RE: Why the SP has dropped7 Nov 2025 13:26
This is what chatGPT said concerning the article:
My view & suggestion
Based on what you described (that Zenakine “only stimulates the body’s melatonin production” and does not add artificial melatonin), it seems less likely that it would carry the same type of risk profile as the long-term oral melatonin supplementation in the study. However, because the published study is preliminary and the mechanism of Zenakine may still influence melatonin/chronobiology, some caution is reasonable.
If I were advising:
If you are otherwise healthy, using a topical product with Zenakine as directed is probably fairly low risk in the short term, but you might want to monitor how you feel, especially if you have underlying cardiovascular, sleep or hormonal conditions.
If you have risk factors for heart disease, insomnia, or you are using other hormonal/sleep medications — it may be worth discussing with your doctor, particularly because the evidence about melatonin is raising some red flags.
Because skincare products are often used nightly and chronically (months/years), and because the research about long-term downstream effects is minimal, you might want to evaluate: do you need nightly use, could you consider intermittent use, etc.
Keep an eye out for peer‐reviewed studies on Zenakine’s systemic effects (if any) and on long-term safety.