Member Info for Lionel1

Https://buckup-cuh-production.s3.amazonaws.com/documents/CYP2C19_genotype_testing_-_Implementation_Guidance_Jan_2025_v1.pdf

I am not sure why they recruiting more people when they are running out of cash , any financial institution backing ??

Lol welcome to the club Emerald:-) .

@winnimandala , well said , I think GDR working on multigene Pharmacogenomic test , we should hear soon .

Further to this , Cyp2c19 POc trial started in primary care settings and community pharmacies until end of 2025 .

Https://www.nes.scot.nhs.uk/media/4ixpfpvw/7-matthew-beaney-the-rise-of-clinical-pharmacogenomics.pdf

The future of pharmacogenomics

The NHS Tayside P4Me - CYP2C19/ clopidogrel innovation is undergoing approval for rollout to other Scottish healthboards through the ANIA programme. This testing is seen as a pathfinder to broader PGx testing in NHS Scotland.

Proposed PGx testing also includes point of care (POC) testing in NHS Scotland hospital wards (e.g. a neotnatal POC test to identify and remove the risk of permanent hearing loss for babies from gentamicin (antibiotic) induced ototoxicity.)

In the future we will move away from single gene testing to a more cost effective and informative multi-gene panel approach.

Https://news.liverpool.ac.uk/2025/01/28/new-pharmacogenomics-centre-to-help-uk-move-towards-personalised-prescribing/amp/

Https://www.nw-gmsa.nhs.uk/media-news-and-events/latest-news-blogs/national-rollout-phase-ii-progress-pharmacogenomics-research-study

https://www.dbth.nhs.uk/news/doncaster-and-bassetlaw-teaching-hospitals-chosen-for-trailblazing-national-genetic-testing-pilot

The test valley children hospital trialing out is atleast 5 years away from commercialisation. :-)

@Jimi , don’t waste your time explaining anything to this Fuc*rs , they know everything but they pretend like …

We can wake up someone who is really sleeping, but we can’t wake up someone who is pretending to be sleeping ..

These 2 psychopaths still here ?? Slacker and stocksaint why don’t you better use yourself somewhere else .. possibly in the bin

Here are key signs that may indicate someone is a psychopath:

• Lack of Empathy: Psychopaths are unable to empathize with others, showing no concern for others’ emotions or suffering.

• Superficial Charm: They often appear charismatic and charming but use this to manipulate others for personal gain.

• Impulsivity: Psychopaths tend to act without considering consequences, seeking thrill and excitement.

• Callousness and Cruelty: They may display unnecessary cruelty, enjoy humiliating others, or show a mean streak once their charm fades.

• Lack of Remorse or Accountability: Psychopaths rarely feel guilt for their actions and often blame others instead of taking responsibility.

• Cold and Detached Demeanor: They may seem emotionally distant or indifferent in situations where emotions are expected.

• Manipulative Behavior: Psychopaths frequently lie, deceive, or exploit others to achieve their goals.

Can we all report this id** and get him banned one more time , I am sure he will reappear with another handle like jealous lover .. shameless

“Answer not a fool according to his folly, lest you be like him yourself. Answer a fool according to his folly, lest he be wise in his own eyes.”

Goodluck .

whilst scheduled for a maximum of 18 months, performance data can be submitted to the nice eva evidence

generation team at an earlier point if the team believes the evidence generation requirements have been

successfully fulfilled. performance data generated during the programme is also expected to contribute towards

clinical performance data requirements for fda as part of planned de novo submission process required for

commercial entry into the u.s.

https://www.genedriveplc.com/press-releases/gdr_-_nihr_(21.11.24).pdf

apologies accepted, you are mentally ****** and not fit for discussion .

@starres, don’t you see the difference between “24 months study” and “18 months evidence collection” .

Coming to your post this morning , I mostly agree with you .. LTH come back in 2027 to collect your fruits .

@Gloria , that’s called selective reading ..

PALOH-UK study length is 24 months and evidence collection period is up to 18 months , these are 2 different things as far as I know .

“The PALOH-UK study will demonstrate how the test can be used in a timely way to ensure babies get a safe, effective antibiotic without affecting normal clinical practice, on a much larger scale.”

Https://www.nw-gmsa.nhs.uk/media-news-and-events/latest-news-blogs/advancing-application-pharmacogenomics-digital-innovation-introducing-progressrx-1

@stock ,

NICE diagnostic guidance recommends using CYP2C19 genotype testing to determine whether clopidogrel is the most suitable antiplatelet for people who have had an ischaemic stroke or TIA.

3. The results of a NICE economic model show that point of care and laboratory-based genotype testing were more effective and less costly than no testing. Both types of test generated similar cost savings and quality adjusted life years (QALYs).

4. Our cost analysis for NHSScotland found that genotype-guided antiplatelet therapy was resource saving compared with no testing, resulting from a reduction in-hospital and rehabilitation costs associated with fewer people having a recurrent stroke

Laboratory-based genotype-guided antiplatelet therapy was resource saving from the year of implementation. Over a 5-year period, resource savings amounted to €17.9 million, based on 943 fewer people having a recurrent stroke.

Point of care genotype testing was cost incurring in the year of implementation and from year two onwards became resource saving. Over a 5-year period, the Genedrive point of care test was associated with £18 million in resource savings and 961 fewer recurrent strokes. Over the same period, the Genomadix Cube point of care test was associated with resource savings of £17.6 million, based on 958 fewer people having a recurrent stroke.

https://shtg.scot/media/2497/20241030-clopidogrel-assessment-v10.pdf

I think going forward PGx will be rolled out to community pharmacies for preemptive testing in NHS , other countries in Europe already doing , GDR might get a piece of cake , I know GdR is well placed for emergency settings .

https://youtu.be/vBEFdNpJd_w?si=jVUKxSbI_RBz0ZUN

Hold on for an hour , Slacker and stocksaint will be here any moment for their night shift , they will come up with nice cooked story … :-)