PRM5 Apr 2012 08:28
Stroke Biomarker License to Randox
5th April 2012, London. Proteome Sciences plc, a global leader in protein biomarkers has today granted a non-exclusive license to Randox Laboratories ("Randox") of Crumlin, UK for its portfolio of stroke biomarkers.
Proteome Sciences has established an extensive portfolio of patented plasma biomarkers of stroke and other brain damage-related disorders discovered in partnership with the Biomedical Proteomics Research Group at the University of Geneva ("BPRG"). These markers are rapidly elevated in blood of patients undergoing both haemorrhagic and ischaemic strokes and offer the potential to identify those patients that would most benefit from thrombolytic treatment within the first 3 hours after onset of symptoms. The research with BPRG has shown that a panel of 5 blood proteins is able to accurately rule out 90% [9 out of 10] of patients that have not had a stroke but who may currently be misdiagnosed in primary care and allows 90% [9 out of 10] of genuine strokes to be confirmed within minutes of the onset of symptoms. Together, these results have the potential to transform the management of acute stroke and ensure more patients receive thrombolytic therapy. These provide a highly effective way to minimise long-term disability in ischaemic stroke, reduce the cost of care and considerably improve the quality of life for stroke patients and their families.
Under the terms of the Agreement Randox will develop products for early diagnosis of stroke and subsequent monitoring of treatment outcomes. Financial terms provide Proteome Sciences with seven digit (US dollar) license and development milestones together with double digit royalties on sales.
The clinical discovery and validation of the stroke biomarkers was led by Prof Jean-Charles Sanchez, Director of the University of Geneva Biomedical Proteomics Research Group who commented " The discovery and validation of a panel of early stroke biomarkers in blood opens the way for rapid detection and selection of treatment that will have profound benefits for patients, their families and carers. We have recently studied the potential impact of using just one of these markers, GST-Pi, and found it could increase the number of treated stroke patients five-fold."