RE: Sunday Roast26 Apr 2026 20:39
Sunday Roast- starts at 47.44
001 - must be retained in house as out licensing was not mentioned at all?
002 - working thru bridging data, part 1 received, they are looking at what they have - in phase 2b by year end 2026 which ties in with prev rns, part 2 of data would be received in H2.
014 - Mdma improves ptsd but has risk of triggering heart attacks as it metabolises into mda.
Prof Nutt has chemically engineered out the change into mda ( they think) and reduced the dosage and effects of mdma, this reduces abuse risk and gives it a brand new I.P. identity ( patented).
They are looking to produce this as a tablet ' soft drug that washes through" this means being more efficient in the health care setting, (prev suggested, home use for a daily tablet?), it looks like mdma but on a very lower level, we are very pleased as best we can be at this stage", next up we are 014 - looking at funding in uk, eu and usa as we have small businesses in each of these territories.
Composition of matter patents on 014 are the " Gold Standard.
"That's where we are with that and we are pleased".
Other patents pending.
Phil -looking at bigger picture, taking a step back, how should investors think about key milestones from here?
A.T. - getting funding from one of those 3 territories I mentioned, then progress to an ind enabling studies - note he said studies plural and not study! I.e. can 014 be split like 015 has been?
Potential value basis, look at Transcend deal to Otsuka, yes further on but known drug, limited patent not a gold standard.( paid $700m plus $525m future milestones).
Kevin:Joe Rogan, Ibogain and research
A.T. lot of this research has been done already.
Ibogaine: it's got poor health side effects - known cardio risk - ( note what Nutt did with reengineering MDMA.)
Lot of data in next 12 - 24 months from peer companies in phase 2 and 3 - (hinting at M & A interest?) All of which to us is positive as we are going to be a fast follower in this market... from a capital markets basis looking much more attractive ( easier to list on nasdaq than it was 2022-25 )
Rfk jnr - Important to these changes.
Sea change in u.s, fda & federal focus on change in tempo.
Mar a Lago in DECEMBER, other ppl adjacent to Trump saying, lets get business done.
Peer co's to us, market caps €250 - 2bn, very large and future market for us, Chairman knows that mkt pretty well.
001 - targeting 8 to 10 years licensing at some point in the future - being retained and run into production.
002 U.s. I.p. needs better protection than we can get in uk for 001.
We identified 002 - lts lohmann in licensed at zero cost, got a method of use patent in the us target the us orange book you get up to 5.5 years protection (i.e. long enough to build your business and tie up the clinics from competitors.)
And thats what we are doing.
We are working to establish the bridge with wuxi across two works packages, working on second part of