think there should be answers to these questions before approval is given. I hope it is not just rushed through.
It does sound as if this is very early/small data set.
They will be submitting the data they have in 3rd week of November for 'emergency use' based on the minimum safety data period required by FDA.
I thought emergency/compassionate use was for life threatening conditions with no other treatment available.
Not clear to me what situations require 'emergency' administration of a relatively untested vaccine to healthy people.
I suspect FDA may need more data and take longer than they hope to give approval for a vaccine in healthy people in spite of the urgency of the pandemic.
From what I can see the Lancet is weekly and on a Thursday. No mention of SNG001 in the current edition from last Thursday, so hopefully one Thursday soon.
Agreed though, all credit to bagitup and I think Bella. Don't think for a moment they are making this up, but we shouldn't let excitement run away with us. May be Lancet space is filled for a few weeks ahead or something got lost in translation.
May have trouble sleeping with the excitement though!!
Since 20th July we have been very excited about the potential for SNG as a treatment, but various reports or views from scientists have contained comments like 'scientists are sceptical', 'nothing has been published', 'has not yet been peer reviewed'.
Action has been taken very quickly behind the scenes with progressing trials. I do think that a Lancet publication of the P2 results (hopefully true) will be a massive piece in the jigsaw. We may then see everyone talking about SNG and realise this is what we were waiting for and there is no conspiracy.
I can't wait to see if we are really published this Thursday.
Great information Bagitup!!
The Lancet is the or one of the best journals for medicine, so must have had excellent reception if it is accepted there. From what I can gather it seems to be published on Thursdays. So exciting..
Trying to think of possible timelines here. RM made clear that they are progressing this as fast as possible!
From Joey Diamond's post. First they need IND, then need to wait for 30 days before they can start the trial. Once they have IND they can apply for EUA for people not eligible for the trial.
So, if they anticipate a November start, they expect IND by next week. Hopefully this would be worthy of RNS.
The trial is said to be randomised placebo controlled, but not double blind. This seems to mean the clinicians will know who is getting SNG001 and who is getting placebo. As the trial progresses it will be clear how well it is working and possible to do early analysis and maybe stop the trial for benefit.
So, we certainly may see EUA much earlier than the final P3 results. Maybe even full approval much earlier that final P3 results if stopped for benefit. The need for SNG001 will be more and more desperate as the winter progresses.
Looks like the AIM award winners will not be announced until December after a media campaign now.
http://www.aim-awards.co.uk/media-room/
Rasher you are talking rubbish. There have been pandemics through history and quarantine has always been part of the response. The word was coined from the 40 days ship cargoes were held in Venice during the plague. You are entitled to hold views which most people find very offensive. However please try keep your facts somewhere close to the realities of history.
Link to video posted earlier by volatility. see 13mins 30.
https://www.youtube.com/watch?v=BzK7lCjN6Jw
So maybe fundraise up to 160 million shares at £3 per share to fund massive production and sales, then takeover at £8 billion. So £50 a share exactly. Nice to have a dream!