Member Info for RayPointer

Here's another article about the importance of CD8 memory cells

https://www.ncbi.nlm.nih.gov/pubmed/29664561

But hasn't Lindy already proved that CD8 memory cells are important in the SCIB1 trial?
In addition immunobody also leads to the creation of CD4 memory cells. I would imagine that together they can launch an immunobody style attack should the cancer re-appear.

I remember Scancell being relaxed about the original batch of SCIB1 losing its potency and so being withdrawn several years into the SCIB1 trial.

on HL.
MMs must have knocked off early

Yes, most likely he is having a good sleep after another Chelsea win.

Couldn't agree more Wild.
Many clever scientists appear to be Scancell fans.
The blind Aim market sees Scancell as a failure since the SCIB1 trial did not lead to a deal.

By the way, you missed "Take care" off your post. Most remiss of you LOL

Yes but only as part of PBP
Currently this is centred around Modi3 and aimed at specific cancers.

Not so researcher.
Victory covers project blueprint only - Modi3

But, of course, the most important event is Burnley escaping relegation LOL

Yes, it will be fascinating to see how that trio working together pans out.
Who would not want to work on project blueprint?

"December- month off everyone excited about coming year of data lots of interest and coverage in scancell a company now with an mcap stable around £500 million....scancell take on 2 new staff"

Ira Mellman and Ugur Sahin?

Well said Knowlesi

I bumped into Lindy in the street today.
She was chasing the company cat TCell, who in turn was chasing a mouse.

Lindy
"Come back TCell, have you any idea how much transgenic mice cost?"
Ray
"Looks like the mouse is winning"
Lindy
"You wouldn't believe that the mouse had stage 4 lung cancer yesterday"

Interesting deadly.
Relevant to the recent conversation with inan.
If TCells can be stored for later use on any patient, this would remove the need for taking blood from the patient and extracting TCells.
So, a possible improvement both in cost and speed to the Biontech process.

That's a blatant ramp crumbs
You forgot to mention that he had overalls on and a chamois leather in his hand

I bumped into CH this morning in the pub and he was buying all the drinks

Chelsea

Close process starts at 12:30

https://www.lseg.com/areas-expertise/our-markets/london-stock-exchange/equities-markets/trading-services/business-days

Have a good Christmas.

Hi inan
You may want to look at the LLOY BB
Some very heated Brexit debate going on there

Yes, it occurs to me that anything expressed on a spiral structure (e.g. DNA) has nowhere to hide.
Lindy realised at some point in her research that this is an important factor leading to high avidity.

The Genentech/BionTech collaboration came to much the same conclusion after years of investigating mutations. Something expressed deep inside a molecular structure has little chance of having high avidity.
Maybe they should have phoned a friend LOL

oin you in those sentiments Crumbs

Evening Wild.
Yes, I really enjoy re-reading the Scancell documents and re-viewing Lindy's presentations.
I learn a bit more each time.
I like slide 30 as well, where Lindy is giving us some clues as to how she selects her targets,

So spiral structures are good choices. Perhaps they are more rigid than other structures and, as such, are more likely to have a high affinity when binding either to an APC or a tumour cell.
In contrast, the looser structures, are likely to flap around more in the bloodstream, and so they tend to disconnect more frequently before activation takes place.

That's the view of a physicist anyway LOL

You too Inan and thanks for all your insight through the year.