The latest Investing Matters Podcast episode featuring Jeremy Skillington, CEO of Poolbeg Pharma has just been released. Listen here.
EMA Top 5 - we're picked from 5 treatments on the rolling review list but further along than SNG. Mostly MABs some of which the FDA have already stopped using in the US due to variants. Top 10 to come.
Camostat has officially failed Activ2 due to futility - this was confirmed in a release on the 24th.
Activ2 Protocol update for non-infused agents is due.
Sprinter Trial ongoing and running in multiple countries.
H2 starts tomorrow....
Nice posts doc, and 100% correct. Information flows from different directions, and has been widely shared between.
LSE - Guild - Reddit - RNS - Twitter - Telegram Groups (s), etc. Even from private chats. It has all contributed to the knowledge and Information gained. No one source, no one person, no one of these necessarily better but different with different feel and on different technologies (which often meets individual needs). Each source/group/input has advantages and disadvantages - we are after all, all human and fallible. We are and we should all be better for it.
Best regards.
Owl1l - you have to message one of the Mods.
However, I think there is an actual limit on the number of people that can be added to a reddit group and its at its limit (due numbers joined - some are older non-used or duplicated accounts.) I know the Mods identified some duplicates which were removed but unfortunately the limit was hit again. Don't know if they were able to clear out additional accounts as they would need to be able to identify those that we unused, which isn't necessarily easy to do.
Indian Variant has already taken hold. The rest is now just time and impact.
Thanks TT - Really appreciate seeing that.
I've shared on Reddit Group - from your post history I believe you'd be cool with this.
Information does get shared among various groups and back here.
Apologies, if not cool with you.
Best PJ
Nice Post Doc - agree with pretty much everything you said.
All parties really need to cease and desist - just filter each other and move on FFS.
The reddit group is not a private club....
All you have to do to join is 'join the Synairgen group, then send a message to one of the mods, Noel or Oxford'
I'm not a mod but as long as you're not a tw at or trolling I'm sure anyone is welcome. They let me in so the bar is low.
As others have said, there are many of us across multiple groups and anything significant is shared/posted.
Its nice to see a better vibe here this weekend....
This may be true - what will they do with 40% of the vaccine doses once they have them is the real question...
ExperiencedFool - if your chat is knackered you'll need to create a new account. Once done, message mods with your new account and they'll add you into the group. It'll appear under your chat groups once added. :-)
Global Vaccine Rollout..... of course we need to do this.
Now consider the 40%+ of people that won't/can't have vaccines, e.g. US, EU, UK. Even if this is reduced to 30% or 25% IT WILL NOT BE ENOUGH. And then there are new strains and reinfections - this will be ongoing as the leading experts have stated.
And then you have stockpiling. Alongside home use, f approved for hospital use every hospital /clinic will almost certainly want to stock this - that's a lot...
It will still save countless lives.
Great line Doc, I'll have to steal this :-)
I believe they stated AGILE is for P1/P2a drugs. SNG is way past this point.
You need to look at this as SNG as different stages of treatment:
Pre-Hospital Infected: This is Activ2 (US) p2 into p3 and Home Trial (UK) P2.
Hospital Stage - UK P2 and now P3 International. This is why RECOVERY/PRINCIPLE are now not applicable.
There are 2 other stages that SNG are not currently being trialled for:
Late Stage (Ventilation) and Pre-Infection (does SNG protect from Infection?). At this point adding SNG to the PROTECT trial makes sense as an opportunity, however with everything else it is not likely to be a priority for SNG at this time and not part of the critical path.
Any of the trials above can trigger a number of events, including EUA. EUA will almost only be provided for purpose based upon the relevant trial, e.g. the stage of Treatment. So Home Trial/ Activ2 EUA would be pre hospitalisation AT HOME treatment.
Hope this clears this up somehow.
Can we now close off conversations on why are we not on RECOVERY/AGILE/PRINCIPLE. Yes, perhaps we should have been on RECOVERY but that is not the way forward now. The above trials being conducted are and we need to support that.
AND to be clear we have to understand that the Urgent status SNG has been conferred for P3 means SNG has patients for trial - if SNG didn't have this then there would be no UK patients on P3 trial - this fact was made clear by RM.
We may have expected/wanted better/more support from UK Gov but this is where we are and ultimately that may work out better for all of us.
'Yet a successful investor can get nine women pregnant in one month......'
Which is a risk no sane person should ever undertake...
Still 42 days to Mid March. Theoretically possible as someone discussed 105 sites but I don't think its likely if we only have 40 patients so far and limited UK sites.
There's conflicting information - we also heard about various trusts being excited/involved with trials. So maybe accelerates as multiple hospitals become involved (if that is what is happening).
If a trust in the process of coming on line and it involves say 4 hospitals and they recruit 1 or 2 per day going forward then that's 40-80 patients added by mid march. If this is 2 or trusts then you see numbers are entirely doable but need to come online ASAP.
In theory, the UK could jump ahead and look at the Home Trial data .
Nah you're right - not going to happen. USA baby!
In (with SNG001 Hat and "FightCovid/Drug of Choice for the 21st Century T-shirt" obviously)
I might have posted something quite direct....
No not those orders....
To coordinate with the P3 dosing, Activ2 and EUA, PJ is releasing a new range:
https://imgur.com/a/KSEEADW
Happy Friday Synners
Also, pricing may be different for different markets (for various reasons), e.g. UK could be £2k, US $3K, EU 2.4k EURO.
£2K is approx. $2700. When speaking in generic terms at a national level I may say about or around £2k off but the actual price may be slightly more which wouldn't necessary be noticed - lets say the actual final price is £2200 that is $3K.
Either way not really much difference (10%) on what was stated as probably around $3K. So PLEASE stop this nonsense - I know people have lost some faith here but lets keep it real.