Member Info for Miggy007

Trek- I don’t know why you don’t say what you really think :).

'However, in changing the Company's accounting reference date, SYME is technically in breach of the Disclosure Guidance and Transparency Rules (DTR) regarding the timing of these financial statement announcements.'- I don't really follow how this is being spun to be a positive. Ive held these shares in the past and keep an eye on them but it would be good to know if it was a genuine error or purposely non transparent for a reason. Either way I don't see how this will come back and rerate at a higher price?. Based on a c*ck up? Doesn't particularly give me confidence in the management either way. I do like the idea for the business and I'm sure their must be big demand at the moment for the product, but this suspension doesn't shout buy to me. Would love to be proved wrong though and hope current holders make a killing.

Welsh- I’ve got a jigsaw I’ll fashion my own letterbox :)

I think I’d stick a cucumber through 10 Downing Street’s letterbox and shout “the aliens have landed” if this gets FDA approval before the NHS gets to use it. Good for the SP but a **** show from this government.

Hi Trek- their is a Data monitoring committee being used in the Phase III trial so potentially if the drug demonstrated a high efficacy in the trial it could be halted and given emergency use. Not saying it will but it’s a possibility. If the trial replicated a 79% improvement to placebo in the drug arm would that be high enough to satisfy emergency use?.

Woody is just a bit frustrated and eager for news, no big deal really. A decent PA will be the gatekeeper for their boss. Part of their duty really is to syphon out cold callers reaching the boss who are either trying to sell or get him to invest in some product or venture which is of no interest. RM in my experience has been pretty good with Shareholder interaction. He isn’t going to disclose RNS quality info, period. He can’t. Just need patience, we know the Phase III is starting.

Data monitoring committee (DMC):

In the fortunate situation that the experimental arm is shown to be undeniably superior to the control arm the DMC may recommend termination of the trial. This would allow the company sponsoring the trial to get regulatory approval earlier and to allow the superior treatment to get to the patient population earlier. There are cautions here though. The statistical evidence needs to be very high indeed.[citation needed] Also, there might be other reasons to continue, such as collecting more long-term safety data.

-interesting given USA and other regions desperate for a therapeutic that shows high efficacy.

Ghia- I don’t share that concern at all. I think the trial will fill quickly once started given the fact it’s an international trial. Vaccine rollout won’t happen overnight and probably won’t start in serious numbers until the Spring. I suspect part of the reason they instructed Parexel in the first place was their ability to carry out the trial quickly across multiple jurisdictions.

Certain groups cannot take the vaccine, children under 16, pregnant women, certain vulnerable elderly groups. A recent article on the BBC on the issues with vaccination of elderly people stated:

“A vaccine could disrupt transmission, but it is unlikely we will find a vaccine that will completely stop transmission of the virus,” says Sharif. “Influenza vaccines are actually a good example: they do not do much to reduce transmission, but they reduce disease.”

Redbox- funnily enough Epsom Racecourse will be one of the mass vaccination sites. Though I think you are being harsh on SNG. They’ll have done a phase II, home trial and Phase III all within fifteen months. Hardly the performance of a donkey. The Vaccine effort has been phenomenal on a global scale, and let’s be honest we needed it. SNG will still be needed. Don’t see why it wouldn’t be stockpiled against outbreaks of covid and future respiratory viruses.

Just watching ITN News: 23% say they won’t take Vaccine and 10% are not sure. So that’s a third of the population very much against or on the fence. Whether they are right or wrong I don’t know but it shows SNG001 will be needed.

Just my opinion but this seems awfully rushed through. Only seems like a couple of weeks ago it was declared 95% effective. Now in the space of a few weeks we are told it’s perfectly safe to jab us with. But, the Government will keep monitoring to see if any unpleasant side effects occur. In order to give public peace of mind. Seems like the wrong way round to me. Don’t get me wrong I know their is a pressing need, but I’d be happier taking it a year or so down the line just to make sure I don’t start growing another *******.:)

I would imagine result of Synairgens nomination for best tech award would be announced Mon or Tuesday evening. Quite looking forward to it. Fingers crossed.

Gkb- I do have some legal experience and actually studied medical negligence some years ago. Bringing a lawsuit against the government is always a tough ask. Different scenario completely but look at the brick wall the Dunn family have faced trying to get the government to do the right thing. Medical negligence cases per se always had a higher standard of proof threshold. I’m sure if I had lost loved ones to this virus I’d be none to happy the way it’s been handled from up top, with the powers that be carving up vaccines, drugs and testing to line their own pockets with public funds. The tier system is a parlour game to keep us all guessing and keeping our minds off the question of the handling of this pandemic.

Maybe now the government may wish they had supported us a bit more rather than pump all their money and effort into securing a home bred vaccine. Wouldn’t have done them much harm financially to ensure SNG001 was on the shelves for Christmas/January and would have saved thousands of lives in the process. Very disappointing. Bordering criminally negligent.

The full double dose part of the AZN/Oxford trial included over 55’s I believe, which explains the drop in efficacy. Question now is how do we move forward with a vaccine that is only 60% effective. ?

How the hell are AZN spinning this to be a positive???. They mess up a trial, stating that a certain dosing regimen is 90% effective, but omit to tell anyone initially that the cohort for that result was 55 year olds and under. Doesn’t take a genius to work out this won’t be anywhere near 90% effective when you throw in the over 55’s to the new trials that they will be made to undertake. The FDA won’t have this in a million years. They’ve also been lumping in the Brazil part of the trial with the UK data. Trials not carried out under the same conditions. Shambles.

Graking- Admittance to hospital costing several thousand per day you’ll be a drain on the public funds as Joe public. Taking it at home slashes the cost of a hospital stay. And you would be less likely to infect front line medical staff.

I don’t doubt there have been issues with recruitment due to patients not meeting the criteria of early detection of infection. That was always going to be difficult and government failure in testing capacity and availability hasn’t helped either. That’s why SNG were surprised with hospital data from patients who had been infected much longer than four days before receiving treatment. Speed of testing may improve and tests themselves as we proceed but at least for future outbreaks diagnostic companies are not now underfunded or undervalued as scientific entities which they were prior to this outbreak. They were always regarded as big Pharma’s poorer little brother.

That’s not true SNG have been in collaboration with Wessex health trust since earlier this year to advance home trial recruitment. That was before they expanded it nationally and changed the parameters for those infected.