RE: OTCQB Application10 May 2023 06:47
Https://longevity.technology/news/sirt6-focused-biotech-cements-longevity-focus-with-heavyweight-appointment/amp/
Longevity.Technology: However, interest in longevity is gaining serious ground – after all, we all have a vested interest in progress in the space. There are economic upsides to improving lifespan and healthspan as well, with a recent paper calculating that a slowdown in aging that increases life expectancy by one year is worth $38 trillion, and for ten years $367 trillion.
SIRTLab Corporation, is one such company that has nailed its longevity colors to the mast; a US Company with research laboratories in the Weizmann Science Park, Israel, SIRTLab has patented a suite of advanced technologies to raise the specific and direct activity of SIRT6 protein to treat various age-related diseases for multiple large markets and existing needs. The company styles itself as “focused on longevity”, and includes liver disease, frailty, metabolic syndrome, neurodegeneration and inflammatory conditions among its targets.
The company was founded by Boaz Misholi and Professor Haim Cohen, a world leader in research of SIRT6, who has seen over $40 million invested in his research.
SIRTLab leads a Longevity Program focused on the high level expression of sirtuin 6 (SIRT6), a key orchestrator of responses to lipids, glucose and inflammation, mainly based on the work of Professor Haim Cohen. Professor Cohen’s lab, along with others, has shown that transgenic overexpression of SIRT6 leads to the restoration of “youthful” energy homeostasis, improved metabolic profiles and significant prolongation of lifespan in mice. A model with overexpression of SIRT6 demonstrated life expansion of up to 50% (with an average of 30% increase) and positive impacts on frailty. In addition, SIRT6 suppresses triglyceride synthesis, fat metabolism and inflammation (by suppression of NF-kB and other pathways), as well as glycolysis. SIRTLab has developed several effective methods to increase the level of SIRT6 within the body cells, and anticipates that clinical trials will start within a year.
Today, SIRTLab has added to its longevity credentials by announcing the appointment Nir Barzilai, MD, as Chief Medical Advisor and a member of the Board of Directors.