1.
Positive lateral flow, negative PCR
Is the virus mutating again?
https://www.theguardian.com/world/2021/oct/09/negative-pcr-test-covid-symptoms-self-isolate
Cases in local school: staff falling like flies. Several with positive LFTs but negative PCRs. One now in hospital. But head still not allowed to close school! WTF!
2. Flu + Covid risks
https://www.theguardian.com/world/2021/oct/10/getting-flu-with-covid-makes-you-twice-as-likely-to-die-says-uk-health-chief
I think the clue was at the beginning of the interim video report.
Near the start, RM states:
“we are progressing well with the US govt who have included us in the Activ2 trial"
before following this with usual caveats.
The Interim Report video is now available on the Synairgen website - but not the Q&A
In light of today's events, this is probably not particularly timely but nevertheless, I found it interesting to watch RM's video as I had not been able to watch it live.
Picked up a few things not least RM saying near the beginning that "we are progressing well with the US govt who have included us in the Activ2 trial" before following this with caveats.
Found it. It was right in front of my eyes!
"Unblinded Day 28 data will also be provided to a small group of people from the company who owns the investigational agent, to assist the company in deciding if the agent should move into phase 3 evaluation; or in choosing a dose of their agent to move into phase 3 evaluation."
Source:
https://clinicaltrials.gov/ct2/show/NCT04518410?term=ACTIV-2&draw=2
Just scrolled through today's comments on this thread. Apologies if this has already been mentioned.
On the Activ2, it does mention that certain key personnel in the supplying company will be updated with the results. (Sorry, cannot lay my hands on this actual quote atm though I did post it previously.)
Taken at face value, and with RM not overtly showing confidence that SNG001 will progress to A2P3, that would imply either or both:
a) he has been cautioned against preempting the NIH decision either way
b) the initial A2P2 results may have reflected our own home trial results and be inconclusive so the NIH is still deciding whether to pursue A2P3 or wait for results from Sprinter.
So very sad
Happened in Portsmouth - what a waste of a young life when SNG could have saved her
https://www.bbc.co.uk/news/uk-england-hampshire-58772671
Does this actually make sound financial sense?
$700 for mild to moderate cases, halving risk of hospitalisation to 7.5%. Isn't this still rather expensive? Even for USA? How much will the US health insurance companies payout for mild-moderate case, when most (85% by Merck's estimate) do not need hospitalisation. Yes, I know the US govt has made some sort of pre-order, but even so, how are they going to decide who gets Merck's pill? If just the moderate cases, what % of these will still end up in hospital as compared to the 7.5% when numbers are diluted with a combination of mild and moderate cases. I say clever PR machine.
Hmm. I'm panicking less now.
You might be on to something there, alkin. I noted this:
People living in the same household with someone who has tested positive for Covid-19, at least one related symptom and has not had signs or symptoms for more than five days will be eligible for the trial.
So have they included people who might not actually have had Covid?
Can I have more than one ‘pin’?!
Based on a previous price projection (assuming positive SP tomorrow):
First barrier to clear, an ascending channel; limited by a ,hopefully temporary, barrier at last high of 258.
Then 325.
A quick search on the BMJ brought up some old articles with seemingly negative bias towards interferon - I don't have membership so cannot confirm the detail. It did get me wondering how steep a hill Synairgen has had to climb to provide data, not only reverse the negative WHO trial, but also decades of antipathy towards interferon.
It gives even more weighting to the BoD's comments that 'data is king.'
I echo Saxondale, we need the results for SNG to get into the limelight. And a lot of work must be happening to prepare the ground to receive the data.
Just had a chance to review the video
FWIW:
Dr Wohl did not appear to single out any one of the remaining 3 treatments. If anything, he repeated a phrase I’ve heard Fauci used earlier in the year re: looking for a pill much like Tamiflu... a game changer.
Doesn’t mean we won’t have good news on 30/9 but I don’t think we can safely take more away from this video beyond that we are still on Activ2.
With regards the appearance of speaking off camera to someone else, that is unlikely. True, Dr W looks left and right when speaking but as this is a recorded Zoom call, there are no cameramen and he clearly is just sitting at a desk in a room.
Believe me, I really want the news on Thursday to be good, great even, but we must be careful about confirmation bias.
I had trouble finding it on my pc too but no problem on my mobile!
See if this link works better:
https://us.riseabovecovid.org/us/en/