Member Info for Moab

JustThinkit

Thank you for this. I was wrong to think CTCs were only to be found when mets had already occurred. There was an RNS some time back mentioning mets occurring in association with clumps of CTCs which I will try to find. Something about CTC clumps also having neutrophils being more likely to metastasise. Obviously CTCs are the source of mets, as apart from local spread there is no other way for mets to occur.

But I agree with your conclusion .

By the way, do you trust ChatGPT in this sort of area? I am completely ignorant.

Thompi

He is hoping to make them complementary by getting onto the tumour DNA bandwagon. I can't blame him. I agree however that both will play an important part in managing malignancy.

The question is: Why does Angle want to analyse circulating tumour DNA in addition to CTCs?. My simple view is that Angle realise that analysing circulating DNA is where the money is. Hence the huge success of Illumina et al.

I cannot see the point of analysing tumour DNA from plasma if one already has CTCs for downstream analysis.

Analysis of tumour DNA and analysing CTCs are at opposite ends of the therapeutic spectrum. The next step after isolation of tumour DNA from plasma is 'now go find the tumour', while the next step after isolating CTCs is downstream analysis of whole DNA allowing more targeted treatment of an existing malignancy.

Why does Angle not seek approval for Parsortix as a primary diagnostic (cancer screening) test?

Because it relies on CTCs which only appear once metastasis is taking place. By contrast, in situ malignant cells break down as a natural process (apoptosis) before any metastasis occurs and the tumour DNA fragments released can be analysed by the likes of Illumina and who can now give a good idea as to the source / site of the malignancy.

Sadly the world has moved on leaving Parsortix (and my investment) in its wake.

Mr Mann is now chairman of a company with major interests in Europe - the EU as we call it. Can we be sure he can go there, including Ireland without being arrested? He has major previous experience in other fields, doubtless he would say sanctioned by the CIA, MI5, etc,. More to the point; Do we know anything about his financial skills? What previous directorships has he held, and would said firms re-appoint him? To repeat myself; quite extraordinary.

From Crazyhorse post: "I was going to be the chief witness in any trial and the CPS guaranteed me immunity from prosecution in this country. But what they could not do was offer the same guarantees about prosecutions elsewhere in Europe. My own lawyers told me it would simply be far too risky for me to go ahead."

It is a truly extraordinary appointment; what is the subtext? I cannot believe for one second that Mann was appointed on his ability to Chair this outfit as a non-exec.

Bert

You are in luck as the Troll Finder General seems to have gone quiet for the present. You raise good points. We also had >£5M in cash at the last Report. But I doubt that PHE would want to raise cash twice, with associated costs. Anyway, their Advisors, who were paid in shares can already bank a profit of ~25% at the present SP.

Fevertreeman

Yes, I think AGL will initially make money - not much - primarily in research, and less, if any, in the clinical field. A huge overhyped, and for me expensive, disappointment at present. Profits are a long way off.

And the price breathtaking... More than £6 a time!

Cureboy

Anybody but S****r, please God. We have had about a month of peace from his rants.

So we will have a 2 tpd of plastic demonstrator is S Wales sometime next year, while the daisies will continue to grow on Protos a while longer. I can see the sense in having something tangible to show the financiers, but remain deeply p1ssed off at the time wasted in the last 3 years. At least we have the certification from June 2021 to say that a full size model might work, altho' that certification was not completed. ("have completed stage one of the validation of the enhanced design to produce 2 tonnes per day of hydrogen.")

Patx

I am confused. The prototype being built at present is a 2 tpd DMG, but is that for 2 tpd of plastic waste or 2 tpd of hydrogen produced? i am assuming the former. but 2 y ago a form of certification for a 2 tpd of hydrogen was given: RNS 29 June 2021. Powerhouse Energy Group plc (AIM: PHE), the UK technology company commercialising hydrogen production from non-recyclable waste plastic, is pleased to announce that DNV, the international gas process design and certification consultancy, have completed stage one of the validation of the enhanced design to produce 2 tonnes per day of hydrogen.

The work was based on the recently completed update of the Front-End Engineering Design (FEED) for Protos which enhanced production options, allowed for variable feedstocks and produced large export packets of hydrogen for use by fleet operators.

So we are going backwards, making a 2 tpd of plastic demonstrator, or is this the 2 tpd of hydrogen full- on DMG for Protos?

Yes, I think we were all lulled into false confidence for 2-3 years when SFA was happening at Protos, encouraged by the reassuring comments of Dr A(pology). I really think we are, at last, going to see a working DMG. Meanwhile some one in Manchester Univ. is working on improvements to gas flow in the thermal chamber, but I hope that does not become a further source of delay, perfection being the enemy of the good etc,.etc,..

Agreed. Keep Keith away from interviews; not his forte.

I like the typo "The patents revolve around their innovative process of converting waste into energy using rotating cameras and steam injection." My Box Brownie could never do that.

Ghengis

Thank you for this. Generally very good presentation, and a glimmer of hope. The newsletter skims carefully over the wasted years when SFA was being done.

Unfortunately KR does not check what he writes - or get someone to do it for him. The last sentence below means (at least to me) that PHE has not spent as much as RT when RT went into administration - with the implication that PHE is headed in the same direction having spent rather less. I am sure he did not mean it, but, not for the first time, he needs an editor!

"Compared to some, PHE has reached a fairly advanced point in the development of its product without spending large sums on equipment, buildings or technical development. Take for example, Recycling Technologies Ltd, to name but one. RT received over £75 million through various grants and deals, but still fell over and went into administration last year. PHE is not very far away in its technical development from where RT was when it went into administration but has spent nothing like that getting there"

Moab

Dr A

Actually, I think you might be doing everyone a favour. We all have had enough of this pointless to and fro.

Patx

But see date of RNS! it is history.

Patx

I thought the 1 tpd DMG has been shown to work satisfactorily, and the plans for a 35tpd DMG were given some sort of accreditation a year or 2 back (June 29 2021). But, as we are told, this is all in the past.

And for the history buffs:

15 October 2013

PowerHouse Energy Group plc (the "Company" or "PowerHouse")

Testing and commissioning program continues

• Longer-term testing showing excellent results

• High quality synthesis gas produced from multiple feed-stocks

• Customer enquiries rising

PowerHouse announces that the testing program begun by its wholly owned subsidiary Pyromex AG ("Pyromex") continues successfully and that the level of customer enquiries to view the operation of the 5 tonne per day unit at Schwartzenbach, Switzerland has risen significantly since testing commenced.

The initial phases of testing, including repeated thermal cycling, long-duration 'dry' operation and the continuous feed of multiple feed-stocks has shown considerable promise for the commercial delivery of the platform on schedule.

As part of the testing programme, Pyromex will be seeking to obtain full EU Compliance Certification for the smaller 5 tonne per day unit which it expects to achieve within the next 30 days.

The testing program and customer demonstrations will continue for the near future with commercial delivery expected in early 2014.

Divvy

i agree with much of what you say, but reiterate that hydrogen was not the only possible output. I think PHE were unwise not to be more flexible in their thinking. I do not know what the cost per Kwh would have been, but electricity production and export to the grid was always an alternative, as was syngas.

The fact that PHE is debt free (at present) is a plus.

moab