Member Info for Patagucci

Is that it then for Activ-2?

I guess I concur with what others have said. Although I’m still holding. I see this as a loss don’t get me wrong, but whatever synairgen is worth, I believe that is more than what it’s currently valued at.

Deep dive data and Activ 2 needs to come in and save our investment.

To the OP, like many of us here, you did your research and we fell on the wrong side of results. My lesson here is if you do take a risk, only have it a small part if your portfolio. I was far too heavily invested.

Today 2 RNS,
1) polar are below 3%
2) Polygon over 25%

Share price dropped 11%, pretty uneventful day overall, I would expect a slight increase in sp tomorrow if I was trying to predict it.

Maybe I’m naive, but I honestly think results just simply didn’t go our way. No one saw it coming. I have faith in activ 2 and long term I believe the company will succeed. But for now, I’m accepting my loss and waiting for updates from the company.

My take on it, as it is now, it’s pretty awful and the SP reflects that. In my mind I accept I’ve lost my investment.
However, Activ 2 does have the potential to bring good news to the company. If it does, I would certainly hope to regain the good proportion of my initial investment, and I wouldn’t even say making money would be impossible given how low this company is valued.

So in short we can take two paths, the most likely one going to nothing and loosing my investment
But the other one less likely giving an overall good result.

On the one hand I think slim chance Activ 2 will save us, but I would say there is more chance of that happening than what I thought negative P3 results would be only a week ago.

Regarding long covid, if steroids suppress the effect of INF, then surly long covid results will also be a dud.
If they were good I agree that would be game changing.
Our best bet imo is to sit tight until activ 2 results, and beginning activ2 P3. If that shows Synairgen really does work, which imo the fact it hasn’t been kicked off yet shows it has every chance, that’s going to blow this thing back to all time highs. But they are some big If’s.

Alhambra, I don’t know how easy that would be to implement. The admisión of the drug isn’t the simplest and at the cost per treatment I doubt that would really work. But with the drug having no side effects it’s an interesting theory.

Would an EUA and orders be a likely outcome? I’d love to have the guts to buy big now, but already I’ve gone to deep on this. If I can get a decent amount of my initial investment back I would be over the moon.

gggg21 - do you see that as a good thing?

It’s heart breaking. I feel crushed. You have to make your own plan on what to do from here.

personally, the lesson I’ve learn is even if on paper everything seems perfect, nothing is guaranteed.

Im going to spend the next 10 years maxing my stocks and shares isa, investing in index funds, slow and steady try to regain my losses. But it’s a very long path ahead of me.

I still hold a very small amount of hope in SNG, haven’t sold my shares yet.

*fire to put out

These are outpatients. And we are hoping because of this they aren’t taking steroids and it will show better results. However, does that mean these patients will be less ill? We all know synairgen needs a first to put out.

I still can’t believe it. The decrease in death rate and that we are still in Activ-2 is all that’s keeping my hopes up.

-Synairgen did reduce the death rate during 35 days, but wasn't significant in reducing length of hospital stay. No side effects.
-We have progressed so far in Activ-2, surely we must have had some promising data?
-If the US Government sees that this drug is effective at reducing death rates, and that is their main concern, an order could follow?
-Long term may have COPD/asthma potential and with patents the company own etc at very worst could the company be bought out or recoup some losses this way?

I am absolutely gutted. I still cant believe it, but clutching at straws is what I have said above accurate? I think I am going to hold this out for many years, accepting I have lost everything I've put in for now.

Be good to see, certainly large volumes recently despite the SP falling. I would love to see a new II on board!

Great write up. Results aren’t delayed as of yet. Need to just accept its not going to be done quickly but it is going to be done correctly. As you can see from your post, the potential of this drug is huge. Synairgen are just a positive P3 away from greatness. If we still haven’t heard by the end of March, or if we get negative news then I’ll change my view. But until then, sit back, and relax.

Recently SNG share price has dropped? Did you sell? I certainly didn’t. Every day there seems to be more buy volume than sell volume. I feel this company is so niche that if you’re investing in it you must be fairly aware of the situation and therefore aware this is a long term game.

Can’t help but think 1) who is selling, because surely most PI’s aren’t letting shares go following this drop.
2) when the day of P3 does come, with not that many shares in issue, and most of the PI’s I presume not selling Immediately, is this not the perfect storm for a serious rise.

This is kind of a big deal, no?
-Sprinter results Q1
-Activ 2 Q2
-Anytime EUA or government orders.

With all the new jobs recently, NIH tweeting about inf, etc, it's all looking very positive.

Ah ok, I was wondering with the recent drop out in activ 3 if it was going to be used on inpatients… apologies.

Q2 2022, is that the expected end date for Activ 2, I would have thought it would take much longer than that?

Sorry if this has already been discussed but on the nih web page, what does it mean by repurposed regarding SNG? and the end date of Q2 2022

https://www.nih.gov/activ/nih-funded-activ/activ-associated-clinical-trials

Are we expecting Activ-2 phase 3 trial for SNG to be completed by Q2?!

On Activ 2 website isnt SAB-185 still going? Or is really just SNG left now?

If so, this is just more fuel to the rocket.